\name{SingleSnpTests-class} \docType{class} \alias{SingleSnpTests-class} \alias{[,SingleSnpTests,ANY,missing,missing-method} \alias{chi.squared,SingleSnpTests,numeric-method} \alias{names,SingleSnpTests-method} \alias{p.value,SingleSnpTests,numeric-method} \alias{sample.size,SingleSnpTests-method} \alias{effective.sample.size,SingleSnpTests-method} \alias{show,SingleSnpTests-method} \alias{summary,SingleSnpTests-method} \alias{coerce,SingleSnpTests,data.frame-method} \alias{SingleSnpTestsScore-class} \alias{[,SingleSnpTestsScore,ANY,missing,missing-method} \alias{effect.sign,SingleSnpTestsScore,missing-method} \alias{pool2,SingleSnpTestsScore,SingleSnpTestsScore,logical-method} \alias{switch.alleles,SingleSnpTestsScore,ANY-method} \title{Classes "SingleSnpTests" and "SingleSnpTestsScore"} \description{These are classes to hold the objects created by \code{\link{single.snp.tests}} and provide methods for extracting key elements. The class \code{"SingleSnpTestsScore"} extends class \code{"SingleSnpTests"} to include the score and score variance statistics in order to provide methods for pooling results from several studies or parts of a study } \section{Objects from the Class}{ Objects can be created by calls of the form \code{new("SingleSnpTests", ...)} and \code{new("SingleSnpTestsScore", ...)} but, more usually, will be created by calls to \code{\link{single.snp.tests}} } \section{Slots}{ \describe{ \item{\code{snp.names}:}{The names of the SNPs tested, as they appear as column names in the original \code{SnpMatrix}} \item{\code{chisq}:}{A two-column matrix holding the 1 and 2 df association tests} \item{\code{N}:}{The numbers of observations included in each test} \item{\code{N.r2}:}{For tests on imputed SNPs, the product of \code{N} and the imputation \eqn{r^2}. Otherwise a zero-length object} \item{\code{U}:}{(class \code{"SingleSnpTestsScore"}) Score statistics} \item{\code{V}:}{(class \code{"SingleSnpTestsScore"}) Score variances} } } \section{Methods}{ \describe{ \item{[]}{\code{signature(x = "SingleSnpTests", i = "ANY")}: Subsetting operator} \item{[]}{\code{signature(x = "SingleSnpTestsScore", i = "ANY")}: Subsetting operator} \item{chi.squared}{\code{signature(x = "SingleSnpTests", df = "numeric")}: Extract 1- and 2-df chi-squared test values} \item{effect.sign}{\code{signature(x = "SingleSnpTestsScore", simplify = "missing")}: Extract signs of associations tested by the 1df tests} \item{names}{\code{signature(x="SingleSnpTests")}: Extract names of test values (\code{snp.names} slot)} \item{p.value}{\code{signature(x = "SingleSnpTests", df = "numeric")}: Evaluate 1- and 2-df test p-values} \item{show}{\code{signature(object = "SingleSnpTests")}: List all tests and p-values} \item{coerce}{\code{signature(from = "SingleSnpTests", to = "data.frame")}: Conversion to data frame class} \item{sample.size}{\code{signature(object = "SingleSnpTests")}: Extract sample sizes for tests} \item{effective.sample.size}{\code{signature(object = "SingleSnpTests")}: Extract effective sample sizes for tests. For imputed tests, these are the real sample sizes multiplied by the corresponding R-squared values for imputation} \item{summary}{\code{signature(object = "SingleSnpTests")}: Summarize all tests and p-values} \item{pool2}{\code{signature(x = "SingleSnpTestsScore", y = "SingleSnpTestsScore", score = "logical")}: Combine two sets of test results. Used recursively by {\code{\link{pool}}}} \item{switch.alleles}{\code{signature(x = "SingleSnpTestsScore", snps = "ANY")}: Emulate, in the score vector and its (co)variances, the effect of switching of the alleles for the specified tests} } } \author{David Clayton \email{david.clayton@cimr.cam.ac.uk}} \seealso{ \code{\link{single.snp.tests}}, \code{\link{pool}} } \examples{ showClass("SingleSnpTests") showClass("SingleSnpTestsScore") } \keyword{classes}