\name{summarizeFarmsExact} \alias{summarizeFarmsExact} \title{Summarization Laplacian approach with exact computation} \usage{ summarizeFarmsExact(probes, mu = 0, weight = 0.5, weightZ = 1, weightProbes = TRUE, cyc = c(10, 10), tol = 1e-05, weightType = "mean", centering = "median", rescale = FALSE, backscaleComputation = FALSE, maxIntensity = TRUE, refIdx, ...) } \arguments{ \item{probes}{A matrix with numeric values.} \item{mu}{Hyperparameter value which allows to quantify different aspects of potential prior knowledge. Values near zero assumes that most positions do not contain a signal, and introduces a bias for loading matrix elements near zero. Default value is 0.} \item{weight}{Hyperparameter value which determines the influence of the Gaussian prior of the loadings} \item{weightZ}{Hyperparameter value which determines how strong the Laplace prior of the factor should be at 0.} \item{weightProbes}{States if the probes should be weighted.} \item{cyc}{Number of cycles. If the length is two, it is assumed, that a minimum and a maximum number of cycles is given. If the length is one, the value is interpreted as the exact number of cycles to be executed (minimum == maximum).} \item{tol}{States the termination tolerance if cyc[1]!=cyc[2]. Default is 0.00001.} \item{weightType}{Flag, that is used to summarize the loading matrix.} \item{centering}{States how the data is centered. Default is median.} \item{rescale}{Rescales the Moments.} \item{backscaleComputation}{New estimation of z values after backscaling.} \item{maxIntensity}{Use of the mode values for building expression values, if set to TRUE.} \item{refIdx}{index or indices which are used for computation of the centering} \item{...}{Further parameters for expert users.} } \value{ A list including: the found parameters: lambda0, lambda1, Psi the estimated factors: z (expectation), maxZ (maximum) p: log-likelihood of the data given the found lambda0, lambda1, Psi (not the posterior likelihood that is optimized) varzx: variances of the hidden variables given the data KL: Kullback Leibler divergences between between posterior and prior distribution of the hidden variables IC: Information Content considering the hidden variables and data ICtransform: transformed Information Content Case: Case for computation of a sample point (non-exception, special exception) L1median: Median of the lambda vector components intensity: back-computed summarized probeset values with mean correction L_z: back-computed summarized probeset values without mean correction rawCN: transformed values of L_z SNR: some additional signal to noise ratio value } \description{ This function implements an exact Laplace FARMS algorithm. Users should be aware, that a change of weight in comparison to the default parameter might also entail a need to change of eps1 and eps2. Unexperienced users should not change weightZ, since a change in weightZ is also connected to weight, eps1 and eps2. } \examples{ x <- matrix(rnorm(100, 11), 20, 5) summarizeFarmsExact(x) } \author{ Andreas Mayr \email{mayr@bioinf.jku.at} and Djork-Arne Clevert \email{okko@clevert.de} and Andreas Mitterecker \email{mitterecker@bioinf.jku.at} }