Macarron is a workflow to systematically annotate and prioritize potentially bioactive (and often unannotated) small molecules in microbial community metabolomic datasets. Macarron prioritizes metabolic features as potentially bioactive in a phenotype/condition of interest using a combination of (a) covariance with annotated metabolites, (b) ecological properties such as abundance with respect to covarying annotated compounds, and (c) differential abundance in the phenotype/condition of interest.
If you have questions, please direct it to: Macarron Forum
Macarron requires R version 4.2.0 or higher. Install Bioconductor and then install Macarron:
if(!requireNamespace("BiocManager", quietly = TRUE))
install.packages("BiocManager")
BiocManager::install("Macarron")
Macarron can be run from the command line or as an R function. Both methods require the same
arguments, have the same options, and use the same default settings. The package includes the
wrapper Macarron()
as well as functions which perform different steps in the Macarron
framework.
Macarron requires 4 comma-separated, appropriately formatted input files. The files and their formatting constraints are described below.
If you do not have the chemical taxonomy file, you can generate this file using the annotation dataframe and Macarron utility decorate_ID
(see Advanced Topics).
By default, all files will be stored in a folder named Macarron_output inside the current working directory. The main prioritization results are stored in prioritized_metabolites_all.csv
. Another file, prioritized_metabolites_characterizable.csv
is a subset of prioritized_metabolites_all.csv
and only contains metabolic features which covary with at least one annotated metabolite.
The columns in these output files are:
Maaslin2
.Example (demo) input files can be found under inst/extdata
folder of the Macarron
source. These files were generated from the PRISM study of stool metabolomes of individuals with inflammatory bowel disease (IBD) and healthy “Control” individuals. Control and IBD are the two phenotypes in this example. Macarron will be applied to prioritize metabolic features with respect to their bioactivity in IBD. Therefore, in this example, the phenotype of interest is “IBD” and the reference phenotype is “Control”. The four input files are demo_abundances.csv
, demo_annotations.csv
, demo_metadata.csv
, and demo_taxonomy.csv
.
library(Macarron)
## Loading required package: SummarizedExperiment
## Loading required package: MatrixGenerics
## Loading required package: matrixStats
##
## Attaching package: 'MatrixGenerics'
## The following objects are masked from 'package:matrixStats':
##
## colAlls, colAnyNAs, colAnys, colAvgsPerRowSet, colCollapse,
## colCounts, colCummaxs, colCummins, colCumprods, colCumsums,
## colDiffs, colIQRDiffs, colIQRs, colLogSumExps, colMadDiffs,
## colMads, colMaxs, colMeans2, colMedians, colMins, colOrderStats,
## colProds, colQuantiles, colRanges, colRanks, colSdDiffs, colSds,
## colSums2, colTabulates, colVarDiffs, colVars, colWeightedMads,
## colWeightedMeans, colWeightedMedians, colWeightedSds,
## colWeightedVars, rowAlls, rowAnyNAs, rowAnys, rowAvgsPerColSet,
## rowCollapse, rowCounts, rowCummaxs, rowCummins, rowCumprods,
## rowCumsums, rowDiffs, rowIQRDiffs, rowIQRs, rowLogSumExps,
## rowMadDiffs, rowMads, rowMaxs, rowMeans2, rowMedians, rowMins,
## rowOrderStats, rowProds, rowQuantiles, rowRanges, rowRanks,
## rowSdDiffs, rowSds, rowSums2, rowTabulates, rowVarDiffs, rowVars,
## rowWeightedMads, rowWeightedMeans, rowWeightedMedians,
## rowWeightedSds, rowWeightedVars
## Loading required package: GenomicRanges
## Loading required package: stats4
## Loading required package: BiocGenerics
##
## Attaching package: 'BiocGenerics'
## The following objects are masked from 'package:stats':
##
## IQR, mad, sd, var, xtabs
## The following objects are masked from 'package:base':
##
## Filter, Find, Map, Position, Reduce, anyDuplicated, aperm, append,
## as.data.frame, basename, cbind, colnames, dirname, do.call,
## duplicated, eval, evalq, get, grep, grepl, intersect, is.unsorted,
## lapply, mapply, match, mget, order, paste, pmax, pmax.int, pmin,
## pmin.int, rank, rbind, rownames, sapply, setdiff, table, tapply,
## union, unique, unsplit, which.max, which.min
## Loading required package: S4Vectors
##
## Attaching package: 'S4Vectors'
## The following object is masked from 'package:utils':
##
## findMatches
## The following objects are masked from 'package:base':
##
## I, expand.grid, unname
## Loading required package: IRanges
##
## Attaching package: 'IRanges'
## The following object is masked from 'package:grDevices':
##
## windows
## Loading required package: GenomeInfoDb
## Loading required package: Biobase
## Welcome to Bioconductor
##
## Vignettes contain introductory material; view with
## 'browseVignettes()'. To cite Bioconductor, see
## 'citation("Biobase")', and for packages 'citation("pkgname")'.
##
## Attaching package: 'Biobase'
## The following object is masked from 'package:MatrixGenerics':
##
## rowMedians
## The following objects are masked from 'package:matrixStats':
##
## anyMissing, rowMedians
prism_abundances <- system.file(
'extdata','demo_abundances.csv', package="Macarron")
prism_annotations <-system.file(
'extdata','demo_annotations.csv', package="Macarron")
prism_metadata <-system.file(
'extdata','demo_metadata.csv', package="Macarron")
mets_taxonomy <-system.file(
'extdata','demo_taxonomy.csv', package="Macarron")
prism_prioritized <- Macarron::Macarron(input_abundances = prism_abundances,
input_annotations = prism_annotations,
input_metadata = prism_metadata,
input_taxonomy = mets_taxonomy)
## 2024-06-26 19:47:41.81657 INFO::Creating output folder.
## 2024-06-26 19:47:41.841473 INFO::Writing function arguments to log file
## Samples with both abundances and metadata: 102
## 2024-06-26 19:47:41.926399 INFO::Summarized Experiment created.
## 2024-06-26 19:47:41.933505 INFO::Metadata chosen for prevalence filtering: diagnosis
## 869 features pass chosen minimum prevalence threshold of 0.7.
## Calculating pairwise correlations in phenotype: IBD
##
## Calculating pairwise correlations in phenotype: Control
## Distance matrix with 869 features created.
## 2024-06-26 19:47:47.339928 INFO::Distance matrix with 869 metabolic features created.
## Initiating module detection
## 2024-06-26 19:47:47.342263 INFO::Minimum module size used for this dataset: 10
## Tree constructed
## Evaluating measures of success
## ..cutHeight not given, setting it to 0.99 ===> 99% of the (truncated) height range in dendro.
## ..done.
## ..cutHeight not given, setting it to 0.99 ===> 99% of the (truncated) height range in dendro.
## ..done.
## ..cutHeight not given, setting it to 0.99 ===> 99% of the (truncated) height range in dendro.
## ..done.
## ..cutHeight not given, setting it to 0.99 ===> 99% of the (truncated) height range in dendro.
## ..done.
## ..cutHeight not given, setting it to 0.99 ===> 99% of the (truncated) height range in dendro.
## ..done.
## 2024-06-26 19:47:49.635709 INFO::Total number of modules detected: 30
## Initiating AVA calculations
## Finding anchors
## Calculating AVA
## Initiating q-value calculations
## [1] "Creating output folder"
## [1] "Creating output feature tables folder"
## [1] "Creating output fits folder"
## [1] "Creating output figures folder"
## 2024-06-26 19:47:52.346716 INFO::Writing function arguments to log file
## 2024-06-26 19:47:52.370167 INFO::Verifying options selected are valid
## 2024-06-26 19:47:52.436382 INFO::Determining format of input files
## 2024-06-26 19:47:52.438384 INFO::Input format is data samples as columns and metadata samples as rows
## 2024-06-26 19:47:52.460618 INFO::Formula for fixed effects: expr ~ diagnosis + age + antibiotics
## 2024-06-26 19:47:52.463293 INFO::Filter data based on min abundance and min prevalence
## 2024-06-26 19:47:52.465003 INFO::Total samples in data: 102
## 2024-06-26 19:47:52.466597 INFO::Min samples required with min abundance for a feature not to be filtered: 0.000000
## 2024-06-26 19:47:52.479849 INFO::Total filtered features: 0
## 2024-06-26 19:47:52.482801 INFO::Filtered feature names from abundance and prevalence filtering:
## 2024-06-26 19:47:52.510481 INFO::Total filtered features with variance filtering: 0
## 2024-06-26 19:47:52.513495 INFO::Filtered feature names from variance filtering:
## 2024-06-26 19:47:52.515627 INFO::Running selected normalization method: NONE
## 2024-06-26 19:47:52.51828 INFO::Applying z-score to standardize continuous metadata
## 2024-06-26 19:47:52.553571 INFO::Running selected transform method: NONE
## 2024-06-26 19:47:52.556493 INFO::Running selected analysis method: LM
## 2024-06-26 19:47:52.569715 INFO::Fitting model to feature number 1, F1
## 2024-06-26 19:47:52.585296 INFO::Fitting model to feature number 2, F2
## 2024-06-26 19:47:52.593084 INFO::Fitting model to feature number 3, F3
## 2024-06-26 19:47:52.600558 INFO::Fitting model to feature number 4, F4
## 2024-06-26 19:47:52.608188 