1.34.1 (2018-06-28) + Updating! Extend aFold to paired samples 1.32.2 (2017-12-18) + Updating! Refine qtotal (R funtion: qtotalNormalized) 1.30.1 (2017-07-18) + Updating! Adapt aFold model for complex design with linear model (R funtion: ABSSeqlm) 1.30.1 (2017-06-02) + Updating! Introduce a new approach for normalization as qtotal (R funtion: qtotalNormalized) + aFold now moderates fold changes upon overall dispersion and gene-specific dispersion 1.11.0 (2017-02-14) + Updating! Adding new method: aFold to call DE via fold-change 1.6.0 (2016-02-29) + Updating! Enable the paired comparison by seting up 'paired' parameter in 'ABSDataSet' object 1.5.1 (2015-08-24) + This is the second version of ABSSeq. 1) Use NB distribution insead of GP to model the counts difference between conditions 2) Introduce an efficient outlier detection method: moderated MAD 3) Introduce penalty for dispersion estimation 4) Provide moderation of log2 fold-change at expression level and gene-specific dispersion