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This page was generated on 2025-03-27 11:45 -0400 (Thu, 27 Mar 2025).

HostnameOSArch (*)R versionInstalled pkgs
nebbiolo1Linux (Ubuntu 24.04.1 LTS)x86_64R Under development (unstable) (2025-03-13 r87965) -- "Unsuffered Consequences" 4783
palomino7Windows Server 2022 Datacenterx64R Under development (unstable) (2025-03-01 r87860 ucrt) -- "Unsuffered Consequences" 4552
lconwaymacOS 12.7.1 Montereyx86_64R Under development (unstable) (2025-03-02 r87868) -- "Unsuffered Consequences" 4581
kjohnson3macOS 13.7.1 Venturaarm64R Under development (unstable) (2025-03-02 r87868) -- "Unsuffered Consequences" 4533
kunpeng2Linux (openEuler 24.03 LTS)aarch64R Under development (unstable) (2025-02-19 r87757) -- "Unsuffered Consequences" 4463
Click on any hostname to see more info about the system (e.g. compilers)      (*) as reported by 'uname -p', except on Windows and Mac OS X

Package 526/2315HostnameOS / ArchINSTALLBUILDCHECKBUILD BIN
decoupleR 2.13.0  (landing page)
Pau Badia-i-Mompel
Snapshot Date: 2025-03-26 13:40 -0400 (Wed, 26 Mar 2025)
git_url: https://git.bioconductor.org/packages/decoupleR
git_branch: devel
git_last_commit: 1d86763
git_last_commit_date: 2024-10-29 11:00:29 -0400 (Tue, 29 Oct 2024)
nebbiolo1Linux (Ubuntu 24.04.1 LTS) / x86_64  OK    OK    WARNINGS  UNNEEDED, same version is already published
palomino7Windows Server 2022 Datacenter / x64  OK    OK    WARNINGS    OK  UNNEEDED, same version is already published
lconwaymacOS 12.7.1 Monterey / x86_64  OK    OK    WARNINGS    OK  UNNEEDED, same version is already published
kjohnson3macOS 13.7.1 Ventura / arm64  OK    OK    ERROR    OK  
kunpeng2Linux (openEuler 24.03 LTS) / aarch64  OK    OK    ERROR  


CHECK results for decoupleR on kjohnson3

To the developers/maintainers of the decoupleR package:
- Allow up to 24 hours (and sometimes 48 hours) for your latest push to git@git.bioconductor.org:packages/decoupleR.git to reflect on this report. See Troubleshooting Build Report for more information.
- Use the following Renviron settings to reproduce errors and warnings.
- If 'R CMD check' started to fail recently on the Linux builder(s) over a missing dependency, add the missing dependency to 'Suggests:' in your DESCRIPTION file. See Renviron.bioc for more information.

raw results


Summary

Package: decoupleR
Version: 2.13.0
Command: /Library/Frameworks/R.framework/Resources/bin/R CMD check --install=check:decoupleR.install-out.txt --library=/Library/Frameworks/R.framework/Resources/library --no-vignettes --timings decoupleR_2.13.0.tar.gz
StartedAt: 2025-03-26 18:56:32 -0400 (Wed, 26 Mar 2025)
EndedAt: 2025-03-26 19:03:09 -0400 (Wed, 26 Mar 2025)
EllapsedTime: 396.7 seconds
RetCode: 1
Status:   ERROR  
CheckDir: decoupleR.Rcheck
Warnings: NA

Command output

##############################################################################
##############################################################################
###
### Running command:
###
###   /Library/Frameworks/R.framework/Resources/bin/R CMD check --install=check:decoupleR.install-out.txt --library=/Library/Frameworks/R.framework/Resources/library --no-vignettes --timings decoupleR_2.13.0.tar.gz
###
##############################################################################
##############################################################################


* using log directory ‘/Users/biocbuild/bbs-3.21-bioc/meat/decoupleR.Rcheck’
* using R Under development (unstable) (2025-03-02 r87868)
* using platform: aarch64-apple-darwin20
* R was compiled by
    Apple clang version 14.0.0 (clang-1400.0.29.202)
    GNU Fortran (GCC) 14.2.0
* running under: macOS Ventura 13.7.1
* using session charset: UTF-8
* using option ‘--no-vignettes’
* checking for file ‘decoupleR/DESCRIPTION’ ... OK
* checking extension type ... Package
* this is package ‘decoupleR’ version ‘2.13.0’
* package encoding: UTF-8
* checking package namespace information ... OK
* checking package dependencies ... OK
* checking if this is a source package ... OK
* checking if there is a namespace ... OK
* checking for hidden files and directories ... OK
* checking for portable file names ... OK
* checking for sufficient/correct file permissions ... OK
* checking whether package ‘decoupleR’ can be installed ... OK
* checking installed package size ... OK
* checking package directory ... OK
* checking ‘build’ directory ... OK
* checking DESCRIPTION meta-information ... OK
* checking top-level files ... OK
* checking for left-over files ... OK
* checking index information ... OK
* checking package subdirectories ... OK
* checking code files for non-ASCII characters ... OK
* checking R files for syntax errors ... OK
* checking whether the package can be loaded ... OK
* checking whether the package can be loaded with stated dependencies ... OK
* checking whether the package can be unloaded cleanly ... OK
* checking whether the namespace can be loaded with stated dependencies ... OK
* checking whether the namespace can be unloaded cleanly ... OK
* checking dependencies in R code ... NOTE
[2025-03-26 18:56:46] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-03-26 18:56:46] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-03-26 18:56:46] [INFO]    [OmnipathR] Initialized cache: `/Users/biocbuild/Library/Caches/OmnipathR`.
[2025-03-26 18:56:46] [INFO]    [OmnipathR] Package `OmnipathR` packaged: NA
[2025-03-26 18:56:46] [INFO]    [OmnipathR] Package `OmnipathR` date/publication: 2025-03-26
[2025-03-26 18:56:46] [INFO]    [OmnipathR] Package `OmnipathR` built: R 4.5.0; ; 2025-03-26 19:05:27 UTC; unix
[2025-03-26 18:56:46] [INFO]    [OmnipathR] Package `OmnipathR` version: 3.15.11
[2025-03-26 18:56:46] [INFO]    [OmnipathR] Package `OmnipathR` repository: Bioconductor 3.21
[2025-03-26 18:56:47] [INFO]    [OmnipathR] Session info: [version=R Under development (unstable) (2025-03-02 r87868); os=macOS Ventura 13.7.1; system=aarch64, darwin20; ui=X11; language=(EN); collate=C; ctype=en_US.UTF-8; tz=America/New_York; date=2025-03-26; pandoc=3.1.12.3 @ /opt/homebrew/bin/ (via rmarkdown); quarto=1.4.552 @ /usr/local/bin/quarto]
[2025-03-26 18:56:47] [INFO]    [OmnipathR] External libraries: [cairo=1.17.6; cairoFT=; pango=1.50.14; png=1.6.44; jpeg=9.5; tiff=LIBTIFF, Version 4.5.0; tcl=8.6.13; curl=8.7.1; zlib=1.2.11; bzlib=1.0.8, 13-Jul-2019; xz=5.6.3; deflate=1.23; PCRE=10.44 2024-06-07; ICU=70.2; TRE=TRE 0.8.0 R_fixes (BSD); iconv=Apple or GNU libiconv 1.11 /Library/Frameworks/R.framework/Versions/4.5-arm64/Resources/lib/libR.dylib; readline=5.2; BLAS=/Library/Frameworks/R.framework/Versions/4.5-arm64/Resources/lib/libRblas.0.dylib; lapack=/Library/Frameworks/R.framework/Versions/4.5-arm64/Resources/lib/libRlapack.dylib; lapack_version=3.12.0]
[2025-03-26 18:56:47] [INFO]    [OmnipathR] Loaded packages: abind 1.4-8(2024-09-12); annotate 1.85.0(2025-03-26); AnnotationDbi 1.69.0(2025-03-26); AUCell 1.29.0(2025-03-26); backports 1.5.0(2024-05-23); beachmat 2.23.7(2025-03-26); Biobase 2.67.0(2025-03-26); BiocGenerics 0.53.6(2025-03-26); BiocParallel 1.41.2(2025-03-26); BiocSingular 1.23.0(2025-03-26); Biostrings 2.75.4(2025-03-26); bit 4.6.0(2025-03-06); bit64 4.6.0-1(2025-01-16); blob 1.2.4(2023-03-17); cachem 1.1.0(2024-05-16); cellranger 1.1.0(2016-07-27); checkmate 2.3.2(2024-07-29); chromote 0.5.0(2025-03-21); cli 3.6.4(2025-02-13); codetools 0.2-20(2024-03-31); crayon 1.5.3(2024-06-20); curl 6.2.2(2025-03-24); data.table 1.17.0(2025-02-22); DBI 1.2.3(2024-06-02); decoupleR 2.13.0(2025-03-26); DelayedArray 0.33.6(2025-03-26); DelayedMatrixStats 1.29.1(2025-03-26); digest 0.6.37(2024-08-19); dplyr 1.1.4(2023-11-17); evaluate 1.0.3(2025-01-10); fastmap 1.2.0(2024-05-15); fs 1.6.5(2024-10-30); generics 0.1.3(2022-07-05); GenomeInfoDb 1.43.4(2025-03-26); GenomeInfoDbData 1.2.14(2025-03-12); GenomicRanges 1.59.1(2025-03-26); glue 1.8.0(2024-09-30); graph 1.85.3(2025-03-26); GSEABase 1.69.1(2025-03-26); GSVA 2.1.10(2025-03-26); h5mread 0.99.4(2025-03-26); HDF5Array 1.35.16(2025-03-26); hms 1.1.3(2023-03-21); htmltools 0.5.8.1(2024-04-04); httr 1.4.7(2023-08-15); httr2 1.1.2(2025-03-26); igraph 2.1.4(2025-01-23); IRanges 2.41.3(2025-03-26); irlba 2.3.5.1(2022-10-03); jsonlite 1.9.1(2025-03-03); KEGGREST 1.47.0(2025-03-26); knitr 1.50(2025-03-16); later 1.4.1(2024-11-27); lattice 0.22-6(2024-03-20); lifecycle 1.0.4(2023-11-07); logger 0.4.0(2024-10-22); lubridate 1.9.4(2024-12-08); magick 2.8.6(2025-03-23); magrittr 2.0.3(2022-03-30); Matrix 1.7-3(2025-03-11); MatrixGenerics 1.19.1(2025-03-26); matrixStats 1.5.0(2025-01-07); memoise 2.0.1(2021-11-26); OmnipathR 3.15.11(2025-03-26); parallelly 1.43.0(2025-03-24); pillar 1.10.1(2025-01-07); pkgconfig 2.0.3(2019-09-22); png 0.1-8(2022-11-29); prettyunits 1.2.0(2023-09-24); processx 3.8.6(2025-02-21); progress 1.2.3(2023-12-06); promises 1.3.2(2024-11-28); ps 1.9.0(2025-02-18); purrr 1.0.4(2025-02-05); R.methodsS3 1.8.2(2022-06-13); R.oo 1.27.0(2024-11-01); R.utils 2.13.0(2025-02-24); R6 2.6.1(2025-02-15); rappdirs 0.3.3(2021-01-31); Rcpp 1.0.14(2025-01-12); readr 2.1.5(2024-01-10); readxl 1.4.5(2025-03-07); rhdf5 2.51.2(2025-03-26); rhdf5filters 1.19.2(2025-03-26); Rhdf5lib 1.29.2(2025-03-26); rjson 0.2.23(2024-09-16); rlang 1.1.5(2025-01-17); rmarkdown 2.29(2024-11-04); RSQLite 2.3.9(2024-12-03); rsvd 1.0.5(2021-04-16); rvest 1.0.4(2024-02-12); S4Arrays 1.7.3(2025-03-26); S4Vectors 0.45.4(2025-03-26); ScaledMatrix 1.15.0(2025-03-26); sessioninfo 1.2.3(2025-02-05); SingleCellExperiment 1.29.2(2025-03-26); SparseArray 1.7.7(2025-03-26); sparseMatrixStats 1.19.0(2025-03-26); SpatialExperiment 1.17.0(2025-03-26); stringi 1.8.4(2024-05-06); stringr 1.5.1(2023-11-14); SummarizedExperiment 1.37.0(2025-03-26); tibble 3.2.1(2023-03-20); tidyr 1.3.1(2024-01-24); tidyselect 1.2.1(2024-03-11); timechange 0.3.0(2024-01-18); tzdb 0.5.0(2025-03-15); UCSC.utils 1.3.1(2025-03-26); vctrs 0.6.5(2023-12-01); websocket 1.4.2(2024-07-22); withr 3.0.2(2024-10-28); xfun 0.51(2025-02-19); XML 3.99-0.18(2025-01-01); xml2 1.3.8(2025-03-14); xtable 1.8-4(2019-04-21); XVector 0.47.2(2025-03-26); yaml 2.3.10(2024-07-26); zip 2.3.2(2025-02-01)
[2025-03-26 18:56:47] [INFO]    [OmnipathR] CURL: version: 8.11.1; headers: 8.11.1; ssl_version: OpenSSL/3.3.2 (SecureTransport); libz_version: 1.2.11; libssh_version: NA; libidn_version: NA; host: aarch64-apple-darwin23.6.0; protocols: dict, file, ftp, ftps, gopher, gophers, http, https, imap, imaps, ldap, ldaps, mqtt, pop3, pop3s, rtsp, smb, smbs, smtp, smtps, telnet, tftp, ws, wss; ipv6: TRUE; http2: TRUE; idn: FALSE; url_parser: TRUE
[2025-03-26 18:56:47] [TRACE]   [OmnipathR] Running on a build server, wiping cache.
[2025-03-26 18:56:47] [TRACE]   [OmnipathR] Cache is at `/Users/biocbuild/Library/Caches/OmnipathR`.
[2025-03-26 18:56:47] [TRACE]   [OmnipathR] Contains 8 files.
[2025-03-26 18:56:47] [TRACE]   [OmnipathR] Cache is locked: FALSE.
[2025-03-26 18:56:47] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-03-26 18:56:47] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-03-26 18:56:47] [SUCCESS] [OmnipathR] Removing all cache contents from `/Users/biocbuild/Library/Caches/OmnipathR`.
[2025-03-26 18:56:47] [TRACE]   [OmnipathR] Pandoc version: `3.1.12.3`.
[2025-03-26 18:56:47] [TRACE]   [OmnipathR] Reading JSON from `/Library/Frameworks/R.framework/Versions/4.5-arm64/Resources/library/OmnipathR/db/db_def.json` (encoding: UTF-8).
[2025-03-26 18:56:47] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-03-26 18:56:47] [TRACE]   [OmnipathR] Reading JSON from `/Library/Frameworks/R.framework/Versions/4.5-arm64/Resources/library/OmnipathR/internal/magic_bytes.json` (encoding: UTF-8).
[2025-03-26 18:56:47] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-03-26 18:56:47] [TRACE]   [OmnipathR] Reading JSON from `/Library/Frameworks/R.framework/Versions/4.5-arm64/Resources/library/OmnipathR/internal/urls.json` (encoding: UTF-8).
[2025-03-26 18:56:47] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-03-26 18:56:47] [TRACE]   [OmnipathR] Reading JSON from `/Library/Frameworks/R.framework/Versions/4.5-arm64/Resources/library/OmnipathR/internal/id_types.json` (encoding: UTF-8).
[2025-03-26 18:56:47] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-03-26 18:56:47] [TRACE]   [OmnipathR] Cache locked: FALSE
* checking S3 generic/method consistency ... OK
* checking replacement functions ... OK
* checking foreign function calls ... OK
* checking R code for possible problems ... OK
* checking Rd files ... OK
* checking Rd metadata ... OK
* checking Rd cross-references ... WARNING
Missing link(s) in Rd file 'run_gsva.Rd':
  ‘GSVA::gsva’ ‘GeneSetCollection’

