\name{runDEGraph} \alias{runDEGraph} \docType{data} \title{ Run topological analysis on expression dataset using DEGraph package. See \code{\link[DEGraph:testOneGraph]{testOneGraph}}. } \description{ DEGraph implements recent hypothesis testing methods which directly assess whether a particular gene network is differentially expressed between two conditions. See \code{\link[DEGraph:testOneGraph]{testOneGraph}} for more details. } \usage{ runDEGraph(pathway, expr, classes) } \arguments{ \item{pathway}{ One of the pathways contained in \link{biocarta}, \link{kegg},\link{nci} or \link{reactome}. } \item{expr}{ A \code{matrix} (size: number \code{p} of genes x number \code{n} of samples) of gene expression. } \item{classes}{ A \code{vector} (length: \code{n}) of class assignments. } } \details{ The expression data and the pathway have to be annotated in the same set of identifiers. } \references{ L. Jacob, P. Neuvial, and S. Dudoit. Gains in power from structured two-sample tests of means on graphs. Technical Report arXiv:q-bio/1009.5173v1, arXiv, 2010. } \examples{ if (require(DEGraph)) { data("Loi2008_DEGraphVignette") p <- convertIdentifiers(biocarta[["actions of nitric oxide in the heart"]], "entrez") runDEGraph(p, exprLoi2008, classLoi2008) } } \keyword{topology} \keyword{analysis} \keyword{DEGraph}