Changes in version 1.4.0 * Added isoformProportions(), which can be run after scaleInfReps() and optionally after filtering out transcripts using labelKeep(). Running swish() after isoformProportions() will produce differential transcript usage (DTU) results, instead of differential transcript expression (DTE) results. Example in vignette. + Default number of permutations increased from 30 to 100. It was observed that there was too much fluctuation in the DE called set for nperms=30 across different seeds, and setting to 100 helped to stabilize results across seeds, without increasing running time too much. For further reduced dependence on the seed, even higher values of nperms (e.g. 200, 300) can be used. Changes in version 1.3.8 * Added isoformProportions(), which can be run after scaleInfReps() and optionally after filtering out transcripts using labelKeep(). Running swish() after isoformProportions() will produce differential transcript usage (DTU) results, instead of differential transcript expression (DTE) results. Example in vignette. Changes in version 1.3.4 + Default number of permutations increased from 30 to 100. It was observed that there was too much fluctuation in the DE called set for nperms=30 across different seeds, and setting to 100 helped to stabilize results across seeds, without increasing running time too much. For further reduced dependence on the seed, even higher values of nperms (e.g. 200, 300) can be used. Changes in version 1.2.0 + Switching to a faster version of Swish which only computes the ranks of the data once, and then re-uses this for the permutation distribution. This bypasses the addition of uniform noise per permutation and is 10x faster. Two designs which still require re-computation of ranks per permutation are the paired analysis and the general interaction analysis. Two-group, stratified two-group, and the paired interaction analysis now default to the new fast method, but the original, slower method can be used by setting fast=0 in the call to swish(). + Adding Rcpp-based function readEDS() written by Avi Srivastava which imports the sparse counts stored in Alevin's Efficient Data Storage (EDS) format. + Changed the vignette so that it (will) use a linkedTxome, as sometime the build would break if the Bioc build machine couldn't access ftp.ebi.ac.uk. + Add 'computeInfRV' function. InfRV is not used in the Swish methods, only for visualization purposes in the Swish paper. + removed 'samr' from Imports, as it required source installation, moved to Suggests, for optional qvalue calculation Changes in version 0.99.30 + added two interaction tests, described in ?swish + incorporate qvalue package for pvalue, locfdr and qvalue + added plotMASwish() to facilitate plotting + wilcoxP is removed, and the mean is used instead Changes in version 0.99.0 + fishpond getting ready for submission to Bioc