See section 'Cross-references' in the 'Writing R Extensions' manual.

Found the following Rd file(s) with Rd \link{} targets missing package
anchors:
  run_gsva.Rd: GSVA::gsva, GeneSetCollection
Please provide package anchors for all Rd \link{} targets not in the
package itself and the base packages.
* checking for missing documentation entries ... OK
* checking for code/documentation mismatches ... OK
* checking Rd \usage sections ... OK
* checking Rd contents ... OK
* checking for unstated dependencies in examples ... OK
* checking files in ‘vignettes’ ... OK
* checking examples ... OK
Examples with CPU (user + system) or elapsed time > 5s
                user system elapsed
run_fgsea     10.171  0.710  12.681
get_dorothea   7.603  0.633  12.960
run_aucell     3.798  1.714   8.669
get_collectri  3.149  0.394  10.792
get_progeny    2.874  0.235  10.403
* checking for unstated dependencies in ‘tests’ ... OK
* checking tests ...
  Running ‘testthat.R’
 ERROR
Running the tests in ‘tests/testthat.R’ failed.
Last 13 lines of output:
  [120] 0.112          | 0.112            [120]
  [121] 0.991          - 1.000            [121]
  [122] 0.991          - 1.000            [122]
  [123] 0.123          - 0.126            [123]
  [124] 0.123          - 0.126            [124]
  [125] 0.156          | 0.156            [125]
  [126] 0.156          | 0.156            [126]
  [127] 0.592          | 0.592            [127]
  
    `actual$p_value[132:139]`: 0.125 0.592 0.592 0.175 0.175 0.198 0.198 0.592
  `expected$p_value[132:139]`: 0.125 0.592 0.592 0.184 0.184 0.198 0.198 0.592
  
  [ FAIL 1 | WARN 9 | SKIP 0 | PASS 34 ]
  Error: Test failures
  Execution halted
* checking for unstated dependencies in vignettes ... OK
* checking package vignettes ... OK
* checking running R code from vignettes ... SKIPPED
* checking re-building of vignette outputs ... SKIPPED
* checking PDF version of manual ... OK
* DONE

Status: 1 ERROR, 1 WARNING, 1 NOTE
See
  ‘/Users/biocbuild/bbs-3.21-bioc/meat/decoupleR.Rcheck/00check.log’
for details.


Installation output

decoupleR.Rcheck/00install.out

##############################################################################
##############################################################################
###
### Running command:
###
###   /Library/Frameworks/R.framework/Resources/bin/R CMD INSTALL decoupleR
###
##############################################################################
##############################################################################


* installing to library ‘/Library/Frameworks/R.framework/Versions/4.5-arm64/Resources/library’
* installing *source* package ‘decoupleR’ ...
** this is package ‘decoupleR’ version ‘2.13.0’
** using staged installation
** R
** inst
** byte-compile and prepare package for lazy loading
** help
*** installing help indices
*** copying figures
** building package indices
** installing vignettes
** testing if installed package can be loaded from temporary location
** testing if installed package can be loaded from final location
** testing if installed package keeps a record of temporary installation path
* DONE (decoupleR)

Tests output

decoupleR.Rcheck/tests/testthat.Rout.fail


R Under development (unstable) (2025-03-02 r87868) -- "Unsuffered Consequences"
Copyright (C) 2025 The R Foundation for Statistical Computing
Platform: aarch64-apple-darwin20

R is free software and comes with ABSOLUTELY NO WARRANTY.
You are welcome to redistribute it under certain conditions.
Type 'license()' or 'licence()' for distribution details.

R is a collaborative project with many contributors.
Type 'contributors()' for more information and
'citation()' on how to cite R or R packages in publications.

Type 'demo()' for some demos, 'help()' for on-line help, or
'help.start()' for an HTML browser interface to help.
Type 'q()' to quit R.

> library(testthat)
> library(decoupleR)
> 
> test_check("decoupleR")