INFO::Fitting model to feature number 5, F5
## 2024-06-26 19:47:52.615851 INFO::Fitting model to feature number 6, F6
## 2024-06-26 19:47:52.623806 INFO::Fitting model to feature number 7, F7
## 2024-06-26 19:47:52.63172 INFO::Fitting model to feature number 8, F8
## 2024-06-26 19:47:52.639524 INFO::Fitting model to feature number 9, F9
## 2024-06-26 19:47:52.647366 INFO::Fitting model to feature number 10, F10
## 2024-06-26 19:47:52.655154 INFO::Fitting model to feature number 11, F11
## 2024-06-26 19:47:52.663088 INFO::Fitting model to feature number 12, F12
## 2024-06-26 19:47:52.670887 INFO::Fitting model to feature number 13, F13
## 2024-06-26 19:47:52.678728 INFO::Fitting model to feature number 14, F14
## 2024-06-26 19:47:52.686529 INFO::Fitting model to feature number 15, F15
## 2024-06-26 19:47:52.694368 INFO::Fitting model to feature number 16, F16
## 2024-06-26 19:47:52.702216 INFO::Fitting model to feature number 17, F17
## 2024-06-26 19:47:52.710172 INFO::Fitting model to feature number 18, F18
## 2024-06-26 19:47:52.71799 INFO::Fitting model to feature number 19, F19
## 2024-06-26 19:47:52.725757 INFO::Fitting model to feature number 20, F20
## 2024-06-26 19:47:52.733653 INFO::Fitting model to feature number 21, F21
## 2024-06-26 19:47:52.741665 INFO::Fitting model to feature number 22, F22
## 2024-06-26 19:47:52.749489 INFO::Fitting model to feature number 23, F23
## 2024-06-26 19:47:52.757336 INFO::Fitting model to feature number 24, F24
## 2024-06-26 19:47:52.765203 INFO::Fitting model to feature number 25, F25
## 2024-06-26 19:47:52.77315 INFO::Fitting model to feature number 26, F26
## 2024-06-26 19:47:52.780829 INFO::Fitting model to feature number 27, F27
## 2024-06-26 19:47:52.788487 INFO::Fitting model to feature number 28, F28
## 2024-06-26 19:47:52.796399 INFO::Fitting model to feature number 29, F29
## 2024-06-26 19:47:52.804334 INFO::Fitting model to feature number 30, F30
## 2024-06-26 19:47:52.812147 INFO::Fitting model to feature number 31, F31
## 2024-06-26 19:47:52.820408 INFO::Fitting model to feature number 32, F32
## 2024-06-26 19:47:52.82698 INFO::Fitting model to feature number 33, F33
## 2024-06-26 19:47:52.832847 INFO::Fitting model to feature number 34, F34
## 2024-06-26 19:47:52.838583 INFO::Fitting model to feature number 35, F35
## 2024-06-26 19:47:52.844417 INFO::Fitting model to feature number 36, F36
## 2024-06-26 19:47:52.849556 INFO::Fitting model to feature number 37, F37
## 2024-06-26 19:47:52.85496 INFO::Fitting model to feature number 38, F38
## 2024-06-26 19:47:52.860202 INFO::Fitting model to feature number 39, F39
## 2024-06-26 19:47:52.865195 INFO::Fitting model to feature number 40, F40
## 2024-06-26 19:47:52.870247 INFO::Fitting model to feature number 41, F41
## 2024-06-26 19:47:52.87617 INFO::Fitting model to feature number 42, F43
## 2024-06-26 19:47:52.881487 INFO::Fitting model to feature number 43, F44
## 2024-06-26 19:47:52.886641 INFO::Fitting model to feature number 44, F45
## 2024-06-26 19:47:52.8924 INFO::Fitting model to feature number 45, F46
## 2024-06-26 19:47:52.900221 INFO::Fitting model to feature number 46, F47
## 2024-06-26 19:47:52.90763 INFO::Fitting model to feature number 47, F48
## 2024-06-26 19:47:52.912583 INFO::Fitting model to feature number 48, F49
## 2024-06-26 19:47:52.917421 INFO::Fitting model to feature number 49, F50
## 2024-06-26 19:47:52.922206 INFO::Fitting model to feature number 50, F51
## 2024-06-26 19:47:52.926998 INFO::Fitting model to feature number 51, F52
## 2024-06-26 19:47:52.931737 INFO::Fitting model to feature number 52, F53
## 2024-06-26 19:47:52.936461 INFO::Fitting model to feature number 53, F54
## 2024-06-26 19:47:52.941202 INFO::Fitting model to feature number 54, F55
## 2024-06-26 19:47:52.945917 INFO::Fitting model to feature number 55, F56
## 2024-06-26 19:47:52.950691 INFO::Fitting model to feature number 56, F57
## 2024-06-26 19:47:52.9555 INFO::Fitting model to feature number 57, F58
## 2024-06-26 19:47:52.960343 INFO::Fitting model to feature number 58, F59
## 2024-06-26 19:47:52.966953 INFO::Fitting model to feature number 59, F60
## 2024-06-26 19:47:52.97431 INFO::Fitting model to feature number 60, F63
## 2024-06-26 19:47:52.979461 INFO::Fitting model to feature number 61, F64
## 2024-06-26 19:47:52.984525 INFO::Fitting model to feature number 62, F65
## 2024-06-26 19:47:52.989584 INFO::Fitting model to feature number 63, F66
## 2024-06-26 19:47:52.994445 INFO::Fitting model to feature number 64, F67
## 2024-06-26 19:47:52.999283 INFO::Fitting model to feature number 65, F68
## 2024-06-26 19:47:53.004169 INFO::Fitting model to feature number 66, F69
## 2024-06-26 19:47:53.009015 INFO::Fitting model to feature number 67, F70
## 2024-06-26 19:47:53.013865 INFO::Fitting model to feature number 68, F71
## 2024-06-26 19:47:53.018827 INFO::Fitting model to feature number 69, F72
## 2024-06-26 19:47:53.024311 INFO::Fitting model to feature number 70, F73
## 2024-06-26 19:47:53.029676 INFO::Fitting model to feature number 71, F74
## 2024-06-26 19:47:53.034685 INFO::Fitting model to feature number 72, F76
## 2024-06-26 19:47:53.039679 INFO::Fitting model to feature number 73, F77
## 2024-06-26 19:47:53.045148 INFO::Fitting model to feature number 74, F78
## 2024-06-26 19:47:53.050236 INFO::Fitting model to feature number 75, F79
## 2024-06-26 19:47:53.055137 INFO::Fitting model to feature number 76, F80
## 2024-06-26 19:47:53.060026 INFO::Fitting model to feature number 77, F81
## 2024-06-26 19:47:53.064975 INFO::Fitting model to feature number 78, F82
## 2024-06-26 19:47:53.069854 INFO::Fitting model to feature number 79, F83
## 2024-06-26 19:47:53.074749 INFO::Fitting model to feature number 80, F84
## 2024-06-26 19:47:53.080039 INFO::Fitting model to feature number 81, F85
## 2024-06-26 19:47:53.08495 INFO::Fitting model to feature number 82, F86
## 2024-06-26 19:47:53.089764 INFO::Fitting model to feature number 83, F87
## 2024-06-26 19:47:53.094686 INFO::Fitting model to feature number 84, F88
## 2024-06-26 19:47:53.099516 INFO::Fitting model to feature number 85, F89
## 2024-06-26 19:47:53.104662 INFO::Fitting model to feature number 86, F90
## 2024-06-26 19:47:53.109733 INFO::Fitting model to feature number 87, F91
## 2024-06-26 19:47:53.114857 INFO::Fitting model to feature number 88, F92
## 2024-06-26 19:47:53.12011 INFO::Fitting model to feature number 89, F93
## 2024-06-26 19:47:53.125005 INFO::Fitting model to feature number 90, F94
## 2024-06-26 19:47:53.129931 INFO::Fitting model to feature number 91, F95
## 2024-06-26 19:47:53.134825 INFO::Fitting model to feature number 92, F96
## 2024-06-26 19:47:53.140189 INFO::Fitting model to feature number 93, F97
## 2024-06-26 19:47:53.146435 INFO::Fitting model to feature number 94, F98
## 2024-06-26 19:47:53.15131 INFO::Fitting model to feature number 95, F99
## 2024-06-26 19:47:53.156408 INFO::Fitting model to feature number 96, F100
## 2024-06-26 19:47:53.161381 INFO::Fitting model to feature number 97, F101
## 2024-06-26 19:47:53.167226 INFO::Fitting model to feature number 98, F102
## 2024-06-26 19:47:53.172434 INFO::Fitting model to feature number 99, F103
## 2024-06-26 19:47:53.17817 INFO::Fitting model to feature number 100, F104
## 2024-06-26 19:47:53.183506 INFO::Fitting model to feature number 101, F105
## 2024-06-26 19:47:53.188761 INFO::Fitting model to feature number 102, F106
## 2024-06-26 19:47:53.193718 INFO::Fitting model to feature number 103, F107
## 2024-06-26 19:47:53.198634 INFO::Fitting model to feature number 104, F108
## 2024-06-26 19:47:53.20467 INFO::Fitting model to feature number 105, F109
## 2024-06-26 19:47:53.209822 INFO::Fitting model to feature number 106, F110
## 2024-06-26 19:47:53.215321 INFO::Fitting model to feature number 107, F111
## 2024-06-26 19:47:53.221602 INFO::Fitting model to feature number 108, F112
## 2024-06-26 19:47:53.232306 INFO::Fitting model to feature number 109, F113
## 2024-06-26 19:47:53.237744 INFO::Fitting model to feature number 110, F114
## 2024-06-26 19:47:53.243469 INFO::Fitting model to feature number 111, F115
## 2024-06-26 19:47:53.249341 INFO::Fitting model to feature number 112, F117
## 2024-06-26 19:47:53.254906 INFO::Fitting model to feature number 113, F118
## 2024-06-26 19:47:53.260082 INFO::Fitting model to feature number 114, F119
## 2024-06-26 19:47:53.26522 INFO::Fitting model to feature number 115, F120
## 2024-06-26 19:47:53.270312 INFO::Fitting model to feature number 116, F121
## 2024-06-26 19:47:53.275372 INFO::Fitting model to feature number 117, F122
## 2024-06-26 19:47:53.280381 INFO::Fitting model to feature number 118, F123
## 2024-06-26 19:47:53.285454 INFO::Fitting model to feature number 119, F124
## 2024-06-26 19:47:53.29038 INFO::Fitting model to feature number 120, F125
## 2024-06-26 19:47:53.295342 INFO::Fitting model to feature number 121, F126
## 2024-06-26 19:47:53.300409 INFO::Fitting model to feature number 122, F127
## 2024-06-26 19:47:53.305354 INFO::Fitting model to feature number 123, F128
## 2024-06-26 19:47:53.310291 