\name{CoHyperGResult-class} \docType{class} \alias{CoHyperGResult-class} \alias{summary,CoHyperGResult-method} \alias{geneCounts,CoHyperGResult-method} \alias{pvalues,CoHyperGResult-method} \alias{oddsRatios,CoHyperGResult-method} \alias{universeCounts,CoHyperGResult-method} \alias{expectedCounts,CoHyperGResult-method} \title{Class "CoHyperGResult"} \description{ This class represents the results of a test for over-representation of genes in a selected gene set based among protein complexes upon the Hypergeometric distribution. } \section{Objects from the Class}{ Objects is created by calls to the funtion hyperGTest. } \section{Slots}{ \describe{ \item{\code{pvalues}:}{\code{"numeric"} vector: the ordered p-values for each category term tested.} \item{\code{geneCounts}:}{\code{"integer"} vector: for each category term tested, the number of genes from the gene set that are annotated at the term.} \item{\code{universeCounts}:}{\code{"integer"} vector: for each category term tested, the number of genes from the gene universe that are annotated at the term.} \item{\code{catToGeneId}:}{Object of class \code{"list"}. The names of the list are category IDs. Each element is a vector of gene IDs annotated at the given category ID and in the specified gene universe.} \item{\code{annotation}:}{A string giving the name of the chip annotation data package used.} \item{\code{geneIds}:}{Object of class \code{"ANY"}: the input vector of gene identifiers intersected with the universe of gene identifiers used in the computation. The class of this slot is specified as \code{"ANY"} because gene IDs may be integer or character vectors depending on the annotation package.} \item{\code{testName}:}{A string identifying the testing method used.} \item{\code{pvalueCutoff}:}{Numeric value used a a p-value cutoff. Used by the \code{show} method to count number of significant terms. } } } \section{Extends}{ Class \code{"HyperGResultBase"}, directly. } \section{Methods}{ \describe{ \item{geneCounts}{\code{signature(r = "CoHyperGResult")}: return an \code{"numeric"} vector: for each category term tested, the number of genes from the gene set that are annotated at the term.} \item{pvalues}{\code{signature(r = "HyperGResult")}: return a \code{"numeric"} vector: the ordered p-values for each category term tested.} \item{oddsRatios}{\code{signature(r = "HyperGResult")}: return a \code{"numeric"} vector: the odds ratio for each category term tested.} \item{expectedCounts}{\code{signature(r = "HyperGResult")}: return a \code{"numeric"} vector: the expected number of genes for each GO term tested.} \item{universeCounts}{\code{signature(r = "HyperGResult")}: return an \code{"numeric"} vector: for each category term tested, the number of genes from the gene universe that are annotated at the term.} \item{geneIdUniverse}{\code{signature(r = "CoHyperGResult")}: return a list named by the protein Complexes. Each element of the list is a vector of gene identifiers (from the gene universe) annotated at the corresponding protein complex.} \item{summary}{\code{signature(r = "CoHyperGResult")}: Returns a \code{data.frame} summarizing the test result. Optional arguments \code{pvalue} and \code{categorySize} allow specification of minimum p-value and cateogyrSize, respectively. Optional argument \code{htmlLinks} is a logical value indicating whether to add HTML links (useful in conjunction with xtables print method with \code{type} set to \code{"html"}).} } } \author{S. Falcon and N. LeMeur} \seealso{ \code{\link[category]{HyperGResultBase-class}} } \examples{ data(DudleyPhenoM) data(ScISIC) ## Select genes sensitive to paraquat DudleyPhenoL <- apply(DudleyPhenoM,2,function(x) names(which(x==1))) paraquat <- DudleyPhenoL[["Paraq"]] ## Apply a hypergeometric test params <- new("CoHyperGParams", geneIds=paraquat, universeGeneIds=rownames(ScISIC), annotation="org.Sc.sgd.db", categoryName="ScISIC", pvalueCutoff=0.01, testDirection="over") paraquat.complex <- hyperGTest(params) ## access the p-values pvalues(paraquat.complex)[1:5] ## Display a summary of the results summary(paraquat.complex)[,1:4] } \keyword{classes}