fig:score-heatmap-grun fig:score-heatmap-grun-donor fig:score-dist-grun fig:grun-beta-heat fig:grun-beta-heat-all fig:grun-epsilon-heat fig:grun-label-clusters fig:heat-combined fig:delta-combined fig:pbmc-mono-heat fig:heat-harmony fig:unref-pancreas-score-heatmap fig:unref-pancreas-delta-dist fig:unref-pancreas-marker-heat fig:unref-pancreas-label-clusters fig:unref-pancreas-label-tsne fig:unref-brain-score-heatmap fig:unref-brain-delta-dist fig:unref-brain-marker-heat fig:unref-brain-label-clusters fig:unref-brain-label-tsne introduction motivation method-description quick-start where-to-get-help classic-mode overview annotating-the-test-dataset interaction-with-quality-control choices-of-assay-data reference-choice sc-mode overview-1 annotation-with-test-based-marker-detection defining-custom-markers pseudo-bulk-aggregation annotation-diagnostics overview-2 based-on-the-scores-within-cells based-on-the-deltas-across-cells based-on-marker-gene-expression comparing-to-unsupervised-clustering using-multiple-references overview-3 using-reference-specific-labels comparing-scores-across-references combining-inferences-from-individual-references combined-diagnostics using-harmonized-labels sharing-information-during-marker-detection manual-label-harmonization exploiting-the-cell-ontology motivation-1 basic-manipulation adjusting-resolution advanced-options preconstructed-indices parallelization approximate-algorithms cluster-level-annotation pancreas-case-study loading-the-data applying-the-annotation diagnostics comparison-to-clusters cross-annotating-mouse-brains loading-the-data-1 applying-the-annotation-1 diagnostics-1 comparison-to-clusters-1 contributors bibliography