INFO::Fitting model to feature number 124, F129
## 2024-06-26 19:47:53.315377 INFO::Fitting model to feature number 125, F130
## 2024-06-26 19:47:53.320328 INFO::Fitting model to feature number 126, F131
## 2024-06-26 19:47:53.325221 INFO::Fitting model to feature number 127, F132
## 2024-06-26 19:47:53.330274 INFO::Fitting model to feature number 128, F133
## 2024-06-26 19:47:53.335333 INFO::Fitting model to feature number 129, F134
## 2024-06-26 19:47:53.340379 INFO::Fitting model to feature number 130, F135
## 2024-06-26 19:47:53.345467 INFO::Fitting model to feature number 131, F136
## 2024-06-26 19:47:53.350491 INFO::Fitting model to feature number 132, F137
## 2024-06-26 19:47:53.355411 INFO::Fitting model to feature number 133, F138
## 2024-06-26 19:47:53.360358 INFO::Fitting model to feature number 134, F139
## 2024-06-26 19:47:53.365393 INFO::Fitting model to feature number 135, F140
## 2024-06-26 19:47:53.372591 INFO::Fitting model to feature number 136, F141
## 2024-06-26 19:47:53.380915 INFO::Fitting model to feature number 137, F142
## 2024-06-26 19:47:53.388953 INFO::Fitting model to feature number 138, F143
## 2024-06-26 19:47:53.394252 INFO::Fitting model to feature number 139, F144
## 2024-06-26 19:47:53.399368 INFO::Fitting model to feature number 140, F145
## 2024-06-26 19:47:53.405011 INFO::Fitting model to feature number 141, F146
## 2024-06-26 19:47:53.410921 INFO::Fitting model to feature number 142, F147
## 2024-06-26 19:47:53.419322 INFO::Fitting model to feature number 143, F148
## 2024-06-26 19:47:53.428131 INFO::Fitting model to feature number 144, F149
## 2024-06-26 19:47:53.437376 INFO::Fitting model to feature number 145, F150
## 2024-06-26 19:47:53.446101 INFO::Fitting model to feature number 146, F152
## 2024-06-26 19:47:53.454806 INFO::Fitting model to feature number 147, F153
## 2024-06-26 19:47:53.463037 INFO::Fitting model to feature number 148, F154
## 2024-06-26 19:47:53.471446 INFO::Fitting model to feature number 149, F155
## 2024-06-26 19:47:53.479704 INFO::Fitting model to feature number 150, F156
## 2024-06-26 19:47:53.487964 INFO::Fitting model to feature number 151, F157
## 2024-06-26 19:47:53.496204 INFO::Fitting model to feature number 152, F158
## 2024-06-26 19:47:53.504011 INFO::Fitting model to feature number 153, F159
## 2024-06-26 19:47:53.515966 INFO::Fitting model to feature number 154, F160
## 2024-06-26 19:47:53.523791 INFO::Fitting model to feature number 155, F161
## 2024-06-26 19:47:53.531453 INFO::Fitting model to feature number 156, F162
## 2024-06-26 19:47:53.539242 INFO::Fitting model to feature number 157, F163
## 2024-06-26 19:47:53.546762 INFO::Fitting model to feature number 158, F164
## 2024-06-26 19:47:53.555674 INFO::Fitting model to feature number 159, F165
## 2024-06-26 19:47:53.56724 INFO::Fitting model to feature number 160, F166
## 2024-06-26 19:47:53.576131 INFO::Fitting model to feature number 161, F167
## 2024-06-26 19:47:53.584095 INFO::Fitting model to feature number 162, F168
## 2024-06-26 19:47:53.592145 INFO::Fitting model to feature number 163, F169
## 2024-06-26 19:47:53.600231 INFO::Fitting model to feature number 164, F170
## 2024-06-26 19:47:53.608522 INFO::Fitting model to feature number 165, F171
## 2024-06-26 19:47:53.616791 INFO::Fitting model to feature number 166, F172
## 2024-06-26 19:47:53.624994 INFO::Fitting model to feature number 167, F173
## 2024-06-26 19:47:53.632945 INFO::Fitting model to feature number 168, F174
## 2024-06-26 19:47:53.641039 INFO::Fitting model to feature number 169, F175
## 2024-06-26 19:47:53.649163 INFO::Fitting model to feature number 170, F176
## 2024-06-26 19:47:53.657098 INFO::Fitting model to feature number 171, F177
## 2024-06-26 19:47:53.665065 INFO::Fitting model to feature number 172, F178
## 2024-06-26 19:47:53.672748 INFO::Fitting model to feature number 173, F179
## 2024-06-26 19:47:53.680288 INFO::Fitting model to feature number 174, F180
## 2024-06-26 19:47:53.688152 INFO::Fitting model to feature number 175, F181
## 2024-06-26 19:47:53.695997 INFO::Fitting model to feature number 176, F182
## 2024-06-26 19:47:53.701879 INFO::Fitting model to feature number 177, F183
## 2024-06-26 19:47:53.709714 INFO::Fitting model to feature number 178, F184
## 2024-06-26 19:47:53.717747 INFO::Fitting model to feature number 179, F185
## 2024-06-26 19:47:53.724574 INFO::Fitting model to feature number 180, F186
## 2024-06-26 19:47:53.732126 INFO::Fitting model to feature number 181, F187
## 2024-06-26 19:47:53.739613 INFO::Fitting model to feature number 182, F188
## 2024-06-26 19:47:53.744552 INFO::Fitting model to feature number 183, F189
## 2024-06-26 19:47:53.749458 INFO::Fitting model to feature number 184, F190
## 2024-06-26 19:47:53.754485 INFO::Fitting model to feature number 185, F191
## 2024-06-26 19:47:53.759361 INFO::Fitting model to feature number 186, F192
## 2024-06-26 19:47:53.764155 INFO::Fitting model to feature number 187, F193
## 2024-06-26 19:47:53.768902 INFO::Fitting model to feature number 188, F194
## 2024-06-26 19:47:53.773736 INFO::Fitting model to feature number 189, F195
## 2024-06-26 19:47:53.778677 INFO::Fitting model to feature number 190, F196
## 2024-06-26 19:47:53.783543 INFO::Fitting model to feature number 191, F197
## 2024-06-26 19:47:53.788494 INFO::Fitting model to feature number 192, F198
## 2024-06-26 19:47:53.793323 INFO::Fitting model to feature number 193, F199
## 2024-06-26 19:47:53.798618 INFO::Fitting model to feature number 194, F200
## 2024-06-26 19:47:53.806346 INFO::Fitting model to feature number 195, F201
## 2024-06-26 19:47:53.813903 INFO::Fitting model to feature number 196, F202
## 2024-06-26 19:47:53.820796 INFO::Fitting model to feature number 197, F203
## 2024-06-26 19:47:53.825764 INFO::Fitting model to feature number 198, F204
## 2024-06-26 19:47:53.831044 INFO::Fitting model to feature number 199, F206
## 2024-06-26 19:47:53.838375 INFO::Fitting model to feature number 200, F207
## 2024-06-26 19:47:53.845787 INFO::Fitting model to feature number 201, F208
## 2024-06-26 19:47:53.853203 INFO::Fitting model to feature number 202, F209
## 2024-06-26 19:47:53.860514 INFO::Fitting model to feature number 203, F210
## 2024-06-26 19:47:53.868187 INFO::Fitting model to feature number 204, F211
## 2024-06-26 19:47:53.876491 INFO::Fitting model to feature number 205, F212
## 2024-06-26 19:47:53.884645 INFO::Fitting model to feature number 206, F213
## 2024-06-26 19:47:53.892361 INFO::Fitting model to feature number 207, F214
## 2024-06-26 19:47:53.899672 INFO::Fitting model to feature number 208, F215
## 2024-06-26 19:47:53.906794 INFO::Fitting model to feature number 209, F216
## 2024-06-26 19:47:53.914018 INFO::Fitting model to feature number 210, F217
## 2024-06-26 19:47:53.921087 INFO::Fitting model to feature number 211, F218
## 2024-06-26 19:47:53.928138 INFO::Fitting model to feature number 212, F219
## 2024-06-26 19:47:53.93517 INFO::Fitting model to feature number 213, F220
## 2024-06-26 19:47:53.942265 INFO::Fitting model to feature number 214, F221
## 2024-06-26 19:47:53.949324 INFO::Fitting model to feature number 215, F222
## 2024-06-26 19:47:53.956401 INFO::Fitting model to feature number 216, F223
## 2024-06-26 19:47:53.963568 INFO::Fitting model to feature number 217, F224
## 2024-06-26 19:47:53.969303 INFO::Fitting model to feature number 218, F225
## 2024-06-26 19:47:53.974369 INFO::Fitting model to feature number 219, F226
## 2024-06-26 19:47:53.979567 INFO::Fitting model to feature number 220, F227
## 2024-06-26 19:47:53.984474 INFO::Fitting model to feature number 221, F228
## 2024-06-26 19:47:53.989578 INFO::Fitting model to feature number 222, F229
## 2024-06-26 19:47:53.994522 INFO::Fitting model to feature number 223, F230
## 2024-06-26 19:47:53.999379 INFO::Fitting model to feature number 224, F231
## 2024-06-26 19:47:54.004244 INFO::Fitting model to feature number 225, F232
## 2024-06-26 19:47:54.009128 INFO::Fitting model to feature number 226, F233
## 2024-06-26 19:47:54.015372 INFO::Fitting model to feature number 227, F234
## 2024-06-26 19:47:54.023201 INFO::Fitting model to feature number 228, F235
## 2024-06-26 19:47:54.030837 INFO::Fitting model to feature number 229, F236
## 2024-06-26 19:47:54.038511 INFO::Fitting model to feature number 230, F237
## 2024-06-26 19:47:54.046233 INFO::Fitting model to feature number 231, F238
## 2024-06-26 19:47:54.053782 INFO::Fitting model to feature number 232, F239
## 2024-06-26 19:47:54.061535 INFO::Fitting model to feature number 233, F240
## 2024-06-26 19:47:54.06915 INFO::Fitting model to feature number 234, F241
## 2024-06-26 19:47:54.076505 INFO::Fitting model to feature number 235, F242
## 2024-06-26 19:47:54.084165 INFO::Fitting model to feature number 236, F243
## 2024-06-26 19:47:54.09059 INFO::Fitting model to feature number 237, F244
## 2024-06-26 19:47:54.095713 INFO::Fitting model to feature number 238, F245
## 2024-06-26 19:47:54.101308 INFO::Fitting model to feature number 239, F246
## 2024-06-26 19:47:54.107956 INFO::Fitting