\name{combineMotifs} \docType{methods} \alias{combineMotifs} \alias{combineMotifs-method} \alias{combineMotifs,motiv,list-method} \alias{combineMotifs,motiv,filters-method} \title{Combine Motifs } \description{ This function combines motifs according to a set of filters. } \usage{ \S4method{combineMotifs}{motiv,filters}(x, y, name=NULL,exact=TRUE,verbose=TRUE) } \arguments{ \item{x}{An object of class \code{motiv}.} \item{y}{A filter or a set of filter.} \item{name}{Name(s) to be given for similar motifs.} \item{verbose}{If \code{FALSE}, no output will be print.} \item{exact}{If \code{TRUE}, search only for perfect name match.} } \details{ This function is used to consider some motifs as a unique motif or \code{similar} motifs. Many \code{filters} could be pass in argument separated by coma. They will be considered independently (coma is considered as \code{OR}). If a name or a vector of name is provided, it will be used to assign new name for similar motif to the corresponding filter. Else, a generic name is used. } \value{A \code{motiv} object.} \author{Eloi Mercier <\email{emercier@chibi.ubc.ca}>} \seealso{ \code{setFilter} , \code{filter}, \code{split} } \examples{ #####Database and Scores##### path <- system.file(package="MotIV") jaspar <- readPWMfile(paste(path,"/extdata/jaspar2010.txt",sep="")) jaspar.scores <- readDBScores(paste(path,"/extdata/jaspar2010_PCC_SWU.scores",sep="")) #####Input##### data(FOXA1_rGADEM) motifs <- getPWM(gadem) motifs.trimed <- trimPWMedge(motifs, threshold=1) #####Analysis##### foxa1.analysis.jaspar <- motifMatch(inputPWM=motifs,align="SWU",cc="PCC",database=jaspar,DBscores=jaspar.scores,top=5) summary(foxa1.analysis.jaspar ) #####Filters##### f.foxa1<-setFilter(name="", tfname="FOXA1", top=3, evalueMax=10^-5) f.ap1 <- setFilter (tfname="AP1", top=3) f.foxa1.ap1 <- f.foxa1 | f.ap1 foxa1.filter <- filter(foxa1.analysis.jaspar, f.foxa1.ap1, exact=FALSE, verbose=TRUE) foxa1.filter.combine <- combineMotifs(foxa1.filter, c(f.foxa1, f.ap1), exact=FALSE, name=c("FOXA1", "AP1"), verbose=TRUE) } \keyword{methods}