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[2025-03-26 18:58:28] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-03-26 18:58:28] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-03-26 18:58:28] [INFO]    [OmnipathR] Initialized cache: `/Users/biocbuild/Library/Caches/OmnipathR`.
[2025-03-26 18:58:28] [INFO]    [OmnipathR] Package `OmnipathR` packaged: NA
[2025-03-26 18:58:28] [INFO]    [OmnipathR] Package `OmnipathR` date/publication: 2025-03-26
[2025-03-26 18:58:28] [INFO]    [OmnipathR] Package `OmnipathR` built: R 4.5.0; ; 2025-03-26 19:05:27 UTC; unix
[2025-03-26 18:58:28] [INFO]    [OmnipathR] Package `OmnipathR` version: 3.15.11
[2025-03-26 18:58:28] [INFO]    [OmnipathR] Package `OmnipathR` repository: Bioconductor 3.21
[2025-03-26 18:58:28] [INFO]    [OmnipathR] Session info: [version=R Under development (unstable) (2025-03-02 r87868); os=macOS Ventura 13.7.1; system=aarch64, darwin20; ui=X11; language=C; collate=C; ctype=en_US.UTF-8; tz=America/New_York; date=2025-03-26; pandoc=3.1.12.3 @ /opt/homebrew/bin/ (via rmarkdown); quarto=1.4.552 @ /usr/local/bin/quarto]
[2025-03-26 18:58:28] [INFO]    [OmnipathR] External libraries: [cairo=1.17.6; cairoFT=; pango=1.50.14; png=1.6.44; jpeg=9.5; tiff=LIBTIFF, Version 4.5.0; tcl=8.6.13; curl=8.7.1; zlib=1.2.11; bzlib=1.0.8, 13-Jul-2019; xz=5.6.3; deflate=1.23; PCRE=10.44 2024-06-07; ICU=70.2; TRE=TRE 0.8.0 R_fixes (BSD); iconv=Apple or GNU libiconv 1.11 /Library/Frameworks/R.framework/Versions/4.5-arm64/Resources/lib/libR.dylib; readline=5.2; BLAS=/Library/Frameworks/R.framework/Versions/4.5-arm64/Resources/lib/libRblas.0.dylib; lapack=/Library/Frameworks/R.framework/Versions/4.5-arm64/Resources/lib/libRlapack.dylib; lapack_version=3.12.0]
[2025-03-26 18:58:29] [INFO]    [OmnipathR] Loaded packages: abind 1.4-8(2024-09-12); annotate 1.85.0(2025-03-26); AnnotationDbi 1.69.0(2025-03-26); AUCell 1.29.0(2025-03-26); backports 1.5.0(2024-05-23); beachmat 2.23.7(2025-03-26); Biobase 2.67.0(2025-03-26); BiocGenerics 0.53.6(2025-03-26); BiocParallel 1.41.2(2025-03-26); BiocSingular 1.23.0(2025-03-26); Biostrings 2.75.4(2025-03-26); bit 4.6.0(2025-03-06); bit64 4.6.0-1(2025-01-16); blob 1.2.4(2023-03-17); brio 1.1.5(2024-04-24); broom 1.0.7(2024-09-26); cachem 1.1.0(2024-05-16); cellranger 1.1.0(2016-07-27); checkmate 2.3.2(2024-07-29); chromote 0.5.0(2025-03-21); class 7.3-23(2025-01-01); cli 3.6.4(2025-02-13); codetools 0.2-20(2024-03-31); colorspace 2.1-1(2024-07-26); cowplot 1.1.3(2024-01-22); crayon 1.5.3(2024-06-20); curl 6.2.2(2025-03-24); data.table 1.17.0(2025-02-22); DBI 1.2.3(2024-06-02); decoupleR 2.13.0(2025-03-26); DelayedArray 0.33.6(2025-03-26); DelayedMatrixStats 1.29.1(2025-03-26); desc 1.4.3(2023-12-10); digest 0.6.37(2024-08-19); dplyr 1.1.4(2023-11-17); e1071 1.7-16(2024-09-16); evaluate 1.0.3(2025-01-10); fastmap 1.2.0(2024-05-15); fastmatch 1.1-6(2024-12-23); fgsea 1.33.4(2025-03-26); fs 1.6.5(2024-10-30); generics 0.1.3(2022-07-05); GenomeInfoDb 1.43.4(2025-03-26); GenomeInfoDbData 1.2.14(2025-03-12); GenomicRanges 1.59.1(2025-03-26); ggplot2 3.5.1(2024-04-23); glue 1.8.0(2024-09-30); graph 1.85.3(2025-03-26); GSEABase 1.69.1(2025-03-26); GSVA 2.1.10(2025-03-26); gtable 0.3.6(2024-10-25); h5mread 0.99.4(2025-03-26); HDF5Array 1.35.16(2025-03-26); hms 1.1.3(2023-03-21); htmltools 0.5.8.1(2024-04-04); htmlwidgets 1.6.4(2023-12-06); httr 1.4.7(2023-08-15); httr2 1.1.2(2025-03-26); igraph 2.1.4(2025-01-23); IRanges 2.41.3(2025-03-26); irlba 2.3.5.1(2022-10-03); jsonlite 1.9.1(2025-03-03); KEGGREST 1.47.0(2025-03-26); kernlab 0.9-33(2024-08-13); KernSmooth 2.23-26(2025-01-01); knitr 1.50(2025-03-16); later 1.4.1(2024-11-27); lattice 0.22-6(2024-03-20); lazyeval 0.2.2(2019-03-15); lifecycle 1.0.4(2023-11-07); logger 0.4.0(2024-10-22); lubridate 1.9.4(2024-12-08); magick 2.8.6(2025-03-23); magrittr 2.0.3(2022-03-30); MASS 7.3-65(2025-02-28); Matrix 1.7-3(2025-03-11); MatrixGenerics 1.19.1(2025-03-26); matrixStats 1.5.0(2025-01-07); memoise 2.0.1(2021-11-26); mixtools 2.0.0.1(2025-03-08); munsell 0.5.1(2024-04-01); nlme 3.1-167(2025-01-27); OmnipathR 3.15.11(2025-03-26); parallelly 1.43.0(2025-03-24); pillar 1.10.1(2025-01-07); pkgconfig 2.0.3(2019-09-22); plotly 4.10.4(2024-01-13); png 0.1-8(2022-11-29); prettyunits 1.2.0(2023-09-24); processx 3.8.6(2025-02-21); progress 1.2.3(2023-12-06); promises 1.3.2(2024-11-28); proxy 0.4-27(2022-06-09); ps 1.9.0(2025-02-18); purrr 1.0.4(2025-02-05); R.methodsS3 1.8.2(2022-06-13); R.oo 1.27.0(2024-11-01); R.utils 2.13.0(2025-02-24); R6 2.6.1(2025-02-15); ranger 0.17.0(2024-11-08); rappdirs 0.3.3(2021-01-31); Rcpp 1.0.14(2025-01-12); readr 2.1.5(2024-01-10); readxl 1.4.5(2025-03-07); rhdf5 2.51.2(2025-03-26); rhdf5filters 1.19.2(2025-03-26); Rhdf5lib 1.29.2(2025-03-26); rjson 0.2.23(2024-09-16); rlang 1.1.5(2025-01-17); rmarkdown 2.29(2024-11-04); rpart 4.1.24(2025-01-07); RSQLite 2.3.9(2024-12-03); rsvd 1.0.5(2021-04-16); rvest 1.0.4(2024-02-12); S4Arrays 1.7.3(2025-03-26); S4Vectors 0.45.4(2025-03-26); ScaledMatrix 1.15.0(2025-03-26); scales 1.3.0(2023-11-28); segmented 2.1-4(2025-02-28); sessioninfo 1.2.3(2025-02-05); SingleCellExperiment 1.29.2(2025-03-26); SparseArray 1.7.7(2025-03-26); sparseMatrixStats 1.19.0(2025-03-26); SpatialExperiment 1.17.0(2025-03-26); stringi 1.8.4(2024-05-06); stringr 1.5.1(2023-11-14); SummarizedExperiment 1.37.0(2025-03-26); survival 3.8-3(2024-12-17); testthat 3.2.3(2025-01-13); tibble 3.2.1(2023-03-20); tidyr 1.3.1(2024-01-24); tidyselect 1.2.1(2024-03-11); timechange 0.3.0(2024-01-18); tzdb 0.5.0(2025-03-15); UCSC.utils 1.3.1(2025-03-26); vctrs 0.6.5(2023-12-01); viper 1.41.0(2025-03-26); viridisLite 0.4.2(2023-05-02); waldo 0.6.1(2024-11-07); websocket 1.4.2(2024-07-22); withr 3.0.2(2024-10-28); xfun 0.51(2025-02-19); XML 3.99-0.18(2025-01-01); xml2 1.3.8(2025-03-14); xtable 1.8-4(2019-04-21); XVector 0.47.2(2025-03-26); yaml 2.3.10(2024-07-26); zip 2.3.2(2025-02-01)
[2025-03-26 18:58:29] [INFO]    [OmnipathR] CURL: version: 8.11.1; headers: 8.11.1; ssl_version: OpenSSL/3.3.2 (SecureTransport); libz_version: 1.2.11; libssh_version: NA; libidn_version: NA; host: aarch64-apple-darwin23.6.0; protocols: dict, file, ftp, ftps, gopher, gophers, http, https, imap, imaps, ldap, ldaps, mqtt, pop3, pop3s, rtsp, smb, smbs, smtp, smtps, telnet, tftp, ws, wss; ipv6: TRUE; http2: TRUE; idn: FALSE; url_parser: TRUE
[2025-03-26 18:58:29] [TRACE]   [OmnipathR] Running on a build server, wiping cache.
[2025-03-26 18:58:29] [TRACE]   [OmnipathR] Cache is at `/Users/biocbuild/Library/Caches/OmnipathR`.
[2025-03-26 18:58:29] [TRACE]   [OmnipathR] Contains 8 files.
[2025-03-26 18:58:29] [TRACE]   [OmnipathR] Cache is locked: FALSE.
[2025-03-26 18:58:29] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-03-26 18:58:29] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-03-26 18:58:29] [SUCCESS] [OmnipathR] Removing all cache contents from `/Users/biocbuild/Library/Caches/OmnipathR`.
[2025-03-26 18:58:29] [TRACE]   [OmnipathR] Pandoc version: `3.1.12.3`.
[2025-03-26 18:58:29] [TRACE]   [OmnipathR] Reading JSON from `/Library/Frameworks/R.framework/Versions/4.5-arm64/Resources/library/OmnipathR/db/db_def.json` (encoding: UTF-8).
[2025-03-26 18:58:29] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-03-26 18:58:29] [TRACE]   [OmnipathR] Reading JSON from `/Library/Frameworks/R.framework/Versions/4.5-arm64/Resources/library/OmnipathR/internal/magic_bytes.json` (encoding: UTF-8).
[2025-03-26 18:58:29] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-03-26 18:58:29] [TRACE]   [OmnipathR] Reading JSON from `/Library/Frameworks/R.framework/Versions/4.5-arm64/Resources/library/OmnipathR/internal/urls.json` (encoding: UTF-8).
[2025-03-26 18:58:29] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-03-26 18:58:29] [TRACE]   [OmnipathR] Reading JSON from `/Library/Frameworks/R.framework/Versions/4.5-arm64/Resources/library/OmnipathR/internal/id_types.json` (encoding: UTF-8).
[2025-03-26 18:58:29] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-03-26 18:58:29] [TRACE]   [OmnipathR] Cache locked: FALSE
[2025-03-26 18:58:29] [TRACE]   [OmnipathR] Reading JSON from `https://omnipathdb.org/resources` (encoding: UTF-8).
[2025-03-26 18:58:29] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-03-26 18:58:30] [TRACE]   [OmnipathR] Reading JSON from `https://omnipathdb.org/resources` (encoding: UTF-8).
[2025-03-26 18:58:30] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-03-26 18:58:30] [INFO]    [OmnipathR] Loading database `Ensembl and OMA organism names`.
[2025-03-26 18:58:30] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-03-26 18:58:30] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-03-26 18:58:30] [INFO]    [OmnipathR] Looking up in cache `https://www.ensembl.org/info/about/species.html`: key=7332486db7400730697234bad76ca0c8e4d00799, no version available.
[2025-03-26 18:58:30] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-03-26 18:58:30] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-03-26 18:58:30] [INFO]    [OmnipathR] Created new version for cache record 7332486db7400730697234bad76ca0c8e4d00799: version 1.
[2025-03-26 18:58:30] [TRACE]   [OmnipathR] Cache file path: /Users/biocbuild/Library/Caches/OmnipathR/7332486db7400730697234bad76ca0c8e4d00799-1.html
[2025-03-26 18:58:30] [INFO]    [OmnipathR] Retrieving URL: `https://www.ensembl.org/info/about/species.html`
[2025-03-26 18:58:30] [TRACE]   [OmnipathR] Downloading by `httr2` in `download_base`.
[2025-03-26 18:58:30] [TRACE]   [OmnipathR] Attempt 1/3: `https://www.ensembl.org/info/about/species.html`
[2025-03-26 18:58:30] [TRACE]   [OmnipathR] Preparing httr2 request to URL `https://www.ensembl.org/info/about/species.html`.
[2025-03-26 18:58:30] [TRACE]   [OmnipathR] HTTP headers: [User-Agent=Mozilla/5.0 (X11; Linux x86_64; rv:134.0) Gecko/20100101 Firefox/134.0]
[2025-03-26 18:58:30] [TRACE]   [OmnipathR] Curl options: [connecttimeout=10,timeout=300,debugfunction=<function>,verbose=FALSE,tcp_keepalive=TRUE,tcp_keepintvl=10,tcp_keepidle=10,tcp_keepcnt=13,upkeep_interval_ms=30000,ssl_verifypeer=1,ssl_verifyhost=2]
[2025-03-26 18:58:30] [TRACE]   [OmnipathR] HTTP headers: [User-Agent=Mozilla/5.0 (X11; Linux x86_64; rv:134.0) Gecko/20100101 Firefox/134.0]
[2025-03-26 18:58:30] [TRACE]   [OmnipathR] Sending HTTP request.
[2025-03-26 18:58:31] [TRACE]   [OmnipathR] HTTP 200 (OK)
[2025-03-26 18:58:31] [TRACE]   [OmnipathR] Downloaded 31 Kb in 1.205641s from www.ensembl.org (25.7 Kb/s); Redirect: 0.995093s, DNS look up: 0.003379s, Connection: 0.004872s, Pretransfer: 0.57319s, First byte at: 1.179858s
[2025-03-26 18:58:31] [TRACE]   [OmnipathR] Response headers: [date=Wed, 26 Mar 2025 22:58:31 GMT,content-type=text/html; charset=utf-8,content-length=31716,server=Apache,set-cookie=redirect_mirror=; path=/; expires=Mon, 01-Jan-2001 00:00:01 GMT,set-cookie=redirect_mirror=no; path=/; expires=Thu, 27 Mar 2025 22:46:30 GMT,set-cookie=ENSEMBL_WWW_SESSION=2422b7862e2d1a43082a97da68339dc6001539b89bc960bec8e2defe; path=/; expires=Thu, 31-Dec-2037 23:59:59 GMT; HttpOnly,set-cookie=redirect_mirror=; path=/; expires=Mon, 01-Jan-2001 00:00:01 GMT,set-cookie=redirect_mirror=no; path=/; expires=Thu, 27 Mar 2025 22:46:30 GMT,set-cookie=ENSEMBL_WWW_SESSION=2422b7862e2d1a43082a97da68339dc6001539b89bc960bec8e2defe; path=/; expires=Thu, 31-Dec-2037 23:59:59 GMT; HttpOnly,vary=Accept-Encoding,content-encoding=gzip,x-frame-options=SAMEORIGIN,content-security-policy=frame-ancestors 'self',x-nginx-machine=ip-10-25-25-78.us-east-2.compute.internal]
