Changes in version 1.3.4: o BiGGR publication is now available at PLoS ONE! Use citation("BiGGR") to see how to correctly cite BiGGR. Changes in version 1.1.5: o Three new functions o rmvSpliceVariant: remove splicing variants from entrez gene ids. o gprMapping: maps gene expression values based on GPR rules as found in ReconX database. GPR rules are interpreted based on summary statistics. o gprMappingAvg: maps gene expression values with GPR rules based on averages o Recon2: Updated new version of Recon2 from www.humanmetabolism.org Changes in version 1.1.4: o Updated vignette. Equality constraints on GABA shunt and pentose phosphate pathway fluxes are now used in FBA and ensemble simulations. Changes in version 1.1.3: o Updated vignette and bibtex file. FBA and ensemble sampling are now done with integration of brain metabolite uptake measurement data. o Added new function 'sampleFluxEnsemble' which can be used to generate a posterior distribution of flux vectors with respect to measurement error in certain fluxes. An example of 'sampleFluxEnsemble' has been added to the package vignette. o Added LIM model file 'Glycolysis_TCA.LIM' to the examples directory. This file contains the model which is build in the examples. o Fixed warnings in functions buildSBMLFromReactionIDs and createLIMFromSBML to seperate missing identifiers with a comma. Changes in version 0.99.3: o Initial release of BiGGR in Bioconductor. Package was formerly available on CRAN (http://cran.r-project.org/src/contrib/Archive/BiGGR/).