model to feature number 240, F247
## 2024-06-26 19:47:54.115769 INFO::Fitting model to feature number 241, F248
## 2024-06-26 19:47:54.12392 INFO::Fitting model to feature number 242, F249
## 2024-06-26 19:47:54.133336 INFO::Fitting model to feature number 243, F250
## 2024-06-26 19:47:54.141342 INFO::Fitting model to feature number 244, F252
## 2024-06-26 19:47:54.148141 INFO::Fitting model to feature number 245, F253
## 2024-06-26 19:47:54.153448 INFO::Fitting model to feature number 246, F254
## 2024-06-26 19:47:54.158955 INFO::Fitting model to feature number 247, F255
## 2024-06-26 19:47:54.164783 INFO::Fitting model to feature number 248, F256
## 2024-06-26 19:47:54.169987 INFO::Fitting model to feature number 249, F257
## 2024-06-26 19:47:54.175266 INFO::Fitting model to feature number 250, F259
## 2024-06-26 19:47:54.180441 INFO::Fitting model to feature number 251, F260
## 2024-06-26 19:47:54.186677 INFO::Fitting model to feature number 252, F261
## 2024-06-26 19:47:54.194129 INFO::Fitting model to feature number 253, F262
## 2024-06-26 19:47:54.201758 INFO::Fitting model to feature number 254, F263
## 2024-06-26 19:47:54.209525 INFO::Fitting model to feature number 255, F264
## 2024-06-26 19:47:54.217312 INFO::Fitting model to feature number 256, F265
## 2024-06-26 19:47:54.225005 INFO::Fitting model to feature number 257, F266
## 2024-06-26 19:47:54.232629 INFO::Fitting model to feature number 258, F267
## 2024-06-26 19:47:54.283916 INFO::Fitting model to feature number 259, F269
## 2024-06-26 19:47:54.289334 INFO::Fitting model to feature number 260, F270
## 2024-06-26 19:47:54.294279 INFO::Fitting model to feature number 261, F271
## 2024-06-26 19:47:54.29917 INFO::Fitting model to feature number 262, F272
## 2024-06-26 19:47:54.304141 INFO::Fitting model to feature number 263, F273
## 2024-06-26 19:47:54.309018 INFO::Fitting model to feature number 264, F274
## 2024-06-26 19:47:54.313714 INFO::Fitting model to feature number 265, F276
## 2024-06-26 19:47:54.318732 INFO::Fitting model to feature number 266, F277
## 2024-06-26 19:47:54.323818 INFO::Fitting model to feature number 267, F278
## 2024-06-26 19:47:54.330163 INFO::Fitting model to feature number 268, F279
## 2024-06-26 19:47:54.33753 INFO::Fitting model to feature number 269, F280
## 2024-06-26 19:47:54.344966 INFO::Fitting model to feature number 270, F281
## 2024-06-26 19:47:54.352035 INFO::Fitting model to feature number 271, F282
## 2024-06-26 19:47:54.359196 INFO::Fitting model to feature number 272, F283
## 2024-06-26 19:47:54.366171 INFO::Fitting model to feature number 273, F284
## 2024-06-26 19:47:54.37428 INFO::Fitting model to feature number 274, F285
## 2024-06-26 19:47:54.382005 INFO::Fitting model to feature number 275, F286
## 2024-06-26 19:47:54.387514 INFO::Fitting model to feature number 276, F287
## 2024-06-26 19:47:54.392711 INFO::Fitting model to feature number 277, F288
## 2024-06-26 19:47:54.399791 INFO::Fitting model to feature number 278, F289
## 2024-06-26 19:47:54.405962 INFO::Fitting model to feature number 279, F290
## 2024-06-26 19:47:54.411333 INFO::Fitting model to feature number 280, F292
## 2024-06-26 19:47:54.417083 INFO::Fitting model to feature number 281, F293
## 2024-06-26 19:47:54.42209 INFO::Fitting model to feature number 282, F294
## 2024-06-26 19:47:54.429366 INFO::Fitting model to feature number 283, F295
## 2024-06-26 19:47:54.435119 INFO::Fitting model to feature number 284, F296
## 2024-06-26 19:47:54.440295 INFO::Fitting model to feature number 285, F297
## 2024-06-26 19:47:54.445207 INFO::Fitting model to feature number 286, F298
## 2024-06-26 19:47:54.450356 INFO::Fitting model to feature number 287, F299
## 2024-06-26 19:47:54.45521 INFO::Fitting model to feature number 288, F300
## 2024-06-26 19:47:54.460134 INFO::Fitting model to feature number 289, F301
## 2024-06-26 19:47:54.467318 INFO::Fitting model to feature number 290, F302
## 2024-06-26 19:47:54.473129 INFO::Fitting model to feature number 291, F303
## 2024-06-26 19:47:54.478834 INFO::Fitting model to feature number 292, F304
## 2024-06-26 19:47:54.484213 INFO::Fitting model to feature number 293, F305
## 2024-06-26 19:47:54.489708 INFO::Fitting model to feature number 294, F306
## 2024-06-26 19:47:54.494913 INFO::Fitting model to feature number 295, F307
## 2024-06-26 19:47:54.500264 INFO::Fitting model to feature number 296, F308
## 2024-06-26 19:47:54.507242 INFO::Fitting model to feature number 297, F309
## 2024-06-26 19:47:54.516214 INFO::Fitting model to feature number 298, F310
## 2024-06-26 19:47:54.522639 INFO::Fitting model to feature number 299, F311
## 2024-06-26 19:47:54.528256 INFO::Fitting model to feature number 300, F312
## 2024-06-26 19:47:54.533576 INFO::Fitting model to feature number 301, F313
## 2024-06-26 19:47:54.540569 INFO::Fitting model to feature number 302, F315
## 2024-06-26 19:47:54.54631 INFO::Fitting model to feature number 303, F316
## 2024-06-26 19:47:54.551631 INFO::Fitting model to feature number 304, F317
## 2024-06-26 19:47:54.557212 INFO::Fitting model to feature number 305, F318
## 2024-06-26 19:47:54.562285 INFO::Fitting model to feature number 306, F319
## 2024-06-26 19:47:54.567122 INFO::Fitting model to feature number 307, F320
## 2024-06-26 19:47:54.572288 INFO::Fitting model to feature number 308, F321
## 2024-06-26 19:47:54.579497 INFO::Fitting model to feature number 309, F322
## 2024-06-26 19:47:54.586695 INFO::Fitting model to feature number 310, F323
## 2024-06-26 19:47:54.592218 INFO::Fitting model to feature number 311, F324
## 2024-06-26 19:47:54.597509 INFO::Fitting model to feature number 312, F325
## 2024-06-26 19:47:54.603516 INFO::Fitting model to feature number 313, F326
## 2024-06-26 19:47:54.609212 INFO::Fitting model to feature number 314, F327
## 2024-06-26 19:47:54.614686 INFO::Fitting model to feature number 315, F328
## 2024-06-26 19:47:54.619885 INFO::Fitting model to feature number 316, F329
## 2024-06-26 19:47:54.625316 INFO::Fitting model to feature number 317, F330
## 2024-06-26 19:47:54.630724 INFO::Fitting model to feature number 318, F331
## 2024-06-26 19:47:54.638577 INFO::Fitting model to feature number 319, F332
## 2024-06-26 19:47:54.64662 INFO::Fitting model to feature number 320, F333
## 2024-06-26 19:47:54.65504 INFO::Fitting model to feature number 321, F334
## 2024-06-26 19:47:54.663404 INFO::Fitting model to feature number 322, F335
## 2024-06-26 19:47:54.671946 INFO::Fitting model to feature number 323, F336
## 2024-06-26 19:47:54.679721 INFO::Fitting model to feature number 324, F337
## 2024-06-26 19:47:54.68668 INFO::Fitting model to feature number 325, F338
## 2024-06-26 19:47:54.69407 INFO::Fitting model to feature number 326, F339
## 2024-06-26 19:47:54.699269 INFO::Fitting model to feature number 327, F340
## 2024-06-26 19:47:54.704714 INFO::Fitting model to feature number 328, F342
## 2024-06-26 19:47:54.709734 INFO::Fitting model to feature number 329, F343
## 2024-06-26 19:47:54.71507 INFO::Fitting model to feature number 330, F344
## 2024-06-26 19:47:54.720088 INFO::Fitting model to feature number 331, F345
## 2024-06-26 19:47:54.725103 INFO::Fitting model to feature number 332, F346
## 2024-06-26 19:47:54.729931 INFO::Fitting model to feature number 333, F347
## 2024-06-26 19:47:54.735855 INFO::Fitting model to feature number 334, F348
## 2024-06-26 19:47:54.741195 INFO::Fitting model to feature number 335, F350
## 2024-06-26 19:47:54.746513 INFO::Fitting model to feature number 336, F351
## 2024-06-26 19:47:54.752304 INFO::Fitting model to feature number 337, F352
## 2024-06-26 19:47:54.757692 INFO::Fitting model to feature number 338, F353
## 2024-06-26 19:47:54.763045 INFO::Fitting model to feature number 339, F355
## 2024-06-26 19:47:54.768202 INFO::Fitting model to feature number 340, F356
## 2024-06-26 19:47:54.77331 INFO::Fitting model to feature number 341, F357
## 2024-06-26 19:47:54.779933 INFO::Fitting model to feature number 342, F358
## 2024-06-26 19:47:54.787385 INFO::Fitting model to feature number 343, F359
## 2024-06-26 19:47:54.794653 INFO::Fitting model to feature number 344, F360
## 2024-06-26 19:47:54.801916 INFO::Fitting model to feature number 345, F361
## 2024-06-26 19:47:54.809102 INFO::Fitting model to feature number 346, F362
## 2024-06-26 19:47:54.816341 INFO::Fitting model to feature number 347, F363
## 2024-06-26 19:47:54.823491 INFO::Fitting model to feature number 348, F364
## 2024-06-26 19:47:54.830681 INFO::Fitting model to feature number 349, F365
## 2024-06-26 19:47:54.837961 INFO::Fitting model to feature number 350, F366
## 2024-06-26 19:47:54.845262 INFO::Fitting model to feature number 351, F367
## 2024-06-26 19:47:54.852212 INFO::Fitting model to feature number 352, F368
## 2024-06-26 19:47:54.859747 INFO::Fitting model to feature number 353, F369
## 2024-06-26 19:47:54.867257 INFO::Fitting model to feature number 354, F370
## 2024-06-26 19:47:54.874658 INFO::Fitting model to feature number 355, F371
## 2024-06-26 19:47:54.881997 INFO::Fitting model to feature