[2025-03-26 18:58:32] [INFO]    [OmnipathR] Download ready [key=7332486db7400730697234bad76ca0c8e4d00799, version=1]
[2025-03-26 18:58:32] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-03-26 18:58:32] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-03-26 18:58:32] [INFO]    [OmnipathR] Cache item `7332486db7400730697234bad76ca0c8e4d00799` version 1: status changed from `unknown` to `ready`.
[2025-03-26 18:58:32] [TRACE]   [OmnipathR] Downloading by `generic_downloader`.
[2025-03-26 18:58:32] [TRACE]   [OmnipathR] Looking up in cache: `https://omabrowser.org/All/oma-species.txt`.
[2025-03-26 18:58:32] [INFO]    [OmnipathR] Cache record does not exist: `https://omabrowser.org/All/oma-species.txt`
[2025-03-26 18:58:32] [TRACE]   [OmnipathR] Could not find in cache, initiating download: `https://omabrowser.org/All/oma-species.txt`.
[2025-03-26 18:58:32] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-03-26 18:58:32] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-03-26 18:58:32] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-03-26 18:58:32] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-03-26 18:58:32] [INFO]    [OmnipathR] Cache item `30e690cbb55dfc63b5903ab337f34ffc2f4be397` version 1: status changed from `unknown` to `started`.
[2025-03-26 18:58:32] [TRACE]   [OmnipathR] Exporting object to RDS: `/Users/biocbuild/Library/Caches/OmnipathR/30e690cbb55dfc63b5903ab337f34ffc2f4be397-1.rds`.
[2025-03-26 18:58:32] [INFO]    [OmnipathR] Retrieving URL: `https://omabrowser.org/All/oma-species.txt`
[2025-03-26 18:58:32] [TRACE]   [OmnipathR] Attempt 1/3: `https://omabrowser.org/All/oma-species.txt`
[2025-03-26 18:58:32] [TRACE]   [OmnipathR] Curl options: [connecttimeout=10,timeout=300,debugfunction=<function>,verbose=FALSE,tcp_keepalive=TRUE,tcp_keepintvl=10,tcp_keepidle=10,tcp_keepcnt=13,upkeep_interval_ms=30000,ssl_verifypeer=1,ssl_verifyhost=2]
[2025-03-26 18:58:33] [TRACE]   [OmnipathR] Downloaded 130.3 Kb in 1.246434s from omabrowser.org (104.5 Kb/s); Redirect: 0s, DNS look up: 0.199204s, Connection: 0.200859s, Pretransfer: 0.528893s, First byte at: 0.612274s
[2025-03-26 18:58:34] [TRACE]   [OmnipathR] Exported RDS to `/Users/biocbuild/Library/Caches/OmnipathR/30e690cbb55dfc63b5903ab337f34ffc2f4be397-1.rds`.
[2025-03-26 18:58:34] [INFO]    [OmnipathR] Download ready [key=30e690cbb55dfc63b5903ab337f34ffc2f4be397, version=1]
[2025-03-26 18:58:34] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-03-26 18:58:34] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-03-26 18:58:34] [INFO]    [OmnipathR] Cache item `30e690cbb55dfc63b5903ab337f34ffc2f4be397` version 1: status changed from `started` to `ready`.
[2025-03-26 18:58:34] [INFO]    [OmnipathR] Loaded database `Ensembl and OMA organism names`.
[2025-03-26 18:58:34] [TRACE]   [OmnipathR] Processing args for OmniPath query
[2025-03-26 18:58:34] [TRACE]   [OmnipathR] Arguments for OmniPath query: [wide=TRUE,resources=TFcensus,query_type=annotations]
[2025-03-26 18:58:34] [TRACE]   [OmnipathR] Organism(s): 9606
[2025-03-26 18:58:34] [TRACE]   [OmnipathR] Orthology targets: 
[2025-03-26 18:58:34] [TRACE]   [OmnipathR] Reading JSON from `https://omnipathdb.org/resources` (encoding: UTF-8).
[2025-03-26 18:58:34] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-03-26 18:58:34] [TRACE]   [OmnipathR] Looking up in cache: `https://omnipathdb.org/annotations?resources=TFcensus&license=academic`
[2025-03-26 18:58:34] [INFO]    [OmnipathR] Cache record does not exist: `https://omnipathdb.org/annotations?resources=TFcensus&license=academic`
[2025-03-26 18:58:34] [TRACE]   [OmnipathR] Looking up in cache: `http://no-tls.omnipathdb.org/annotations?resources=TFcensus&license=academic`
[2025-03-26 18:58:34] [INFO]    [OmnipathR] Cache record does not exist: `http://no-tls.omnipathdb.org/annotations?resources=TFcensus&license=academic`
[2025-03-26 18:58:34] [TRACE]   [OmnipathR] Attempting `https://omnipathdb.org/annotations?resources=TFcensus&license=academic`
[2025-03-26 18:58:34] [INFO]    [OmnipathR] Retrieving URL: `https://omnipathdb.org/annotations?resources=TFcensus&license=academic`
[2025-03-26 18:58:34] [TRACE]   [OmnipathR] Attempt 1/3: `https://omnipathdb.org/annotations?resources=TFcensus&license=academic`
[2025-03-26 18:58:34] [TRACE]   [OmnipathR] Curl options: [connecttimeout=10,timeout=300,debugfunction=<function>,verbose=FALSE,tcp_keepalive=TRUE,tcp_keepintvl=10,tcp_keepidle=10,tcp_keepcnt=13,upkeep_interval_ms=30000,ssl_verifypeer=1,ssl_verifyhost=2]
[2025-03-26 18:58:35] [TRACE]   [OmnipathR] Downloaded 29.2 Kb in 0.477526s from omnipathdb.org (61.1 Kb/s); Redirect: 0s, DNS look up: 0.000977s, Connection: 0.00246s, Pretransfer: 0.156128s, First byte at: 0.401819s
[2025-03-26 18:58:35] [INFO]    [OmnipathR] Successfully retrieved: `https://omnipathdb.org/annotations?resources=TFcensus&license=academic`
[2025-03-26 18:58:35] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-03-26 18:58:35] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-03-26 18:58:35] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-03-26 18:58:35] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-03-26 18:58:35] [INFO]    [OmnipathR] Cache item `6f000d9b5edd9832b1c28754d1c3d9449c1c7490` version 1: status changed from `unknown` to `started`.
[2025-03-26 18:58:35] [TRACE]   [OmnipathR] Exporting object to RDS: `/Users/biocbuild/Library/Caches/OmnipathR/6f000d9b5edd9832b1c28754d1c3d9449c1c7490-1.rds`.
[2025-03-26 18:58:35] [TRACE]   [OmnipathR] Exported RDS to `/Users/biocbuild/Library/Caches/OmnipathR/6f000d9b5edd9832b1c28754d1c3d9449c1c7490-1.rds`.
[2025-03-26 18:58:35] [INFO]    [OmnipathR] Download ready [key=6f000d9b5edd9832b1c28754d1c3d9449c1c7490, version=1]
[2025-03-26 18:58:35] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-03-26 18:58:35] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-03-26 18:58:35] [INFO]    [OmnipathR] Cache item `6f000d9b5edd9832b1c28754d1c3d9449c1c7490` version 1: status changed from `started` to `ready`.
[2025-03-26 18:58:35] [SUCCESS] [OmnipathR] Downloaded 3099 annotation records.
[2025-03-26 18:58:36] [TRACE]   [OmnipathR] Reading JSON from `https://omnipathdb.org/resources` (encoding: UTF-8).
[2025-03-26 18:58:36] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-03-26 18:58:36] [TRACE]   [OmnipathR] Processing args for OmniPath query
[2025-03-26 18:58:36] [TRACE]   [OmnipathR] Arguments for OmniPath query: [wide=TRUE,resources=PROGENy,query_type=annotations]
[2025-03-26 18:58:36] [TRACE]   [OmnipathR] Organism(s): 9606
[2025-03-26 18:58:36] [TRACE]   [OmnipathR] Orthology targets: 
[2025-03-26 18:58:37] [TRACE]   [OmnipathR] Reading JSON from `https://omnipathdb.org/resources` (encoding: UTF-8).
[2025-03-26 18:58:37] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-03-26 18:58:37] [TRACE]   [OmnipathR] Looking up in cache: `https://omnipathdb.org/annotations?resources=PROGENy&license=academic`
[2025-03-26 18:58:37] [INFO]    [OmnipathR] Cache record does not exist: `https://omnipathdb.org/annotations?resources=PROGENy&license=academic`
[2025-03-26 18:58:37] [TRACE]   [OmnipathR] Looking up in cache: `http://no-tls.omnipathdb.org/annotations?resources=PROGENy&license=academic`
[2025-03-26 18:58:37] [INFO]    [OmnipathR] Cache record does not exist: `http://no-tls.omnipathdb.org/annotations?resources=PROGENy&license=academic`
[2025-03-26 18:58:37] [TRACE]   [OmnipathR] Attempting `https://omnipathdb.org/annotations?resources=PROGENy&license=academic`
[2025-03-26 18:58:37] [INFO]    [OmnipathR] Retrieving URL: `https://omnipathdb.org/annotations?resources=PROGENy&license=academic`
[2025-03-26 18:58:37] [TRACE]   [OmnipathR] Attempt 1/3: `https://omnipathdb.org/annotations?resources=PROGENy&license=academic`
[2025-03-26 18:58:37] [TRACE]   [OmnipathR] Curl options: [connecttimeout=10,timeout=300,debugfunction=<function>,verbose=FALSE,tcp_keepalive=TRUE,tcp_keepintvl=10,tcp_keepidle=10,tcp_keepcnt=13,upkeep_interval_ms=30000,ssl_verifypeer=1,ssl_verifyhost=2]
[2025-03-26 18:58:44] [TRACE]   [OmnipathR] Downloaded 8.9 Mb in 7.100585s from omnipathdb.org (1.3 Mb/s); Redirect: 0s, DNS look up: 0.000967s, Connection: 0.001867s, Pretransfer: 0.167671s, First byte at: 0.331074s
[2025-03-26 18:58:45] [INFO]    [OmnipathR] Successfully retrieved: `https://omnipathdb.org/annotations?resources=PROGENy&license=academic`
[2025-03-26 18:58:45] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-03-26 18:58:45] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-03-26 18:58:45] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-03-26 18:58:45] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-03-26 18:58:45] [INFO]    [OmnipathR] Cache item `3492392585ba05414edfae46801492076437d7e7` version 1: status changed from `unknown` to `started`.
[2025-03-26 18:58:45] [TRACE]   [OmnipathR] Exporting object to RDS: `/Users/biocbuild/Library/Caches/OmnipathR/3492392585ba05414edfae46801492076437d7e7-1.rds`.
[2025-03-26 18:58:46] [TRACE]   [OmnipathR] Exported RDS to `/Users/biocbuild/Library/Caches/OmnipathR/3492392585ba05414edfae46801492076437d7e7-1.rds`.
[2025-03-26 18:58:46] [INFO]    [OmnipathR] Download ready [key=3492392585ba05414edfae46801492076437d7e7, version=1]
[2025-03-26 18:58:46] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-03-26 18:58:46] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-03-26 18:58:46] [INFO]    [OmnipathR] Cache item `3492392585ba05414edfae46801492076437d7e7` version 1: status changed from `started` to `ready`.
[2025-03-26 18:58:46] [SUCCESS] [OmnipathR] Downloaded 700239 annotation records.
[2025-03-26 18:58:47] [TRACE]   [OmnipathR] Reading JSON from `https://omnipathdb.org/resources` (encoding: UTF-8).
[2025-03-26 18:58:47] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-03-26 18:58:47] [TRACE]   [OmnipathR] Processing args for OmniPath query
[2025-03-26 18:58:47] [TRACE]   [OmnipathR] Arguments for OmniPath query: [wide=TRUE,resources=PROGENy,query_type=annotations]
[2025-03-26 18:58:47] [TRACE]   [OmnipathR] Organism(s): 9606
[2025-03-26 18:58:47] [TRACE]   [OmnipathR] Orthology targets: 
[2025-03-26 18:58:48] [TRACE]   [OmnipathR] Reading JSON from `https://omnipathdb.org/resources` (encoding: UTF-8).
[2025-03-26 18:58:48] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-03-26 18:58:48] [TRACE]   [OmnipathR] Looking up in cache: `https://omnipathdb.org/annotations?resources=PROGENy&license=academic`
[2025-03-26 18:58:49] [TRACE]   [OmnipathR] Loaded data from RDS `/Users/biocbuild/Library/Caches/OmnipathR/3492392585ba05414edfae46801492076437d7e7-1.rds`.
[2025-03-26 18:58:49] [INFO]    [OmnipathR] Loaded from cache: `https://omnipathdb.org/annotations?resources=PROGENy&license=academic`
[2025-03-26 18:58:49] [SUCCESS] [OmnipathR] Loaded 700239 annotation records from cache.
[2025-03-26 18:58:50] [INFO]    [OmnipathR] Loading database `Orthologous Matrix (OMA) gene pairs`.
[2025-03-26 18:58:50] [TRACE]   [OmnipathR] Downloading by `generic_downloader`.
