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Installing ensemblVEP 
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To use ensemblVEP, the Ensembl Variant Effect Predictor (VEP)
software must be installed.

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Download and Install Ensembl VEP
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Follow the download and installation instructions on this page:
http://uswest.ensembl.org/info/docs/tools/vep/script/index.html

On Windows you may need to install the perl modules 
perl-DBD-mysql and perl-DBI if you do not have them.
All of this is documented on the Ensembl VEP web page. 

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Confirm installation
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Check that variant_effect_predictor.pl is executable and in
your path. This may involve modifying .bashrc and / or .profile
files.

On Unix and Mac:
  variant_effect_predictor.pl

On Windows:
  perl variant_effect_predictor.pl