number 356, F372
## 2024-06-26 19:47:54.889209 INFO::Fitting model to feature number 357, F373
## 2024-06-26 19:47:54.896566 INFO::Fitting model to feature number 358, F374
## 2024-06-26 19:47:54.903874 INFO::Fitting model to feature number 359, F375
## 2024-06-26 19:47:54.911092 INFO::Fitting model to feature number 360, F376
## 2024-06-26 19:47:54.918098 INFO::Fitting model to feature number 361, F377
## 2024-06-26 19:47:54.925285 INFO::Fitting model to feature number 362, F378
## 2024-06-26 19:47:54.9326 INFO::Fitting model to feature number 363, F379
## 2024-06-26 19:47:54.939609 INFO::Fitting model to feature number 364, F380
## 2024-06-26 19:47:54.945556 INFO::Fitting model to feature number 365, F381
## 2024-06-26 19:47:54.950554 INFO::Fitting model to feature number 366, F382
## 2024-06-26 19:47:54.955457 INFO::Fitting model to feature number 367, F383
## 2024-06-26 19:47:54.960425 INFO::Fitting model to feature number 368, F384
## 2024-06-26 19:47:54.966327 INFO::Fitting model to feature number 369, F386
## 2024-06-26 19:47:54.971267 INFO::Fitting model to feature number 370, F387
## 2024-06-26 19:47:54.976417 INFO::Fitting model to feature number 371, F388
## 2024-06-26 19:47:54.981134 INFO::Fitting model to feature number 372, F389
## 2024-06-26 19:47:54.985845 INFO::Fitting model to feature number 373, F390
## 2024-06-26 19:47:54.9922 INFO::Fitting model to feature number 374, F391
## 2024-06-26 19:47:54.999625 INFO::Fitting model to feature number 375, F392
## 2024-06-26 19:47:55.00564 INFO::Fitting model to feature number 376, F393
## 2024-06-26 19:47:55.010522 INFO::Fitting model to feature number 377, F394
## 2024-06-26 19:47:55.015454 INFO::Fitting model to feature number 378, F395
## 2024-06-26 19:47:55.022788 INFO::Fitting model to feature number 379, F396
## 2024-06-26 19:47:55.030348 INFO::Fitting model to feature number 380, F397
## 2024-06-26 19:47:55.038157 INFO::Fitting model to feature number 381, F398
## 2024-06-26 19:47:55.045543 INFO::Fitting model to feature number 382, F399
## 2024-06-26 19:47:55.052911 INFO::Fitting model to feature number 383, F400
## 2024-06-26 19:47:55.060429 INFO::Fitting model to feature number 384, F401
## 2024-06-26 19:47:55.068728 INFO::Fitting model to feature number 385, F402
## 2024-06-26 19:47:55.076071 INFO::Fitting model to feature number 386, F403
## 2024-06-26 19:47:55.083669 INFO::Fitting model to feature number 387, F404
## 2024-06-26 19:47:55.091047 INFO::Fitting model to feature number 388, F406
## 2024-06-26 19:47:55.098926 INFO::Fitting model to feature number 389, F407
## 2024-06-26 19:47:55.106439 INFO::Fitting model to feature number 390, F408
## 2024-06-26 19:47:55.114188 INFO::Fitting model to feature number 391, F409
## 2024-06-26 19:47:55.121785 INFO::Fitting model to feature number 392, F410
## 2024-06-26 19:47:55.129592 INFO::Fitting model to feature number 393, F411
## 2024-06-26 19:47:55.136845 INFO::Fitting model to feature number 394, F412
## 2024-06-26 19:47:55.144826 INFO::Fitting model to feature number 395, F413
## 2024-06-26 19:47:55.153073 INFO::Fitting model to feature number 396, F414
## 2024-06-26 19:47:55.164082 INFO::Fitting model to feature number 397, F415
## 2024-06-26 19:47:55.172493 INFO::Fitting model to feature number 398, F416
## 2024-06-26 19:47:55.180381 INFO::Fitting model to feature number 399, F417
## 2024-06-26 19:47:55.188447 INFO::Fitting model to feature number 400, F418
## 2024-06-26 19:47:55.196372 INFO::Fitting model to feature number 401, F419
## 2024-06-26 19:47:55.204047 INFO::Fitting model to feature number 402, F420
## 2024-06-26 19:47:55.211767 INFO::Fitting model to feature number 403, F421
## 2024-06-26 19:47:55.219531 INFO::Fitting model to feature number 404, F422
## 2024-06-26 19:47:55.227131 INFO::Fitting model to feature number 405, F423
## 2024-06-26 19:47:55.234762 INFO::Fitting model to feature number 406, F425
## 2024-06-26 19:47:55.24259 INFO::Fitting model to feature number 407, F426
## 2024-06-26 19:47:55.250575 INFO::Fitting model to feature number 408, F428
## 2024-06-26 19:47:55.258881 INFO::Fitting model to feature number 409, F429
## 2024-06-26 19:47:55.267247 INFO::Fitting model to feature number 410, F430
## 2024-06-26 19:47:55.276711 INFO::Fitting model to feature number 411, F431
## 2024-06-26 19:47:55.285554 INFO::Fitting model to feature number 412, F432
## 2024-06-26 19:47:55.294135 INFO::Fitting model to feature number 413, F433
## 2024-06-26 19:47:55.302961 INFO::Fitting model to feature number 414, F434
## 2024-06-26 19:47:55.311586 INFO::Fitting model to feature number 415, F435
## 2024-06-26 19:47:55.321189 INFO::Fitting model to feature number 416, F436
## 2024-06-26 19:47:55.330994 INFO::Fitting model to feature number 417, F437
## 2024-06-26 19:47:55.340694 INFO::Fitting model to feature number 418, F438
## 2024-06-26 19:47:55.350536 INFO::Fitting model to feature number 419, F439
## 2024-06-26 19:47:55.357028 INFO::Fitting model to feature number 420, F440
## 2024-06-26 19:47:55.362539 INFO::Fitting model to feature number 421, F441
## 2024-06-26 19:47:55.367666 INFO::Fitting model to feature number 422, F442
## 2024-06-26 19:47:55.372497 INFO::Fitting model to feature number 423, F443
## 2024-06-26 19:47:55.377491 INFO::Fitting model to feature number 424, F444
## 2024-06-26 19:47:55.3825 INFO::Fitting model to feature number 425, F445
## 2024-06-26 19:47:55.387454 INFO::Fitting model to feature number 426, F446
## 2024-06-26 19:47:55.394503 INFO::Fitting model to feature number 427, F447
## 2024-06-26 19:47:55.39991 INFO::Fitting model to feature number 428, F448
## 2024-06-26 19:47:55.405169 INFO::Fitting model to feature number 429, F449
## 2024-06-26 19:47:55.41006 INFO::Fitting model to feature number 430, F450
## 2024-06-26 19:47:55.41565 INFO::Fitting model to feature number 431, F451
## 2024-06-26 19:47:55.420818 INFO::Fitting model to feature number 432, F452
## 2024-06-26 19:47:55.425685 INFO::Fitting model to feature number 433, F454
## 2024-06-26 19:47:55.430813 INFO::Fitting model to feature number 434, F455
## 2024-06-26 19:47:55.435918 INFO::Fitting model to feature number 435, F456
## 2024-06-26 19:47:55.44085 INFO::Fitting model to feature number 436, F457
## 2024-06-26 19:47:55.446375 INFO::Fitting model to feature number 437, F458
## 2024-06-26 19:47:55.451497 INFO::Fitting model to feature number 438, F459
## 2024-06-26 19:47:55.456299 INFO::Fitting model to feature number 439, F461
## 2024-06-26 19:47:55.461131 INFO::Fitting model to feature number 440, F462
## 2024-06-26 19:47:55.468328 INFO::Fitting model to feature number 441, F463
## 2024-06-26 19:47:55.475872 INFO::Fitting model to feature number 442, F464
## 2024-06-26 19:47:55.483759 INFO::Fitting model to feature number 443, F465
## 2024-06-26 19:47:55.491567 INFO::Fitting model to feature number 444, F466
## 2024-06-26 19:47:55.498206 INFO::Fitting model to feature number 445, F467
## 2024-06-26 19:47:55.504453 INFO::Fitting model to feature number 446, F468
## 2024-06-26 19:47:55.511961 INFO::Fitting model to feature number 447, F469
## 2024-06-26 19:47:55.519199 INFO::Fitting model to feature number 448, F470
## 2024-06-26 19:47:55.525932 INFO::Fitting model to feature number 449, F471
## 2024-06-26 19:47:55.531304 INFO::Fitting model to feature number 450, F474
## 2024-06-26 19:47:55.536247 INFO::Fitting model to feature number 451, F475
## 2024-06-26 19:47:55.541352 INFO::Fitting model to feature number 452, F476
## 2024-06-26 19:47:55.547877 INFO::Fitting model to feature number 453, F477
## 2024-06-26 19:47:55.555618 INFO::Fitting model to feature number 454, F478
## 2024-06-26 19:47:55.56106 INFO::Fitting model to feature number 455, F479
## 2024-06-26 19:47:55.566358 INFO::Fitting model to feature number 456, F480
## 2024-06-26 19:47:55.571533 INFO::Fitting model to feature number 457, F481
## 2024-06-26 19:47:55.577117 INFO::Fitting model to feature number 458, F482
## 2024-06-26 19:47:55.582241 INFO::Fitting model to feature number 459, F483
## 2024-06-26 19:47:55.587258 INFO::Fitting model to feature number 460, F484
## 2024-06-26 19:47:55.592072 INFO::Fitting model to feature number 461, F485
## 2024-06-26 19:47:55.596883 INFO::Fitting model to feature number 462, F486
## 2024-06-26 19:47:55.601757 INFO::Fitting model to feature number 463, F487
## 2024-06-26 19:47:55.606709 INFO::Fitting model to feature number 464, F488
## 2024-06-26 19:47:55.611573 INFO::Fitting model to feature number 465, F489
## 2024-06-26 19:47:55.616486 INFO::Fitting model to feature number 466, F490
## 2024-06-26 19:47:55.621439 INFO::Fitting model to feature number 467, F491
## 2024-06-26 19:47:55.626457 INFO::Fitting model to feature number 468, F492
## 2024-06-26 19:47:55.631434 INFO::Fitting model to feature number 469, F493
## 2024-06-26 19:47:55.636464 INFO::Fitting model to feature number 470, F494
## 2024-06-26 19:47:55.641387 INFO::Fitting model to feature number 471, F495
## 2024-06-26 19:47:55.646366 INFO::Fitting model to feature number 472, F496
## 2024-06-26 