[2025-03-26 18:58:50] [TRACE]   [OmnipathR] Looking up in cache: `https://omabrowser.org/All/oma-species.txt`.
[2025-03-26 18:58:50] [TRACE]   [OmnipathR] Loaded data from RDS `/Users/biocbuild/Library/Caches/OmnipathR/30e690cbb55dfc63b5903ab337f34ffc2f4be397-1.rds`.
[2025-03-26 18:58:50] [TRACE]   [OmnipathR] Downloading by `generic_downloader`.
[2025-03-26 18:58:50] [TRACE]   [OmnipathR] Looking up in cache: `https://omabrowser.org/All/oma-species.txt`.
[2025-03-26 18:58:50] [TRACE]   [OmnipathR] Loaded data from RDS `/Users/biocbuild/Library/Caches/OmnipathR/30e690cbb55dfc63b5903ab337f34ffc2f4be397-1.rds`.
[2025-03-26 18:58:50] [TRACE]   [OmnipathR] Downloading by `generic_downloader`.
[2025-03-26 18:58:50] [TRACE]   [OmnipathR] Looking up in cache: `https://omabrowser.org/api/pairs/HUMAN/MOUSE/?format=tsv&xrefs=UniProtKB%2FSwissProt&per_page=2000000`.
[2025-03-26 18:58:50] [INFO]    [OmnipathR] Cache record does not exist: `https://omabrowser.org/api/pairs/HUMAN/MOUSE/?format=tsv&xrefs=UniProtKB%2FSwissProt&per_page=2000000`
[2025-03-26 18:58:50] [TRACE]   [OmnipathR] Could not find in cache, initiating download: `https://omabrowser.org/api/pairs/HUMAN/MOUSE/?format=tsv&xrefs=UniProtKB%2FSwissProt&per_page=2000000`.
[2025-03-26 18:58:50] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-03-26 18:58:50] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-03-26 18:58:50] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-03-26 18:58:50] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-03-26 18:58:50] [INFO]    [OmnipathR] Cache item `8f45b25c384d814c7de210e7ca40b7e35894e4f1` version 1: status changed from `unknown` to `started`.
[2025-03-26 18:58:50] [TRACE]   [OmnipathR] Exporting object to RDS: `/Users/biocbuild/Library/Caches/OmnipathR/8f45b25c384d814c7de210e7ca40b7e35894e4f1-1.rds`.
[2025-03-26 18:58:50] [INFO]    [OmnipathR] Retrieving URL: `https://omabrowser.org/api/pairs/HUMAN/MOUSE/?format=tsv&xrefs=UniProtKB%2FSwissProt&per_page=2000000`
[2025-03-26 18:58:50] [TRACE]   [OmnipathR] Attempt 1/3: `https://omabrowser.org/api/pairs/HUMAN/MOUSE/?format=tsv&xrefs=UniProtKB%2FSwissProt&per_page=2000000`
[2025-03-26 18:58:50] [TRACE]   [OmnipathR] Curl options: [connecttimeout=10,timeout=300,debugfunction=<function>,verbose=FALSE,tcp_keepalive=TRUE,tcp_keepintvl=10,tcp_keepidle=10,tcp_keepcnt=13,upkeep_interval_ms=30000,ssl_verifypeer=1,ssl_verifyhost=2]
[2025-03-26 18:59:20] [TRACE]   [OmnipathR] Downloaded 1.1 Mb in 29.910507s from omabrowser.org (38.8 Kb/s); Redirect: 0s, DNS look up: 0.000974s, Connection: 0.001808s, Pretransfer: 0.167987s, First byte at: 28.248128s
[2025-03-26 18:59:20] [TRACE]   [OmnipathR] Exported RDS to `/Users/biocbuild/Library/Caches/OmnipathR/8f45b25c384d814c7de210e7ca40b7e35894e4f1-1.rds`.
[2025-03-26 18:59:20] [INFO]    [OmnipathR] Download ready [key=8f45b25c384d814c7de210e7ca40b7e35894e4f1, version=1]
[2025-03-26 18:59:20] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-03-26 18:59:20] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-03-26 18:59:20] [INFO]    [OmnipathR] Cache item `8f45b25c384d814c7de210e7ca40b7e35894e4f1` version 1: status changed from `started` to `ready`.
[2025-03-26 18:59:20] [TRACE]   [OmnipathR] ID translation table: from `uniprot_entry` to `uniprot`, using `uniprot`.
[2025-03-26 18:59:20] [TRACE]   [OmnipathR] Creating ID mapping table from `id` to `accession`, for organism 9606 (only reviewed: TRUE)
[2025-03-26 18:59:20] [TRACE]   [OmnipathR] Loading all UniProt records for organism 9606 (only reviewed: TRUE); fields: id,accession
[2025-03-26 18:59:20] [TRACE]   [OmnipathR] Downloading by `generic_downloader`.
[2025-03-26 18:59:20] [TRACE]   [OmnipathR] Looking up in cache: `https://rest.uniprot.org/uniprotkb/stream?format=tsv&fields=id,accession&query=organism_id:9606%20AND%20reviewed:true`.
[2025-03-26 18:59:20] [INFO]    [OmnipathR] Cache record does not exist: `https://rest.uniprot.org/uniprotkb/stream?format=tsv&fields=id,accession&query=organism_id:9606%20AND%20reviewed:true`
[2025-03-26 18:59:20] [TRACE]   [OmnipathR] Could not find in cache, initiating download: `https://rest.uniprot.org/uniprotkb/stream?format=tsv&fields=id,accession&query=organism_id:9606%20AND%20reviewed:true`.
[2025-03-26 18:59:20] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-03-26 18:59:20] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-03-26 18:59:20] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-03-26 18:59:20] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-03-26 18:59:20] [INFO]    [OmnipathR] Cache item `6558a1824894a625b8e3f80538cd3aa6e8a44379` version 1: status changed from `unknown` to `started`.
[2025-03-26 18:59:20] [TRACE]   [OmnipathR] Exporting object to RDS: `/Users/biocbuild/Library/Caches/OmnipathR/6558a1824894a625b8e3f80538cd3aa6e8a44379-1.rds`.
[2025-03-26 18:59:20] [INFO]    [OmnipathR] Retrieving URL: `https://rest.uniprot.org/uniprotkb/stream?format=tsv&fields=id,accession&query=organism_id:9606%20AND%20reviewed:true`
[2025-03-26 18:59:21] [TRACE]   [OmnipathR] Attempt 1/3: `https://rest.uniprot.org/uniprotkb/stream?format=tsv&fields=id,accession&query=organism_id:9606%20AND%20reviewed:true`
[2025-03-26 18:59:21] [TRACE]   [OmnipathR] Curl options: [connecttimeout=10,timeout=300,debugfunction=<function>,verbose=FALSE,tcp_keepalive=TRUE,tcp_keepintvl=10,tcp_keepidle=10,tcp_keepcnt=13,upkeep_interval_ms=30000,ssl_verifypeer=1,ssl_verifyhost=2]
[2025-03-26 18:59:39] [TRACE]   [OmnipathR] Downloaded 128.7 Kb in 18.159384s from rest.uniprot.org (7.1 Kb/s); Redirect: 0s, DNS look up: 0.006204s, Connection: 0.0082s, Pretransfer: 0.637737s, First byte at: 1.232944s
[2025-03-26 18:59:39] [TRACE]   [OmnipathR] Exported RDS to `/Users/biocbuild/Library/Caches/OmnipathR/6558a1824894a625b8e3f80538cd3aa6e8a44379-1.rds`.
[2025-03-26 18:59:39] [INFO]    [OmnipathR] Download ready [key=6558a1824894a625b8e3f80538cd3aa6e8a44379, version=1]
[2025-03-26 18:59:39] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-03-26 18:59:39] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-03-26 18:59:39] [INFO]    [OmnipathR] Cache item `6558a1824894a625b8e3f80538cd3aa6e8a44379` version 1: status changed from `started` to `ready`.
[2025-03-26 18:59:39] [SUCCESS] [OmnipathR] UniProt (rest.uniprot.org): downloaded 20417 records
[2025-03-26 18:59:40] [TRACE]   [OmnipathR] Translating complexes: 0 complexes in data.
[2025-03-26 18:59:40] [TRACE]   [OmnipathR] 0 complexes after removing the ones mapping to more than 1 items in target identifier space.
[2025-03-26 18:59:40] [TRACE]   [OmnipathR] Translated 0 complexes to 0.
[2025-03-26 18:59:40] [TRACE]   [OmnipathR] 13774 rows before translation, 13774 uniprot_entry IDs in column `id_organism_a`.
[2025-03-26 18:59:40] [TRACE]   [OmnipathR] 13774 rows after translation; translated 13570 `uniprot_entry` IDs in column `id_organism_a` to 13570 `uniprot` IDs in column `id_organism_a`.
[2025-03-26 18:59:40] [TRACE]   [OmnipathR] ID translation table: from `uniprot_entry` to `uniprot`, using `uniprot`.
[2025-03-26 18:59:40] [TRACE]   [OmnipathR] Creating ID mapping table from `id` to `accession`, for organism 10090 (only reviewed: TRUE)
[2025-03-26 18:59:40] [TRACE]   [OmnipathR] Loading all UniProt records for organism 10090 (only reviewed: TRUE); fields: id,accession
[2025-03-26 18:59:40] [TRACE]   [OmnipathR] Downloading by `generic_downloader`.
[2025-03-26 18:59:40] [TRACE]   [OmnipathR] Looking up in cache: `https://rest.uniprot.org/uniprotkb/stream?format=tsv&fields=id,accession&query=organism_id:10090%20AND%20reviewed:true`.
[2025-03-26 18:59:40] [INFO]    [OmnipathR] Cache record does not exist: `https://rest.uniprot.org/uniprotkb/stream?format=tsv&fields=id,accession&query=organism_id:10090%20AND%20reviewed:true`
[2025-03-26 18:59:40] [TRACE]   [OmnipathR] Could not find in cache, initiating download: `https://rest.uniprot.org/uniprotkb/stream?format=tsv&fields=id,accession&query=organism_id:10090%20AND%20reviewed:true`.
[2025-03-26 18:59:40] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-03-26 18:59:40] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-03-26 18:59:40] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-03-26 18:59:40] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-03-26 18:59:40] [INFO]    [OmnipathR] Cache item `43ea5f2cdaa9ac7e0e114371af97235cdddd776f` version 1: status changed from `unknown` to `started`.
[2025-03-26 18:59:40] [TRACE]   [OmnipathR] Exporting object to RDS: `/Users/biocbuild/Library/Caches/OmnipathR/43ea5f2cdaa9ac7e0e114371af97235cdddd776f-1.rds`.
[2025-03-26 18:59:40] [INFO]    [OmnipathR] Retrieving URL: `https://rest.uniprot.org/uniprotkb/stream?format=tsv&fields=id,accession&query=organism_id:10090%20AND%20reviewed:true`
[2025-03-26 18:59:40] [TRACE]   [OmnipathR] Attempt 1/3: `https://rest.uniprot.org/uniprotkb/stream?format=tsv&fields=id,accession&query=organism_id:10090%20AND%20reviewed:true`
[2025-03-26 18:59:40] [TRACE]   [OmnipathR] Curl options: [connecttimeout=10,timeout=300,debugfunction=<function>,verbose=FALSE,tcp_keepalive=TRUE,tcp_keepintvl=10,tcp_keepidle=10,tcp_keepcnt=13,upkeep_interval_ms=30000,ssl_verifypeer=1,ssl_verifyhost=2]
[2025-03-26 18:59:50] [TRACE]   [OmnipathR] Downloaded 110.4 Kb in 10.349904s from rest.uniprot.org (10.7 Kb/s); Redirect: 0s, DNS look up: 0.007434s, Connection: 0.010053s, Pretransfer: 0.488103s, First byte at: 0.93298s
[2025-03-26 18:59:51] [TRACE]   [OmnipathR] Exported RDS to `/Users/biocbuild/Library/Caches/OmnipathR/43ea5f2cdaa9ac7e0e114371af97235cdddd776f-1.rds`.
[2025-03-26 18:59:51] [INFO]    [OmnipathR] Download ready [key=43ea5f2cdaa9ac7e0e114371af97235cdddd776f, version=1]
[2025-03-26 18:59:51] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-03-26 18:59:51] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-03-26 18:59:51] [INFO]    [OmnipathR] Cache item `43ea5f2cdaa9ac7e0e114371af97235cdddd776f` version 1: status changed from `started` to `ready`.
[2025-03-26 18:59:51] [SUCCESS] [OmnipathR] UniProt (rest.uniprot.org): downloaded 17228 records
[2025-03-26 18:59:51] [TRACE]   [OmnipathR] Translating complexes: 0 complexes in data.
[2025-03-26 18:59:51] [TRACE]   [OmnipathR] 0 complexes after removing the ones mapping to more than 1 items in target identifier space.
[2025-03-26 18:59:51] [TRACE]   [OmnipathR] Translated 0 complexes to 0.
[2025-03-26 18:59:51] [TRACE]   [OmnipathR] 13774 rows before translation, 13773 uniprot_entry IDs in column `id_organism_b`.
[2025-03-26 18:59:51] [TRACE]   [OmnipathR] 13774 rows after translation; translated 13273 `uniprot_entry` IDs in column `id_organism_b` to 13273 `uniprot` IDs in column `id_organism_b`.
[2025-03-26 18:59:51] [INFO]    [OmnipathR] Loaded database `Orthologous Matrix (OMA) gene pairs`.
[2025-03-26 18:59:51] [TRACE]   [OmnipathR] ID translation table: from `uniprot` to `genesymbol`, using `uniprot`.
[2025-03-26 18:59:51] [TRACE]   [OmnipathR] Creating ID mapping table from `accession` to `gene_primary`, for organism 10090 (only reviewed: TRUE)
[2025-03-26 18:59:51] [TRACE]   [OmnipathR] Loading all UniProt records for organism 10090 (only reviewed: TRUE); fields: accession,gene_primary
[2025-03-26 18:59:51] [TRACE]   [OmnipathR] Downloading by `generic_downloader`.
