CHANGES IN VERSION 1.2.2 ------------------------- o update the citation CHANGES IN VERSION 1.2.1 ------------------------- o work around gcc-10 CHANGES IN VERSION 1.2.0 ------------------------- o `seqAssocGLMM_SPA()` can save to a RDS file CHANGES IN VERSION 1.0.2 ------------------------- o fix an issue when there is no covariate in the formula (e.g., y ~ 1) CHANGES IN VERSION 1.0.1 ------------------------- o add a new option for the threshold of missing variant to `seqAssocGLMM_SPA()` o change the output column 'AC.alt' to 'mac' in `seqAssocGLMM_SPA()` o retry model fitting at least 10 times if matrix is singular or not positive definite, or large variance is observed CHANGES IN VERSION 1.0.0 ------------------------- o first Bioconductor release CHANGES IN VERSION 0.99.0 (10-02-2019) ------------------------- o package submitted to Bioconductor CHANGES IN VERSION 0.9.10 (08-12-2019) ------------------------- o SAIGE algorithm implementation for quantitative outcomes CHANGES IN VERSION 0.9.9 (07-24-2019) ------------------------- o add a vignette to the package o the default of random number generator changes in R: "Rounding" was the default in `RNGkind()` prior to R_3.6.0, but "Rejection" is used in R (>= v3.6.0). For reproduction of the results created by R (< v3.6.0), please use `RNGkind("Mersenne-Twister", "Inversion", "Rounding")` in R (>= v3.6.0) CHANGES IN VERSION 0.9.7 (06-08-2019) ------------------------- o seqAssocGLMM_SPA(): load balancing in parallel CHANGES IN VERSION 0.9.0 (01-07-2019) ------------------------- o first version of SAIGEgds