19:47:55.651335 INFO::Fitting model to feature number 473, F497
## 2024-06-26 19:47:55.656226 INFO::Fitting model to feature number 474, F498
## 2024-06-26 19:47:55.661063 INFO::Fitting model to feature number 475, F499
## 2024-06-26 19:47:55.666375 INFO::Fitting model to feature number 476, F500
## 2024-06-26 19:47:55.672148 INFO::Fitting model to feature number 477, F501
## 2024-06-26 19:47:55.67764 INFO::Fitting model to feature number 478, F502
## 2024-06-26 19:47:55.683079 INFO::Fitting model to feature number 479, F503
## 2024-06-26 19:47:55.688799 INFO::Fitting model to feature number 480, F504
## 2024-06-26 19:47:55.693703 INFO::Fitting model to feature number 481, F505
## 2024-06-26 19:47:55.698594 INFO::Fitting model to feature number 482, F506
## 2024-06-26 19:47:55.703489 INFO::Fitting model to feature number 483, F507
## 2024-06-26 19:47:55.708391 INFO::Fitting model to feature number 484, F508
## 2024-06-26 19:47:55.713401 INFO::Fitting model to feature number 485, F509
## 2024-06-26 19:47:55.718326 INFO::Fitting model to feature number 486, F510
## 2024-06-26 19:47:55.723311 INFO::Fitting model to feature number 487, F511
## 2024-06-26 19:47:55.728415 INFO::Fitting model to feature number 488, F512
## 2024-06-26 19:47:55.733427 INFO::Fitting model to feature number 489, F513
## 2024-06-26 19:47:55.738385 INFO::Fitting model to feature number 490, F514
## 2024-06-26 19:47:55.743347 INFO::Fitting model to feature number 491, F515
## 2024-06-26 19:47:55.748357 INFO::Fitting model to feature number 492, F516
## 2024-06-26 19:47:55.753233 INFO::Fitting model to feature number 493, F517
## 2024-06-26 19:47:55.758064 INFO::Fitting model to feature number 494, F518
## 2024-06-26 19:47:55.76302 INFO::Fitting model to feature number 495, F519
## 2024-06-26 19:47:55.767913 INFO::Fitting model to feature number 496, F520
## 2024-06-26 19:47:55.772783 INFO::Fitting model to feature number 497, F521
## 2024-06-26 19:47:55.777603 INFO::Fitting model to feature number 498, F522
## 2024-06-26 19:47:55.782468 INFO::Fitting model to feature number 499, F523
## 2024-06-26 19:47:55.787338 INFO::Fitting model to feature number 500, F524
## 2024-06-26 19:47:55.792287 INFO::Fitting model to feature number 501, F525
## 2024-06-26 19:47:55.797113 INFO::Fitting model to feature number 502, F526
## 2024-06-26 19:47:55.801971 INFO::Fitting model to feature number 503, F527
## 2024-06-26 19:47:55.806869 INFO::Fitting model to feature number 504, F528
## 2024-06-26 19:47:55.811586 INFO::Fitting model to feature number 505, F529
## 2024-06-26 19:47:55.816328 INFO::Fitting model to feature number 506, F530
## 2024-06-26 19:47:55.821047 INFO::Fitting model to feature number 507, F531
## 2024-06-26 19:47:55.82855 INFO::Fitting model to feature number 508, F532
## 2024-06-26 19:47:55.83589 INFO::Fitting model to feature number 509, F533
## 2024-06-26 19:47:55.843222 INFO::Fitting model to feature number 510, F534
## 2024-06-26 19:47:55.850577 INFO::Fitting model to feature number 511, F535
## 2024-06-26 19:47:55.855534 INFO::Fitting model to feature number 512, F536
## 2024-06-26 19:47:55.860379 INFO::Fitting model to feature number 513, F537
## 2024-06-26 19:47:55.865235 INFO::Fitting model to feature number 514, F539
## 2024-06-26 19:47:55.870092 INFO::Fitting model to feature number 515, F540
## 2024-06-26 19:47:55.876313 INFO::Fitting model to feature number 516, F541
## 2024-06-26 19:47:55.88122 INFO::Fitting model to feature number 517, F543
## 2024-06-26 19:47:55.886182 INFO::Fitting model to feature number 518, F544
## 2024-06-26 19:47:55.891088 INFO::Fitting model to feature number 519, F545
## 2024-06-26 19:47:55.896027 INFO::Fitting model to feature number 520, F546
## 2024-06-26 19:47:55.900927 INFO::Fitting model to feature number 521, F547
## 2024-06-26 19:47:55.905811 INFO::Fitting model to feature number 522, F548
## 2024-06-26 19:47:55.910625 INFO::Fitting model to feature number 523, F549
## 2024-06-26 19:47:55.915495 INFO::Fitting model to feature number 524, F550
## 2024-06-26 19:47:55.920365 INFO::Fitting model to feature number 525, F551
## 2024-06-26 19:47:55.925157 INFO::Fitting model to feature number 526, F552
## 2024-06-26 19:47:55.929948 INFO::Fitting model to feature number 527, F553
## 2024-06-26 19:47:55.934856 INFO::Fitting model to feature number 528, F554
## 2024-06-26 19:47:55.939693 INFO::Fitting model to feature number 529, F555
## 2024-06-26 19:47:55.944574 INFO::Fitting model to feature number 530, F556
## 2024-06-26 19:47:55.949496 INFO::Fitting model to feature number 531, F557
## 2024-06-26 19:47:55.954343 INFO::Fitting model to feature number 532, F558
## 2024-06-26 19:47:55.959214 INFO::Fitting model to feature number 533, F559
## 2024-06-26 19:47:55.96415 INFO::Fitting model to feature number 534, F560
## 2024-06-26 19:47:55.969004 INFO::Fitting model to feature number 535, F561
## 2024-06-26 19:47:55.973835 INFO::Fitting model to feature number 536, F562
## 2024-06-26 19:47:55.978721 INFO::Fitting model to feature number 537, F563
## 2024-06-26 19:47:55.983587 INFO::Fitting model to feature number 538, F564
## 2024-06-26 19:47:55.988385 INFO::Fitting model to feature number 539, F566
## 2024-06-26 19:47:55.993254 INFO::Fitting model to feature number 540, F567
## 2024-06-26 19:47:55.998228 INFO::Fitting model to feature number 541, F568
## 2024-06-26 19:47:56.00304 INFO::Fitting model to feature number 542, F569
## 2024-06-26 19:47:56.00786 INFO::Fitting model to feature number 543, F570
## 2024-06-26 19:47:56.01267 INFO::Fitting model to feature number 544, F571
## 2024-06-26 19:47:56.017409 INFO::Fitting model to feature number 545, F572
## 2024-06-26 19:47:56.022208 INFO::Fitting model to feature number 546, F573
## 2024-06-26 19:47:56.027024 INFO::Fitting model to feature number 547, F574
## 2024-06-26 19:47:56.031873 INFO::Fitting model to feature number 548, F575
## 2024-06-26 19:47:56.03683 INFO::Fitting model to feature number 549, F576
## 2024-06-26 19:47:56.041713 INFO::Fitting model to feature number 550, F577
## 2024-06-26 19:47:56.046503 INFO::Fitting model to feature number 551, F578
## 2024-06-26 19:47:56.051449 INFO::Fitting model to feature number 552, F579
## 2024-06-26 19:47:56.056586 INFO::Fitting model to feature number 553, F580
## 2024-06-26 19:47:56.063642 INFO::Fitting model to feature number 554, F581
## 2024-06-26 19:47:56.070785 INFO::Fitting model to feature number 555, F582
## 2024-06-26 19:47:56.077802 INFO::Fitting model to feature number 556, F583
## 2024-06-26 19:47:56.082735 INFO::Fitting model to feature number 557, F584
## 2024-06-26 19:47:56.087883 INFO::Fitting model to feature number 558, F585
## 2024-06-26 19:47:56.093828 INFO::Fitting model to feature number 559, F586
## 2024-06-26 19:47:56.098904 INFO::Fitting model to feature number 560, F587
## 2024-06-26 19:47:56.104311 INFO::Fitting model to feature number 561, F588
## 2024-06-26 19:47:56.109525 INFO::Fitting model to feature number 562, F589
## 2024-06-26 19:47:56.114767 INFO::Fitting model to feature number 563, F590
## 2024-06-26 19:47:56.120073 INFO::Fitting model to feature number 564, F591
## 2024-06-26 19:47:56.125198 INFO::Fitting model to feature number 565, F592
## 2024-06-26 19:47:56.130322 INFO::Fitting model to feature number 566, F593
## 2024-06-26 19:47:56.135532 INFO::Fitting model to feature number 567, F594
## 2024-06-26 19:47:56.140645 INFO::Fitting model to feature number 568, F595
## 2024-06-26 19:47:56.145758 INFO::Fitting model to feature number 569, F596
## 2024-06-26 19:47:56.150846 INFO::Fitting model to feature number 570, F597
## 2024-06-26 19:47:56.155885 INFO::Fitting model to feature number 571, F598
## 2024-06-26 19:47:56.160765 INFO::Fitting model to feature number 572, F599
## 2024-06-26 19:47:56.165718 INFO::Fitting model to feature number 573, F600
## 2024-06-26 19:47:56.170721 INFO::Fitting model to feature number 574, F601
## 2024-06-26 19:47:56.175873 INFO::Fitting model to feature number 575, F602
## 2024-06-26 19:47:56.181071 INFO::Fitting model to feature number 576, F603
## 2024-06-26 19:47:56.190933 INFO::Fitting model to feature number 577, F605
## 2024-06-26 19:47:56.199022 INFO::Fitting model to feature number 578, F606
## 2024-06-26 19:47:56.20563 INFO::Fitting model to feature number 579, F607
## 2024-06-26 19:47:56.210744 INFO::Fitting model to feature number 580, F608
## 2024-06-26 19:47:56.215742 INFO::Fitting model to feature number 581, F609
## 2024-06-26 19:47:56.220603 INFO::Fitting model to feature number 582, F610
## 2024-06-26 19:47:56.225874 INFO::Fitting model to feature number 583, F611
## 2024-06-26 19:47:56.231092 INFO::Fitting model to feature number 584, F612
## 2024-06-26 19:47:56.236211 INFO::Fitting model to feature number 585, F613
## 2024-06-26 19:47:56.2412 INFO::Fitting model to feature number 586, F614
## 2024-06-26 19:47:56.246315 INFO::Fitting model to feature number 587, F615
## 2024-06-26 19:47:56.251737 INFO::Fitting model to feature number 588, F616
## 2024-06-26 19:47:56.256589 