[2025-03-26 18:59:51] [TRACE]   [OmnipathR] Looking up in cache: `https://rest.uniprot.org/uniprotkb/stream?format=tsv&fields=accession,gene_primary&query=organism_id:10090%20AND%20reviewed:true`.
[2025-03-26 18:59:51] [INFO]    [OmnipathR] Cache record does not exist: `https://rest.uniprot.org/uniprotkb/stream?format=tsv&fields=accession,gene_primary&query=organism_id:10090%20AND%20reviewed:true`
[2025-03-26 18:59:51] [TRACE]   [OmnipathR] Could not find in cache, initiating download: `https://rest.uniprot.org/uniprotkb/stream?format=tsv&fields=accession,gene_primary&query=organism_id:10090%20AND%20reviewed:true`.
[2025-03-26 18:59:51] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-03-26 18:59:51] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-03-26 18:59:51] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-03-26 18:59:51] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-03-26 18:59:51] [INFO]    [OmnipathR] Cache item `3ec84ba713c02573704adb50f1a94dab684df34b` version 1: status changed from `unknown` to `started`.
[2025-03-26 18:59:51] [TRACE]   [OmnipathR] Exporting object to RDS: `/Users/biocbuild/Library/Caches/OmnipathR/3ec84ba713c02573704adb50f1a94dab684df34b-1.rds`.
[2025-03-26 18:59:51] [INFO]    [OmnipathR] Retrieving URL: `https://rest.uniprot.org/uniprotkb/stream?format=tsv&fields=accession,gene_primary&query=organism_id:10090%20AND%20reviewed:true`
[2025-03-26 18:59:51] [TRACE]   [OmnipathR] Attempt 1/3: `https://rest.uniprot.org/uniprotkb/stream?format=tsv&fields=accession,gene_primary&query=organism_id:10090%20AND%20reviewed:true`
[2025-03-26 18:59:51] [TRACE]   [OmnipathR] Curl options: [connecttimeout=10,timeout=300,debugfunction=<function>,verbose=FALSE,tcp_keepalive=TRUE,tcp_keepintvl=10,tcp_keepidle=10,tcp_keepcnt=13,upkeep_interval_ms=30000,ssl_verifypeer=1,ssl_verifyhost=2]
[2025-03-26 19:02:17] [TRACE]   [OmnipathR] Downloaded 110.4 Kb in 2m 25.177007s from rest.uniprot.org (778 bytes/s); Redirect: 0s, DNS look up: 0.001391s, Connection: 0.003259s, Pretransfer: 0.249083s, First byte at: 1.856737s
[2025-03-26 19:02:17] [TRACE]   [OmnipathR] Exported RDS to `/Users/biocbuild/Library/Caches/OmnipathR/3ec84ba713c02573704adb50f1a94dab684df34b-1.rds`.
[2025-03-26 19:02:17] [INFO]    [OmnipathR] Download ready [key=3ec84ba713c02573704adb50f1a94dab684df34b, version=1]
[2025-03-26 19:02:17] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-03-26 19:02:17] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-03-26 19:02:17] [INFO]    [OmnipathR] Cache item `3ec84ba713c02573704adb50f1a94dab684df34b` version 1: status changed from `started` to `ready`.
[2025-03-26 19:02:17] [SUCCESS] [OmnipathR] UniProt (rest.uniprot.org): downloaded 17228 records
[2025-03-26 19:02:17] [TRACE]   [OmnipathR] Translating complexes: 0 complexes in data.
[2025-03-26 19:02:17] [TRACE]   [OmnipathR] 0 complexes after removing the ones mapping to more than 1 items in target identifier space.
[2025-03-26 19:02:17] [TRACE]   [OmnipathR] Translated 0 complexes to 0.
[2025-03-26 19:02:17] [TRACE]   [OmnipathR] 164184 rows before translation, 12877 uniprot IDs in column `uniprot`.
[2025-03-26 19:02:17] [TRACE]   [OmnipathR] 164184 rows after translation; translated 12877 `uniprot` IDs in column `uniprot` to 12790 `genesymbol` IDs in column `genesymbol`.
[2025-03-26 19:02:17] [TRACE]   [OmnipathR] Processing args for OmniPath query
[2025-03-26 19:02:17] [TRACE]   [OmnipathR] Arguments for OmniPath query: [dorothea_levels=[A,B,C,D],genesymbols=TRUE,organisms=9606,query_type=interactions,datasets=dorothea]
[2025-03-26 19:02:17] [TRACE]   [OmnipathR] Organism(s): 9606
[2025-03-26 19:02:17] [TRACE]   [OmnipathR] Orthology targets: 
[2025-03-26 19:02:17] [TRACE]   [OmnipathR] Looking up in cache: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=dorothea&organisms=9606&dorothea_levels=A,B,C,D&fields=sources,references,curation_effort,dorothea_level&license=academic`
[2025-03-26 19:02:17] [INFO]    [OmnipathR] Cache record does not exist: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=dorothea&organisms=9606&dorothea_levels=A,B,C,D&fields=sources,references,curation_effort,dorothea_level&license=academic`
[2025-03-26 19:02:17] [TRACE]   [OmnipathR] Looking up in cache: `http://no-tls.omnipathdb.org/interactions?genesymbols=yes&datasets=dorothea&organisms=9606&dorothea_levels=A,B,C,D&fields=sources,references,curation_effort,dorothea_level&license=academic`
[2025-03-26 19:02:17] [INFO]    [OmnipathR] Cache record does not exist: `http://no-tls.omnipathdb.org/interactions?genesymbols=yes&datasets=dorothea&organisms=9606&dorothea_levels=A,B,C,D&fields=sources,references,curation_effort,dorothea_level&license=academic`
[2025-03-26 19:02:17] [TRACE]   [OmnipathR] Attempting `https://omnipathdb.org/interactions?genesymbols=yes&datasets=dorothea&organisms=9606&dorothea_levels=A,B,C,D&fields=sources,references,curation_effort,dorothea_level&license=academic`
[2025-03-26 19:02:17] [INFO]    [OmnipathR] Retrieving URL: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=dorothea&organisms=9606&dorothea_levels=A,B,C,D&fields=sources,references,curation_effort,dorothea_level&license=academic`
[2025-03-26 19:02:17] [TRACE]   [OmnipathR] Attempt 1/3: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=dorothea&organisms=9606&dorothea_levels=A,B,C,D&fields=sources,references,curation_effort,dorothea_level&license=academic`
[2025-03-26 19:02:17] [TRACE]   [OmnipathR] Curl options: [connecttimeout=10,timeout=300,debugfunction=<function>,verbose=FALSE,tcp_keepalive=TRUE,tcp_keepintvl=10,tcp_keepidle=10,tcp_keepcnt=13,upkeep_interval_ms=30000,ssl_verifypeer=1,ssl_verifyhost=2]
[2025-03-26 19:02:21] [TRACE]   [OmnipathR] Downloaded 3.3 Mb in 3.425946s from omnipathdb.org (993.9 Kb/s); Redirect: 0s, DNS look up: 0.000834s, Connection: 0.001693s, Pretransfer: 0.309914s, First byte at: 0.473788s
[2025-03-26 19:02:21] [INFO]    [OmnipathR] Successfully retrieved: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=dorothea&organisms=9606&dorothea_levels=A,B,C,D&fields=sources,references,curation_effort,dorothea_level&license=academic`
[2025-03-26 19:02:21] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-03-26 19:02:21] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-03-26 19:02:21] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-03-26 19:02:21] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-03-26 19:02:21] [INFO]    [OmnipathR] Cache item `46d37339bbc3f9a05bb89ccb79278cf1233f5cdf` version 1: status changed from `unknown` to `started`.
[2025-03-26 19:02:21] [TRACE]   [OmnipathR] Exporting object to RDS: `/Users/biocbuild/Library/Caches/OmnipathR/46d37339bbc3f9a05bb89ccb79278cf1233f5cdf-1.rds`.
[2025-03-26 19:02:22] [TRACE]   [OmnipathR] Exported RDS to `/Users/biocbuild/Library/Caches/OmnipathR/46d37339bbc3f9a05bb89ccb79278cf1233f5cdf-1.rds`.
[2025-03-26 19:02:22] [INFO]    [OmnipathR] Download ready [key=46d37339bbc3f9a05bb89ccb79278cf1233f5cdf, version=1]
[2025-03-26 19:02:22] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-03-26 19:02:22] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-03-26 19:02:22] [INFO]    [OmnipathR] Cache item `46d37339bbc3f9a05bb89ccb79278cf1233f5cdf` version 1: status changed from `started` to `ready`.
[2025-03-26 19:02:25] [SUCCESS] [OmnipathR] Downloaded 278830 interactions.
[2025-03-26 19:02:29] [TRACE]   [OmnipathR] Processing args for OmniPath query
[2025-03-26 19:02:29] [TRACE]   [OmnipathR] Arguments for OmniPath query: [dorothea_levels=[A,B,C,D],genesymbols=TRUE,organisms=10090,query_type=interactions,datasets=dorothea]
[2025-03-26 19:02:29] [TRACE]   [OmnipathR] Organism(s): 10090
[2025-03-26 19:02:29] [TRACE]   [OmnipathR] Orthology targets: 
[2025-03-26 19:02:29] [TRACE]   [OmnipathR] Looking up in cache: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=dorothea&organisms=10090&dorothea_levels=A,B,C,D&fields=sources,references,curation_effort,dorothea_level&license=academic`
[2025-03-26 19:02:29] [INFO]    [OmnipathR] Cache record does not exist: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=dorothea&organisms=10090&dorothea_levels=A,B,C,D&fields=sources,references,curation_effort,dorothea_level&license=academic`
[2025-03-26 19:02:29] [TRACE]   [OmnipathR] Looking up in cache: `http://no-tls.omnipathdb.org/interactions?genesymbols=yes&datasets=dorothea&organisms=10090&dorothea_levels=A,B,C,D&fields=sources,references,curation_effort,dorothea_level&license=academic`
[2025-03-26 19:02:29] [INFO]    [OmnipathR] Cache record does not exist: `http://no-tls.omnipathdb.org/interactions?genesymbols=yes&datasets=dorothea&organisms=10090&dorothea_levels=A,B,C,D&fields=sources,references,curation_effort,dorothea_level&license=academic`
[2025-03-26 19:02:29] [TRACE]   [OmnipathR] Attempting `https://omnipathdb.org/interactions?genesymbols=yes&datasets=dorothea&organisms=10090&dorothea_levels=A,B,C,D&fields=sources,references,curation_effort,dorothea_level&license=academic`
[2025-03-26 19:02:29] [INFO]    [OmnipathR] Retrieving URL: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=dorothea&organisms=10090&dorothea_levels=A,B,C,D&fields=sources,references,curation_effort,dorothea_level&license=academic`
[2025-03-26 19:02:29] [TRACE]   [OmnipathR] Attempt 1/3: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=dorothea&organisms=10090&dorothea_levels=A,B,C,D&fields=sources,references,curation_effort,dorothea_level&license=academic`
[2025-03-26 19:02:29] [TRACE]   [OmnipathR] Curl options: [connecttimeout=10,timeout=300,debugfunction=<function>,verbose=FALSE,tcp_keepalive=TRUE,tcp_keepintvl=10,tcp_keepidle=10,tcp_keepcnt=13,upkeep_interval_ms=30000,ssl_verifypeer=1,ssl_verifyhost=2]
[2025-03-26 19:02:36] [TRACE]   [OmnipathR] Downloaded 2.9 Mb in 7.000418s from omnipathdb.org (418.9 Kb/s); Redirect: 0s, DNS look up: 0.000931s, Connection: 0.001778s, Pretransfer: 0.313382s, First byte at: 4.378058s
[2025-03-26 19:02:37] [INFO]    [OmnipathR] Successfully retrieved: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=dorothea&organisms=10090&dorothea_levels=A,B,C,D&fields=sources,references,curation_effort,dorothea_level&license=academic`
[2025-03-26 19:02:37] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-03-26 19:02:37] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-03-26 19:02:37] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-03-26 19:02:37] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-03-26 19:02:37] [INFO]    [OmnipathR] Cache item `ff347dedf78ef5e38c9c6d8eed291fa901aa3791` version 1: status changed from `unknown` to `started`.
[2025-03-26 19:02:37] [TRACE]   [OmnipathR] Exporting object to RDS: `/Users/biocbuild/Library/Caches/OmnipathR/ff347dedf78ef5e38c9c6d8eed291fa901aa3791-1.rds`.
[2025-03-26 19:02:37] [TRACE]   [OmnipathR] Exported RDS to `/Users/biocbuild/Library/Caches/OmnipathR/ff347dedf78ef5e38c9c6d8eed291fa901aa3791-1.rds`.
[2025-03-26 19:02:37] [INFO]    [OmnipathR] Download ready [key=ff347dedf78ef5e38c9c6d8eed291fa901aa3791, version=1]
[2025-03-26 19:02:37] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-03-26 19:02:37] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-03-26 19:02:37] [INFO]    [OmnipathR] Cache item `ff347dedf78ef5e38c9c6d8eed291fa901aa3791` version 1: status changed from `started` to `ready`.
