## ---- eval = FALSE------------------------------------------------------- # if (!requireNamespace("BiocManager", quietly=TRUE)) # install.packages("BiocManager") # BiocManager::install("TCGAbiolinksGUI", dependencies = TRUE) ## ---- eval = FALSE------------------------------------------------------- # if (!requireNamespace("BiocManager", quietly=TRUE)) # install.packages("BiocManager") # deps <- c("devtools") # BiocManager::install("devtools", dependencies = TRUE) # devtools::install_github("BioinformaticsFMRP/TCGAbiolinksGUI.data",ref = "R_3.4") # devtools::install_github("BioinformaticsFMRP/TCGAbiolinksGUI") ## ---- eval = FALSE------------------------------------------------------- # library(TCGAbiolinksGUI) # TCGAbiolinksGUI() ## ----table2, echo=FALSE, message=FALSE, warnings=FALSE, results='asis'---- tabl <- " | Menu | Sub-menu | Button | Data input | Example Input | |---------------------------------|-----------------------------------|------------------------------------|-------------------------------------------------------------------------------------------|----------------------------| | Clinical analysis | Survival Plot | Select file | A table with at least the following columns: days_to_death, days_to_last_followup and one column with a group | [Example input](https://drive.google.com/open?id=1pWYEZsojafQMav8v3MrRVTIkFKyCSGfY) | | Epigenetic analysis | Differential methylation analysis | Select data (.rda) | A summarizedExperiment object | [Example input](https://github.com/BioinformaticsFMRP/Bioc2017.TCGAbiolinks.ELMER/raw/master/data/lusc.met.rda) | | Epigenetic analysis | Volcano Plot | Select results | A CSV file with the following pattern: DMR_results_GroupCol_group1_group2_pcut_0.01_meancut_0.5.csv (Where GroupCol, group1, group2 are the names of the columns selected in the DMR steps. | [Example input](https://drive.google.com/open?id=1lUS2hEJHP4PC6vfeO-ckLbLe-6xx0ddQ) in which diffmean.group1.group2= mean group 2 - mean group 1 | | Epigenetic analysis | Heatmap plot | Select file | A summarizedExperiment object | [Example input](https://github.com/BioinformaticsFMRP/Bioc2017.TCGAbiolinks.ELMER/raw/master/data/lusc.met.rda) | | Epigenetic analysis | Heatmap plot | Select results | Same as Epigenetic analysis >Volcano Plot > Select results || | Epigenetic analysis | Mean DNA methylation | Select file | A summarizedExperiment object | [Example input](https://github.com/BioinformaticsFMRP/Bioc2017.TCGAbiolinks.ELMER/raw/master/data/lusc.met.rda) | | Transcriptomic Analysis | Volcano Plot | Select results | A CSV file with the following pattern: DEA_results_GroupCol_group1_group2_pcut_0.01_logFC.cut_2.csv (Where GroupCol, group1, group2 are the names of the columns selected in the DEA steps. | [Example input](https://drive.google.com/open?id=1lUS2hEJHP4PC6vfeO-ckLbLe-6xx0ddQ) ) in which logFC= loag( group 2/ group1)| | Transcriptomic Analysis | Heatmap plot | Select file | A summarizedExperiment object | [Example input](https://github.com/BioinformaticsFMRP/Bioc2017.TCGAbiolinks.ELMER/raw/master/data/lusc.met.rda)| | Transcriptomic Analysis | Heatmap plot | Select results | A CSV file with results of the DMR or DEA | [Example input](https://drive.google.com/open?id=1lUS2hEJHP4PC6vfeO-ckLbLe-6xx0ddQ) in which diffmean.group1.group2= mean group 2 - mean group 1 | | Transcriptomic Analysis | OncoPrint plot | Select MAF file | A MAF file (columns needed: Hugo_Symbol,Tumor_Sample_Barcode,Variant_Type) | Deafult GDC MAF files || | Transcriptomic Analysis | OncoPrint plot | Select Annotation file | A file with at least the following columns: bcr_patient_barcode | [Example input](https://drive.google.com/open?id=1pWYEZsojafQMav8v3MrRVTIkFKyCSGfY| | Integrative analysis | Starburst plot | DMR result | A CSV file with the following pattern: DMR_results_GroupCol_group1_group2_pcut_0.01_meancut_0.55.csv (Where GroupCol, group1, group2 are the names of the columns selected in the DMR steps. | [Example input](https://drive.google.com/open?id=1lUS2hEJHP4PC6vfeO-ckLbLe-6xx0ddQ) in which diffmean.group1.group2= mean group 2 - mean group 1 | | Integrative analysis | Starburst plot | DEA result | A CSV file with the following pattern: DEA_results_GroupCol_group1_group2_pcut_0.01_FC.cut_2.csv (Where GroupCol, group1, group2 are the names of the columns selected in the DEA steps.| [Example input](https://drive.google.com/open?id=1lUS2hEJHP4PC6vfeO-ckLbLe-6xx0ddQ) ) in which logFC= loag( group 2/ group1)| | Integrative analysis | ELMER | Create MAE > Select DNA methylation object | An rda file with a summarized Experiment object | [Example input](https://github.com/BioinformaticsFMRP/Bioc2017.TCGAbiolinks.ELMER/raw/master/data/lusc.met.rda) | | Integrative analysis | ELMER | Create MAE > Select expression object | An rda file with the RNAseq data frame | [Example input](https://github.com/BioinformaticsFMRP/Bioc2017.TCGAbiolinks.ELMER/raw/master/data/lusc.exp.rda) | | Integrative analysis | ELMER | Select MAE | An rda file with a MAE object | [Example input](https://drive.google.com/open?id=17ovzQ-czPfsAjZ1JJLjLPvdm1aN2_C8r)| | Integrative analysis | ELMER | Select results | An rda file with the results of the ELMER analysis | [Example input](https://drive.google.com/open?id=1OP8BKoFfkH5knTVjvAHq2lLjfmpub9ei)| " cat(tabl)