tce-load -i pygobject2-dev gtk2-dev libglade-dev libxml2-dev

cd pygtk-2.24.0

CC="gcc -flto -fuse-linker-plugin -mtune=generic -Os -pipe" CXX="g++ -flto -fuse-linker-plugin -mtune=generic -Os -pipe -fno-exceptions -fno-rtti" ./configure --prefix=/usr/local --disable-static --localstatedir=/var

find . -name Makefile -type f -exec sed -i 's/-g -O2//g' {} \;

make
sudo make install

The following modules will be built:

atk
pango
pangocairo
gtk with 2.24 API
gtk.glade
gtk.unixprint

Numpy support: no