[2025-03-26 19:02:40] [SUCCESS] [OmnipathR] Downloaded 234298 interactions.
[2025-03-26 19:02:43] [TRACE]   [OmnipathR] Processing args for OmniPath query
[2025-03-26 19:02:43] [TRACE]   [OmnipathR] Arguments for OmniPath query: [loops=TRUE,organisms=9606,genesymbols=TRUE,query_type=interactions,datasets=collectri]
[2025-03-26 19:02:43] [TRACE]   [OmnipathR] Organism(s): 9606
[2025-03-26 19:02:43] [TRACE]   [OmnipathR] Orthology targets: 
[2025-03-26 19:02:43] [TRACE]   [OmnipathR] Looking up in cache: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=collectri&organisms=9606&fields=sources,references,curation_effort&loops=yes&license=academic`
[2025-03-26 19:02:43] [INFO]    [OmnipathR] Cache record does not exist: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=collectri&organisms=9606&fields=sources,references,curation_effort&loops=yes&license=academic`
[2025-03-26 19:02:43] [TRACE]   [OmnipathR] Looking up in cache: `http://no-tls.omnipathdb.org/interactions?genesymbols=yes&datasets=collectri&organisms=9606&fields=sources,references,curation_effort&loops=yes&license=academic`
[2025-03-26 19:02:43] [INFO]    [OmnipathR] Cache record does not exist: `http://no-tls.omnipathdb.org/interactions?genesymbols=yes&datasets=collectri&organisms=9606&fields=sources,references,curation_effort&loops=yes&license=academic`
[2025-03-26 19:02:43] [TRACE]   [OmnipathR] Attempting `https://omnipathdb.org/interactions?genesymbols=yes&datasets=collectri&organisms=9606&fields=sources,references,curation_effort&loops=yes&license=academic`
[2025-03-26 19:02:43] [INFO]    [OmnipathR] Retrieving URL: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=collectri&organisms=9606&fields=sources,references,curation_effort&loops=yes&license=academic`
[2025-03-26 19:02:43] [TRACE]   [OmnipathR] Attempt 1/3: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=collectri&organisms=9606&fields=sources,references,curation_effort&loops=yes&license=academic`
[2025-03-26 19:02:43] [TRACE]   [OmnipathR] Curl options: [connecttimeout=10,timeout=300,debugfunction=<function>,verbose=FALSE,tcp_keepalive=TRUE,tcp_keepintvl=10,tcp_keepidle=10,tcp_keepcnt=13,upkeep_interval_ms=30000,ssl_verifypeer=1,ssl_verifyhost=2]
[2025-03-26 19:02:45] [TRACE]   [OmnipathR] Downloaded 1.5 Mb in 1.967928s from omnipathdb.org (757.4 Kb/s); Redirect: 0s, DNS look up: 0.001027s, Connection: 0.002092s, Pretransfer: 0.158377s, First byte at: 0.313183s
[2025-03-26 19:02:46] [INFO]    [OmnipathR] Successfully retrieved: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=collectri&organisms=9606&fields=sources,references,curation_effort&loops=yes&license=academic`
[2025-03-26 19:02:46] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-03-26 19:02:46] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-03-26 19:02:46] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-03-26 19:02:46] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-03-26 19:02:46] [INFO]    [OmnipathR] Cache item `b10176737ba43d460b13709623189f3911123779` version 1: status changed from `unknown` to `started`.
[2025-03-26 19:02:46] [TRACE]   [OmnipathR] Exporting object to RDS: `/Users/biocbuild/Library/Caches/OmnipathR/b10176737ba43d460b13709623189f3911123779-1.rds`.
[2025-03-26 19:02:46] [TRACE]   [OmnipathR] Exported RDS to `/Users/biocbuild/Library/Caches/OmnipathR/b10176737ba43d460b13709623189f3911123779-1.rds`.
[2025-03-26 19:02:46] [INFO]    [OmnipathR] Download ready [key=b10176737ba43d460b13709623189f3911123779, version=1]
[2025-03-26 19:02:46] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-03-26 19:02:46] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-03-26 19:02:46] [INFO]    [OmnipathR] Cache item `b10176737ba43d460b13709623189f3911123779` version 1: status changed from `started` to `ready`.
[2025-03-26 19:02:47] [SUCCESS] [OmnipathR] Downloaded 64958 interactions.
[2025-03-26 19:02:47] [TRACE]   [OmnipathR] Processing args for OmniPath query
[2025-03-26 19:02:47] [TRACE]   [OmnipathR] Arguments for OmniPath query: [genesymbols=TRUE,resources=CollecTRI,strict_evidences=TRUE,query_type=interactions,datasets=tf_mirna]
[2025-03-26 19:02:47] [TRACE]   [OmnipathR] Organism(s): 9606
[2025-03-26 19:02:47] [TRACE]   [OmnipathR] Orthology targets: 
[2025-03-26 19:02:48] [TRACE]   [OmnipathR] Reading JSON from `https://omnipathdb.org/resources` (encoding: UTF-8).
[2025-03-26 19:02:48] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-03-26 19:02:48] [TRACE]   [OmnipathR] Looking up in cache: `https://omnipathdb.org/interactions?genesymbols=yes&resources=CollecTRI&datasets=tf_mirna&organisms=9606&fields=evidences,sources,references,curation_effort&license=academic`
[2025-03-26 19:02:48] [INFO]    [OmnipathR] Cache record does not exist: `https://omnipathdb.org/interactions?genesymbols=yes&resources=CollecTRI&datasets=tf_mirna&organisms=9606&fields=evidences,sources,references,curation_effort&license=academic`
[2025-03-26 19:02:48] [TRACE]   [OmnipathR] Looking up in cache: `http://no-tls.omnipathdb.org/interactions?genesymbols=yes&resources=CollecTRI&datasets=tf_mirna&organisms=9606&fields=evidences,sources,references,curation_effort&license=academic`
[2025-03-26 19:02:48] [INFO]    [OmnipathR] Cache record does not exist: `http://no-tls.omnipathdb.org/interactions?genesymbols=yes&resources=CollecTRI&datasets=tf_mirna&organisms=9606&fields=evidences,sources,references,curation_effort&license=academic`
[2025-03-26 19:02:48] [TRACE]   [OmnipathR] Attempting `https://omnipathdb.org/interactions?genesymbols=yes&resources=CollecTRI&datasets=tf_mirna&organisms=9606&fields=evidences,sources,references,curation_effort&license=academic`
[2025-03-26 19:02:48] [INFO]    [OmnipathR] Retrieving URL: `https://omnipathdb.org/interactions?genesymbols=yes&resources=CollecTRI&datasets=tf_mirna&organisms=9606&fields=evidences,sources,references,curation_effort&license=academic`
[2025-03-26 19:02:48] [TRACE]   [OmnipathR] Attempt 1/3: `https://omnipathdb.org/interactions?genesymbols=yes&resources=CollecTRI&datasets=tf_mirna&organisms=9606&fields=evidences,sources,references,curation_effort&license=academic`
[2025-03-26 19:02:48] [TRACE]   [OmnipathR] Curl options: [connecttimeout=10,timeout=300,debugfunction=<function>,verbose=FALSE,tcp_keepalive=TRUE,tcp_keepintvl=10,tcp_keepidle=10,tcp_keepcnt=13,upkeep_interval_ms=30000,ssl_verifypeer=1,ssl_verifyhost=2]
[2025-03-26 19:02:48] [TRACE]   [OmnipathR] Downloaded 9.5 Kb in 0.241341s from omnipathdb.org (39.3 Kb/s); Redirect: 0s, DNS look up: 0.001546s, Connection: 0.002363s, Pretransfer: 0.161945s, First byte at: 0.241174s
[2025-03-26 19:02:48] [INFO]    [OmnipathR] Successfully retrieved: `https://omnipathdb.org/interactions?genesymbols=yes&resources=CollecTRI&datasets=tf_mirna&organisms=9606&fields=evidences,sources,references,curation_effort&license=academic`
[2025-03-26 19:02:48] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-03-26 19:02:48] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-03-26 19:02:48] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-03-26 19:02:48] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-03-26 19:02:48] [INFO]    [OmnipathR] Cache item `f7d34500401ba98803b7d2b26c48f64cee1eea1b` version 1: status changed from `unknown` to `started`.
[2025-03-26 19:02:48] [TRACE]   [OmnipathR] Exporting object to RDS: `/Users/biocbuild/Library/Caches/OmnipathR/f7d34500401ba98803b7d2b26c48f64cee1eea1b-1.rds`.
[2025-03-26 19:02:48] [TRACE]   [OmnipathR] Exported RDS to `/Users/biocbuild/Library/Caches/OmnipathR/f7d34500401ba98803b7d2b26c48f64cee1eea1b-1.rds`.
[2025-03-26 19:02:48] [INFO]    [OmnipathR] Download ready [key=f7d34500401ba98803b7d2b26c48f64cee1eea1b, version=1]
[2025-03-26 19:02:48] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-03-26 19:02:48] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-03-26 19:02:48] [INFO]    [OmnipathR] Cache item `f7d34500401ba98803b7d2b26c48f64cee1eea1b` version 1: status changed from `started` to `ready`.
[2025-03-26 19:02:48] [TRACE]   [OmnipathR] Converting JSON column `evidences` to list.
[2025-03-26 19:02:48] [TRACE]   [OmnipathR] Restricting interaction records to datasets: tf_mirna; and resources: CollecTRI
[2025-03-26 19:02:48] [TRACE]   [OmnipathR] Filtering evidence columns: positive, negative, directed, undirected; to datasets: tf_mirna; and resources: CollecTRI; excluding resources: none
[2025-03-26 19:02:49] [SUCCESS] [OmnipathR] Downloaded 232 interactions.
[2025-03-26 19:02:49] [TRACE]   [OmnipathR] Processing args for OmniPath query
[2025-03-26 19:02:49] [TRACE]   [OmnipathR] Arguments for OmniPath query: [loops=TRUE,organisms=9606,genesymbols=TRUE,query_type=interactions,datasets=collectri]
[2025-03-26 19:02:49] [TRACE]   [OmnipathR] Organism(s): 9606
[2025-03-26 19:02:49] [TRACE]   [OmnipathR] Orthology targets: 
[2025-03-26 19:02:49] [TRACE]   [OmnipathR] Looking up in cache: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=collectri&organisms=9606&fields=sources,references,curation_effort&loops=yes&license=academic`
[2025-03-26 19:02:49] [TRACE]   [OmnipathR] Loaded data from RDS `/Users/biocbuild/Library/Caches/OmnipathR/b10176737ba43d460b13709623189f3911123779-1.rds`.
[2025-03-26 19:02:49] [INFO]    [OmnipathR] Loaded from cache: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=collectri&organisms=9606&fields=sources,references,curation_effort&loops=yes&license=academic`
[2025-03-26 19:02:50] [SUCCESS] [OmnipathR] Loaded 64958 interactions from cache.
[2025-03-26 19:02:50] [TRACE]   [OmnipathR] Processing args for OmniPath query
[2025-03-26 19:02:50] [TRACE]   [OmnipathR] Arguments for OmniPath query: [genesymbols=TRUE,resources=CollecTRI,strict_evidences=TRUE,query_type=interactions,datasets=tf_mirna]
[2025-03-26 19:02:50] [TRACE]   [OmnipathR] Organism(s): 9606
[2025-03-26 19:02:50] [TRACE]   [OmnipathR] Orthology targets: 
[2025-03-26 19:02:50] [TRACE]   [OmnipathR] Reading JSON from `https://omnipathdb.org/resources` (encoding: UTF-8).
[2025-03-26 19:02:50] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-03-26 19:02:50] [TRACE]   [OmnipathR] Looking up in cache: `https://omnipathdb.org/interactions?genesymbols=yes&resources=CollecTRI&datasets=tf_mirna&organisms=9606&fields=evidences,sources,references,curation_effort&license=academic`
[2025-03-26 19:02:50] [TRACE]   [OmnipathR] Loaded data from RDS `/Users/biocbuild/Library/Caches/OmnipathR/f7d34500401ba98803b7d2b26c48f64cee1eea1b-1.rds`.
[2025-03-26 19:02:50] [INFO]    [OmnipathR] Loaded from cache: `https://omnipathdb.org/interactions?genesymbols=yes&resources=CollecTRI&datasets=tf_mirna&organisms=9606&fields=evidences,sources,references,curation_effort&license=academic`
[2025-03-26 19:02:50] [TRACE]   [OmnipathR] Converting JSON column `evidences` to list.
[2025-03-26 19:02:50] [TRACE]   [OmnipathR] Restricting interaction records to datasets: tf_mirna; and resources: CollecTRI
[2025-03-26 19:02:50] [TRACE]   [OmnipathR] Filtering evidence columns: positive, negative, directed, undirected; to datasets: tf_mirna; and resources: CollecTRI; excluding resources: none
[2025-03-26 19:02:50] [SUCCESS] [OmnipathR] Loaded 232 interactions from cache.