INFO::Fitting model to feature number 589, F617
## 2024-06-26 19:47:56.261615 INFO::Fitting model to feature number 590, F618
## 2024-06-26 19:47:56.266498 INFO::Fitting model to feature number 591, F619
## 2024-06-26 19:47:56.271404 INFO::Fitting model to feature number 592, F620
## 2024-06-26 19:47:56.276402 INFO::Fitting model to feature number 593, F621
## 2024-06-26 19:47:56.28157 INFO::Fitting model to feature number 594, F622
## 2024-06-26 19:47:56.286631 INFO::Fitting model to feature number 595, F623
## 2024-06-26 19:47:56.291676 INFO::Fitting model to feature number 596, F624
## 2024-06-26 19:47:56.29682 INFO::Fitting model to feature number 597, F625
## 2024-06-26 19:47:56.302137 INFO::Fitting model to feature number 598, F626
## 2024-06-26 19:47:56.30782 INFO::Fitting model to feature number 599, F627
## 2024-06-26 19:47:56.313051 INFO::Fitting model to feature number 600, F628
## 2024-06-26 19:47:56.352309 INFO::Fitting model to feature number 601, F629
## 2024-06-26 19:47:56.360305 INFO::Fitting model to feature number 602, F630
## 2024-06-26 19:47:56.367924 INFO::Fitting model to feature number 603, F631
## 2024-06-26 19:47:56.375325 INFO::Fitting model to feature number 604, F632
## 2024-06-26 19:47:56.382739 INFO::Fitting model to feature number 605, F633
## 2024-06-26 19:47:56.39005 INFO::Fitting model to feature number 606, F634
## 2024-06-26 19:47:56.398549 INFO::Fitting model to feature number 607, F635
## 2024-06-26 19:47:56.406262 INFO::Fitting model to feature number 608, F636
## 2024-06-26 19:47:56.413665 INFO::Fitting model to feature number 609, F637
## 2024-06-26 19:47:56.421201 INFO::Fitting model to feature number 610, F638
## 2024-06-26 19:47:56.428673 INFO::Fitting model to feature number 611, F639
## 2024-06-26 19:47:56.436118 INFO::Fitting model to feature number 612, F640
## 2024-06-26 19:47:56.44356 INFO::Fitting model to feature number 613, F641
## 2024-06-26 19:47:56.451195 INFO::Fitting model to feature number 614, F642
## 2024-06-26 19:47:56.458718 INFO::Fitting model to feature number 615, F643
## 2024-06-26 19:47:56.466242 INFO::Fitting model to feature number 616, F644
## 2024-06-26 19:47:56.473887 INFO::Fitting model to feature number 617, F645
## 2024-06-26 19:47:56.481469 INFO::Fitting model to feature number 618, F646
## 2024-06-26 19:47:56.488989 INFO::Fitting model to feature number 619, F647
## 2024-06-26 19:47:56.496472 INFO::Fitting model to feature number 620, F648
## 2024-06-26 19:47:56.504091 INFO::Fitting model to feature number 621, F649
## 2024-06-26 19:47:56.511704 INFO::Fitting model to feature number 622, F650
## 2024-06-26 19:47:56.519152 INFO::Fitting model to feature number 623, F651
## 2024-06-26 19:47:56.526628 INFO::Fitting model to feature number 624, F652
## 2024-06-26 19:47:56.534089 INFO::Fitting model to feature number 625, F653
## 2024-06-26 19:47:56.541368 INFO::Fitting model to feature number 626, F654
## 2024-06-26 19:47:56.548829 INFO::Fitting model to feature number 627, F655
## 2024-06-26 19:47:56.556231 INFO::Fitting model to feature number 628, F656
## 2024-06-26 19:47:56.563937 INFO::Fitting model to feature number 629, F657
## 2024-06-26 19:47:56.571379 INFO::Fitting model to feature number 630, F658
## 2024-06-26 19:47:56.579021 INFO::Fitting model to feature number 631, F659
## 2024-06-26 19:47:56.586548 INFO::Fitting model to feature number 632, F660
## 2024-06-26 19:47:56.594005 INFO::Fitting model to feature number 633, F661
## 2024-06-26 19:47:56.601589 INFO::Fitting model to feature number 634, F662
## 2024-06-26 19:47:56.609621 INFO::Fitting model to feature number 635, F663
## 2024-06-26 19:47:56.617797 INFO::Fitting model to feature number 636, F664
## 2024-06-26 19:47:56.625795 INFO::Fitting model to feature number 637, F665
## 2024-06-26 19:47:56.633889 INFO::Fitting model to feature number 638, F666
## 2024-06-26 19:47:56.641973 INFO::Fitting model to feature number 639, F667
## 2024-06-26 19:47:56.650216 INFO::Fitting model to feature number 640, F668
## 2024-06-26 19:47:56.659183 INFO::Fitting model to feature number 641, F669
## 2024-06-26 19:47:56.66756 INFO::Fitting model to feature number 642, F670
## 2024-06-26 19:47:56.673405 INFO::Fitting model to feature number 643, F671
## 2024-06-26 19:47:56.678421 INFO::Fitting model to feature number 644, F672
## 2024-06-26 19:47:56.683395 INFO::Fitting model to feature number 645, F673
## 2024-06-26 19:47:56.690976 INFO::Fitting model to feature number 646, F674
## 2024-06-26 19:47:56.698148 INFO::Fitting model to feature number 647, F675
## 2024-06-26 19:47:56.705468 INFO::Fitting model to feature number 648, F676
## 2024-06-26 19:47:56.712853 INFO::Fitting model to feature number 649, F677
## 2024-06-26 19:47:56.720526 INFO::Fitting model to feature number 650, F678
## 2024-06-26 19:47:56.728182 INFO::Fitting model to feature number 651, F679
## 2024-06-26 19:47:56.735797 INFO::Fitting model to feature number 652, F680
## 2024-06-26 19:47:56.743315 INFO::Fitting model to feature number 653, F681
## 2024-06-26 19:47:56.751053 INFO::Fitting model to feature number 654, F682
## 2024-06-26 19:47:56.758751 INFO::Fitting model to feature number 655, F683
## 2024-06-26 19:47:56.767296 INFO::Fitting model to feature number 656, F684
## 2024-06-26 19:47:56.775464 INFO::Fitting model to feature number 657, F685
## 2024-06-26 19:47:56.783219 INFO::Fitting model to feature number 658, F686
## 2024-06-26 19:47:56.79761 INFO::Fitting model to feature number 659, F687
## 2024-06-26 19:47:56.80511 INFO::Fitting model to feature number 660, F688
## 2024-06-26 19:47:56.812731 INFO::Fitting model to feature number 661, F689
## 2024-06-26 19:47:56.820293 INFO::Fitting model to feature number 662, F690
## 2024-06-26 19:47:56.827938 INFO::Fitting model to feature number 663, F691
## 2024-06-26 19:47:56.835596 INFO::Fitting model to feature number 664, F692
## 2024-06-26 19:47:56.843354 INFO::Fitting model to feature number 665, F693
## 2024-06-26 19:47:56.850743 INFO::Fitting model to feature number 666, F694
## 2024-06-26 19:47:56.858307 INFO::Fitting model to feature number 667, F695
## 2024-06-26 19:47:56.8645 INFO::Fitting model to feature number 668, F696
## 2024-06-26 19:47:56.869314 INFO::Fitting model to feature number 669, F697
## 2024-06-26 19:47:56.874087 INFO::Fitting model to feature number 670, F698
## 2024-06-26 19:47:56.879009 INFO::Fitting model to feature number 671, F699
## 2024-06-26 19:47:56.883774 INFO::Fitting model to feature number 672, F700
## 2024-06-26 19:47:56.888549 INFO::Fitting model to feature number 673, F701
## 2024-06-26 19:47:56.893239 INFO::Fitting model to feature number 674, F702
## 2024-06-26 19:47:56.897854 INFO::Fitting model to feature number 675, F704
## 2024-06-26 19:47:56.902909 INFO::Fitting model to feature number 676, F705
## 2024-06-26 19:47:56.907582 INFO::Fitting model to feature number 677, F706
## 2024-06-26 19:47:56.913786 INFO::Fitting model to feature number 678, F707
## 2024-06-26 19:47:56.9209 INFO::Fitting model to feature number 679, F708
## 2024-06-26 19:47:56.927117 INFO::Fitting model to feature number 680, F709
## 2024-06-26 19:47:56.93197 INFO::Fitting model to feature number 681, F710
## 2024-06-26 19:47:56.937736 INFO::Fitting model to feature number 682, F711
## 2024-06-26 19:47:56.945089 INFO::Fitting model to feature number 683, F712
## 2024-06-26 19:47:56.952574 INFO::Fitting model to feature number 684, F713
## 2024-06-26 19:47:56.957461 INFO::Fitting model to feature number 685, F714
## 2024-06-26 19:47:56.962532 INFO::Fitting model to feature number 686, F715
## 2024-06-26 19:47:56.967342 INFO::Fitting model to feature number 687, F716
## 2024-06-26 19:47:56.972004 INFO::Fitting model to feature number 688, F717
## 2024-06-26 19:47:56.976662 INFO::Fitting model to feature number 689, F718
## 2024-06-26 19:47:56.982514 INFO::Fitting model to feature number 690, F719
## 2024-06-26 19:47:56.990057 INFO::Fitting model to feature number 691, F720
## 2024-06-26 19:47:56.997803 INFO::Fitting model to feature number 692, F721
## 2024-06-26 19:47:57.005645 INFO::Fitting model to feature number 693, F722
## 2024-06-26 19:47:57.013722 INFO::Fitting model to feature number 694, F723
## 2024-06-26 19:47:57.021208 INFO::Fitting model to feature number 695, F724
## 2024-06-26 19:47:57.02868 INFO::Fitting model to feature number 696, F725
## 2024-06-26 19:47:57.036229 INFO::Fitting model to feature number 697, F726
## 2024-06-26 19:47:57.043714 INFO::Fitting model to feature number 698, F727
## 2024-06-26 19:47:57.051127 INFO::Fitting model to feature number 699, F728
## 2024-06-26 19:47:57.058629 INFO::Fitting model to feature number 700, F729
## 2024-06-26 19:47:57.066337 INFO::Fitting model to feature number 701, F730
## 2024-06-26 19:47:57.074287 INFO::Fitting model to feature number 702, F731
## 2024-06-26 19:47:57.082153 INFO::Fitting model to feature number 703, F732
## 2024-06-26 19:47:57.08999 INFO::Fitting model to feature number 704, F733
## 2024-06-26 19:47:57.097863 INFO::Fitting model to feature