### library(Biostrings) library(GenomeInfoDb) ### Download GCA_000001405.15_GRCh38_top-level.fna.gz from ### ftp://ftp.ncbi.nlm.nih.gov/genbank/genomes/Eukaryotes/vertebrates_mammals/Homo_sapiens/GRCh38 ### then uncompress with gunzip GCA_000001405.15_GRCh38_top-level.fna.gz GRCh38 <- readDNAStringSet("GCA_000001405.15_GRCh38_top-level.fna") m_data <- strsplit(names(GRCh38), "|", fixed=TRUE) fasta_headers <- matrix(unlist(m_data, use.names=FALSE), ncol=length(m_data)) GRCh38_accns <- fasta_headers[4L, ] stopifnot(!any(duplicated(GRCh38_accns))) GRCh38_accn2seqlevel <- GenomeInfoDb:::fetch_GenBankAccn2seqlevel_from_NCBI("GCF_000001405.26") stopifnot(setequal(GRCh38_accns, names(GRCh38_accn2seqlevel))) GRCh38_seqlevels <- GRCh38_accn2seqlevel[GRCh38_accns] for (i in seq_along(GRCh38)) { filename <- paste0(GRCh38_seqlevels[[i]], ".fa") cat("writing ", filename, "\n", sep="") writeXStringSet(GRCh38[i], file=filename, width=50L) }