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Attaching package: 'dplyr'

The following object is masked from 'package:testthat':

    matches

The following objects are masked from 'package:stats':

    filter, lag

The following objects are masked from 'package:base':

    intersect, setdiff, setequal, union

[ FAIL 1 | WARN 9 | SKIP 0 | PASS 34 ]

══ Failed tests ════════════════════════════════════════════════════════════════
── Failure ('test-statistic-fgsea.R:26:3'): test run_fgsea ─────────────────────
`res_1` (`actual`) not equal to `exp_1` (`expected`).

actual vs expected
                      p_value
  actual[1, ]     0.075479709
  actual[2, ]     0.075479709
- actual[3, ]     0.511687342
+ expected[3, ]   0.548454870
- actual[4, ]     0.511687342
+ expected[4, ]   0.548454870
  actual[5, ]     0.010000000
  actual[6, ]     0.010000000
  actual[7, ]     0.076411558

actual vs expected
                      p_value
  actual[12, ]    0.010000000
  actual[13, ]    0.114238030
  actual[14, ]    0.114238030
- actual[15, ]    0.510665738
+ expected[15, ]  0.522337972
- actual[16, ]    0.510665738
+ expected[16, ]  0.522337972
  actual[17, ]    0.010000000
  actual[18, ]    0.010000000
  actual[19, ]    0.004682543
  actual[20, ]    0.004682543
- actual[21, ]    0.219233595
+ expected[21, ]  0.294730294
and 10 more ...

actual vs expected
                      p_value
  actual[34, ]    1.000000000
  actual[35, ]    0.010000000
  actual[36, ]    0.010000000
- actual[37, ]    0.091542106
+ expected[37, ]  0.103646587
- actual[38, ]    0.091542106
+ expected[38, ]  0.103646587
  actual[39, ]    0.592371428
  actual[40, ]    0.592371428
  actual[41, ]    0.010000000

actual vs expected
                      p_value
  actual[52, ]    0.976649086
  actual[53, ]    0.010000000
  actual[54, ]    0.010000000
- actual[55, ]    0.066624941
+ expected[55, ]  0.076411558
- actual[56, ]    0.066624941
+ expected[56, ]  0.076411558
  actual[57, ]    0.592371428
  actual[58, ]    0.592371428
  actual[59, ]    0.010000000
  actual[60, ]    0.010000000
- actual[61, ]    0.111211902
+ expected[61, ]  0.108185775
and 4 more ...

actual vs expected
                      p_value
  actual[70, ]    1.000000000
  actual[71, ]    0.010000000
  actual[72, ]    0.010000000
- actual[73, ]    0.256981914
+ expected[73, ]  0.469812943
- actual[74, ]    0.256981914
+ expected[74, ]  0.469812943
- actual[75, ]    0.133907888
+ expected[75, ]  0.132394821
- actual[76, ]    0.133907888
+ expected[76, ]  0.132394821
  actual[77, ]    0.123204721
  actual[78, ]    0.123204721
- actual[79, ]    0.146641013
+ expected[79, ]  0.207618744
and 4 more ...

actual vs expected
                      p_value
  actual[88, ]    0.177906190
  actual[89, ]    0.154281338
  actual[90, ]    0.154281338
- actual[91, ]    0.434796297
+ expected[91, ]  0.487321278
- actual[92, ]    0.434796297
+ expected[92, ]  0.487321278
  actual[93, ]    0.009411332
  actual[94, ]    0.009411332
  actual[95, ]    0.005020222
  actual[96, ]    0.005020222
- actual[97, ]    0.294730294
+ expected[97, ]  0.493157392
and 16 more ...

actual vs expected
                      p_value
  actual[118, ]   0.126342554
  actual[119, ]   0.111593916
  actual[120, ]   0.111593916
- actual[121, ]   0.991185346
+ expected[121, ] 1.000000000
- actual[122, ]   0.991185346
+ expected[122, ] 1.000000000
- actual[123, ]   0.123316421
+ expected[123, ] 0.126342554
- actual[124, ]   0.123316421
+ expected[124, ] 0.126342554
  actual[125, ]   0.155922629
  actual[126, ]   0.155922629
  actual[127, ]   0.592371428

actual vs expected
                      p_value
  actual[132, ]   0.124515409
  actual[133, ]   0.592371428
  actual[134, ]   0.592371428
- actual[135, ]   0.174865133
+ expected[135, ] 0.183988307
- actual[136, ]   0.174865133
+ expected[136, ] 0.183988307
  actual[137, ]   0.198360798
  actual[138, ]   0.198360798
  actual[139, ]   0.592371428

  `actual$p_value[1:7]`: 0.075 0.075 0.512 0.512 0.010 0.010 0.076
`expected$p_value[1:7]`: 0.075 0.075 0.548 0.548 0.010 0.010 0.076

     actual$p_value | expected$p_value                
[12] 0.010          | 0.010            [12]           
[13] 0.114          | 0.114            [13]           
[14] 0.114          | 0.114            [14]           
[15] 0.511          - 0.522            [15]           
[16] 0.511          - 0.522            [16]           
[17] 0.010          | 0.010            [17]           
[18] 0.010          | 0.010            [18]           
[19] 0.005          | 0.005            [19]           
[20] 0.005          | 0.005            [20]           
[21] 0.219          - 0.295            [21]           
 ... ...              ...              and 10 more ...

  `actual$p_value[34:41]`: 1.000 0.010 0.010 0.092 0.092 0.592 0.592 0.010
`expected$p_value[34:41]`: 1.000 0.010 0.010 0.104 0.104 0.592 0.592 0.010

     actual$p_value | expected$p_value               
[52] 0.977          | 0.977            [52]          
[53] 0.010          | 0.010            [53]          
[54] 0.010          | 0.010            [54]          
[55] 0.067          - 0.076            [55]          
[56] 0.067          - 0.076            [56]          
[57] 0.592          | 0.592            [57]          
[58] 0.592          | 0.592            [58]          
[59] 0.010          | 0.010            [59]          
[60] 0.010          | 0.010            [60]          
[61] 0.111          - 0.108            [61]          
 ... ...              ...              and 4 more ...

     actual$p_value | expected$p_value               
[70] 1.000          | 1.000            [70]          
[71] 0.010          | 0.010            [71]          
[72] 0.010          | 0.010            [72]          
[73] 0.257          - 0.470            [73]          
[74] 0.257          - 0.470            [74]          
[75] 0.134          - 0.132            [75]          
[76] 0.134          - 0.132            [76]          
[77] 0.123          | 0.123            [77]          
[78] 0.123          | 0.123            [78]          
[79] 0.147          - 0.208            [79]          
 ... ...              ...              and 4 more ...

     actual$p_value | expected$p_value                
[88] 0.178          | 0.178            [88]           
[89] 0.154          | 0.154            [89]           
[90] 0.154          | 0.154            [90]           
[91] 0.435          - 0.487            [91]           
[92] 0.435          - 0.487            [92]           
[93] 0.009          | 0.009            [93]           
[94] 0.009          | 0.009            [94]           
[95] 0.005          | 0.005            [95]           
[96] 0.005          | 0.005            [96]           
[97] 0.295          - 0.493            [97]           
 ... ...              ...              and 16 more ...

      actual$p_value | expected$p_value      
[118] 0.126          | 0.126            [118]
[119] 0.112          | 0.112            [119]
[120] 0.112          | 0.112            [120]
[121] 0.991          - 1.000            [121]
[122] 0.991          - 1.000            [122]
[123] 0.123          - 0.126            [123]
[124] 0.123          - 0.126            [124]
[125] 0.156          | 0.156            [125]
[126] 0.156          | 0.156            [126]
[127] 0.592          | 0.592            [127]

  `actual$p_value[132:139]`: 0.125 0.592 0.592 0.175 0.175 0.198 0.198 0.592
`expected$p_value[132:139]`: 0.125 0.592 0.592 0.184 0.184 0.198 0.198 0.592

[ FAIL 1 | WARN 9 | SKIP 0 | PASS 34 ]
Error: Test failures
Execution halted

Example timings

decoupleR.Rcheck/decoupleR-Ex.timings

nameusersystemelapsed
check_corr0.0300.0050.034
convert_f_defaults0.0080.0010.010
decouple000
dot-fit_preprocessing0.0080.0010.008
extract_sets0.0070.0000.007
filt_minsize0.0120.0010.013
get_collectri 3.149 0.39410.792
get_dorothea 7.603 0.63312.960
get_profile_of0.0000.0010.000
get_progeny 2.874 0.23510.403
get_resource0.3170.0422.322
get_toy_data0.0010.0000.001
intersect_regulons0.0080.0040.014
pipe000
pivot_wider_profile0.0000.0010.000
randomize_matrix000
rename_net0.0120.0030.017
run_aucell3.7981.7148.669
run_consensus0.8390.2441.427
run_fgsea10.171 0.71012.681
run_gsva0.9780.7432.852
run_mdt0.0860.0340.178
run_mlm0.0450.0150.082
run_ora0.2440.0750.395
run_udt0.1220.0370.171
run_ulm0.0310.0150.049
run_viper0.3490.2670.980
run_wmean0.2310.0570.361
run_wsum0.2320.0420.318
show_methods0.0190.0050.036
show_resources0.0190.0030.539
tidyeval0.0000.0010.000