number 705, F734
## 2024-06-26 19:47:57.105618 INFO::Fitting model to feature number 706, F735
## 2024-06-26 19:47:57.113288 INFO::Fitting model to feature number 707, F736
## 2024-06-26 19:47:57.120943 INFO::Fitting model to feature number 708, F737
## 2024-06-26 19:47:57.128556 INFO::Fitting model to feature number 709, F739
## 2024-06-26 19:47:57.136246 INFO::Fitting model to feature number 710, F740
## 2024-06-26 19:47:57.144102 INFO::Fitting model to feature number 711, F741
## 2024-06-26 19:47:57.151846 INFO::Fitting model to feature number 712, F742
## 2024-06-26 19:47:57.159601 INFO::Fitting model to feature number 713, F743
## 2024-06-26 19:47:57.167297 INFO::Fitting model to feature number 714, F744
## 2024-06-26 19:47:57.175108 INFO::Fitting model to feature number 715, F745
## 2024-06-26 19:47:57.182729 INFO::Fitting model to feature number 716, F746
## 2024-06-26 19:47:57.188737 INFO::Fitting model to feature number 717, F747
## 2024-06-26 19:47:57.193913 INFO::Fitting model to feature number 718, F748
## 2024-06-26 19:47:57.198729 INFO::Fitting model to feature number 719, F749
## 2024-06-26 19:47:57.203757 INFO::Fitting model to feature number 720, F750
## 2024-06-26 19:47:57.208724 INFO::Fitting model to feature number 721, F751
## 2024-06-26 19:47:57.213574 INFO::Fitting model to feature number 722, F752
## 2024-06-26 19:47:57.218438 INFO::Fitting model to feature number 723, F753
## 2024-06-26 19:47:57.223464 INFO::Fitting model to feature number 724, F754
## 2024-06-26 19:47:57.228282 INFO::Fitting model to feature number 725, F755
## 2024-06-26 19:47:57.233336 INFO::Fitting model to feature number 726, F756
## 2024-06-26 19:47:57.238196 INFO::Fitting model to feature number 727, F757
## 2024-06-26 19:47:57.242958 INFO::Fitting model to feature number 728, F758
## 2024-06-26 19:47:57.247779 INFO::Fitting model to feature number 729, F759
## 2024-06-26 19:47:57.253842 INFO::Fitting model to feature number 730, F760
## 2024-06-26 19:47:57.258664 INFO::Fitting model to feature number 731, F761
## 2024-06-26 19:47:57.263483 INFO::Fitting model to feature number 732, F762
## 2024-06-26 19:47:57.269022 INFO::Fitting model to feature number 733, F763
## 2024-06-26 19:47:57.273959 INFO::Fitting model to feature number 734, F764
## 2024-06-26 19:47:57.281398 INFO::Fitting model to feature number 735, F765
## 2024-06-26 19:47:57.289049 INFO::Fitting model to feature number 736, F766
## 2024-06-26 19:47:57.293998 INFO::Fitting model to feature number 737, F767
## 2024-06-26 19:47:57.298994 INFO::Fitting model to feature number 738, F768
## 2024-06-26 19:47:57.303967 INFO::Fitting model to feature number 739, F769
## 2024-06-26 19:47:57.30879 INFO::Fitting model to feature number 740, F770
## 2024-06-26 19:47:57.313702 INFO::Fitting model to feature number 741, F771
## 2024-06-26 19:47:57.320386 INFO::Fitting model to feature number 742, F772
## 2024-06-26 19:47:57.328776 INFO::Fitting model to feature number 743, F773
## 2024-06-26 19:47:57.334408 INFO::Fitting model to feature number 744, F774
## 2024-06-26 19:47:57.340926 INFO::Fitting model to feature number 745, F775
## 2024-06-26 19:47:57.349174 INFO::Fitting model to feature number 746, F776
## 2024-06-26 19:47:57.355744 INFO::Fitting model to feature number 747, F777
## 2024-06-26 19:47:57.363559 INFO::Fitting model to feature number 748, F778
## 2024-06-26 19:47:57.371594 INFO::Fitting model to feature number 749, F779
## 2024-06-26 19:47:57.380746 INFO::Fitting model to feature number 750, F780
## 2024-06-26 19:47:57.388859 INFO::Fitting model to feature number 751, F781
## 2024-06-26 19:47:57.396869 INFO::Fitting model to feature number 752, F782
## 2024-06-26 19:47:57.404386 INFO::Fitting model to feature number 753, F783
## 2024-06-26 19:47:57.412145 INFO::Fitting model to feature number 754, F784
## 2024-06-26 19:47:57.419694 INFO::Fitting model to feature number 755, F785
## 2024-06-26 19:47:57.427656 INFO::Fitting model to feature number 756, F786
## 2024-06-26 19:47:57.436416 INFO::Fitting model to feature number 757, F787
## 2024-06-26 19:47:57.446062 INFO::Fitting model to feature number 758, F788
## 2024-06-26 19:47:57.454273 INFO::Fitting model to feature number 759, F789
## 2024-06-26 19:47:57.462389 INFO::Fitting model to feature number 760, F790
## 2024-06-26 19:47:57.470619 INFO::Fitting model to feature number 761, F791
## 2024-06-26 19:47:57.478759 INFO::Fitting model to feature number 762, F792
## 2024-06-26 19:47:57.486887 INFO::Fitting model to feature number 763, F793
## 2024-06-26 19:47:57.497316 INFO::Fitting model to feature number 764, F794
## 2024-06-26 19:47:57.505415 INFO::Fitting model to feature number 765, F795
## 2024-06-26 19:47:57.513774 INFO::Fitting model to feature number 766, F796
## 2024-06-26 19:47:57.521698 INFO::Fitting model to feature number 767, F797
## 2024-06-26 19:47:57.529758 INFO::Fitting model to feature number 768, F798
## 2024-06-26 19:47:57.538193 INFO::Fitting model to feature number 769, F799
## 2024-06-26 19:47:57.54626 INFO::Fitting model to feature number 770, F800
## 2024-06-26 19:47:57.554566 INFO::Fitting model to feature number 771, F801
## 2024-06-26 19:47:57.56253 INFO::Fitting model to feature number 772, F802
## 2024-06-26 19:47:57.570549 INFO::Fitting model to feature number 773, F803
## 2024-06-26 19:47:57.578672 INFO::Fitting model to feature number 774, F804
## 2024-06-26 19:47:57.586712 INFO::Fitting model to feature number 775, F805
## 2024-06-26 19:47:57.594421 INFO::Fitting model to feature number 776, F806
## 2024-06-26 19:47:57.602294 INFO::Fitting model to feature number 777, F808
## 2024-06-26 19:47:57.610445 INFO::Fitting model to feature number 778, F809
## 2024-06-26 19:47:57.631811 INFO::Fitting model to feature number 779, F810
## 2024-06-26 19:47:57.637251 INFO::Fitting model to feature number 780, F811
## 2024-06-26 19:47:57.642742 INFO::Fitting model to feature number 781, F812
## 2024-06-26 19:47:57.648117 INFO::Fitting model to feature number 782, F813
## 2024-06-26 19:47:57.653515 INFO::Fitting model to feature number 783, F814
## 2024-06-26 19:47:57.658982 INFO::Fitting model to feature number 784, F815
## 2024-06-26 19:47:57.664313 INFO::Fitting model to feature number 785, F816
## 2024-06-26 19:47:57.669382 INFO::Fitting model to feature number 786, F817
## 2024-06-26 19:47:57.674223 INFO::Fitting model to feature number 787, F818
## 2024-06-26 19:47:57.679276 INFO::Fitting model to feature number 788, F819
## 2024-06-26 19:47:57.684194 INFO::Fitting model to feature number 789, F820
## 2024-06-26 19:47:57.689483 INFO::Fitting model to feature number 790, F821
## 2024-06-26 19:47:57.69484 INFO::Fitting model to feature number 791, F822
## 2024-06-26 19:47:57.699929 INFO::Fitting model to feature number 792, F823
## 2024-06-26 19:47:57.704884 INFO::Fitting model to feature number 793, F824
## 2024-06-26 19:47:57.711187 INFO::Fitting model to feature number 794, F825
## 2024-06-26 19:47:57.717509 INFO::Fitting model to feature number 795, F826
## 2024-06-26 19:47:57.723031 INFO::Fitting model to feature number 796, F827
## 2024-06-26 19:47:57.728299 INFO::Fitting model to feature number 797, F828
## 2024-06-26 19:47:57.733511 INFO::Fitting model to feature number 798, F829
## 2024-06-26 19:47:57.739049 INFO::Fitting model to feature number 799, F830
## 2024-06-26 19:47:57.744817 INFO::Fitting model to feature number 800, F831
## 2024-06-26 19:47:57.750035 INFO::Fitting model to feature number 801, F832
## 2024-06-26 19:47:57.755248 INFO::Fitting model to feature number 802, F833
## 2024-06-26 19:47:57.760562 INFO::Fitting model to feature number 803, F834
## 2024-06-26 19:47:57.765735 INFO::Fitting model to feature number 804, F835
## 2024-06-26 19:47:57.771166 INFO::Fitting model to feature number 805, F836
## 2024-06-26 19:47:57.776181 INFO::Fitting model to feature number 806, F837
## 2024-06-26 19:47:57.782611 INFO::Fitting model to feature number 807, F838
## 2024-06-26 19:47:57.790264 INFO::Fitting model to feature number 808, F839
## 2024-06-26 19:47:57.796927 INFO::Fitting model to feature number 809, F840
## 2024-06-26 19:47:57.802491 INFO::Fitting model to feature number 810, F841
## 2024-06-26 19:47:57.80811 INFO::Fitting model to feature number 811, F842
## 2024-06-26 19:47:57.813337 INFO::Fitting model to feature number 812, F843
## 2024-06-26 19:47:57.819119 INFO::Fitting model to feature number 813, F844
## 2024-06-26 19:47:57.824354 INFO::Fitting model to feature number 814, F845
## 2024-06-26 19:47:57.829463 INFO::Fitting model to feature number 815, F846
## 2024-06-26 19:47:57.834715 INFO::Fitting model to feature number 816, F847
## 2024-06-26 19:47:57.84007 INFO::Fitting model to feature number 817, F848
## 2024-06-26 19:47:57.845176 INFO::Fitting model to feature number 818, F849
## 2024-06-26 19:47:57.850496 INFO::Fitting model to feature number 819, F850
## 2024-06-26 19:47:57.855681 INFO::Fitting model to feature number 820, F851
## 2024-06-26 19:47:57.861052 INFO::Fitting model to feature number 821, F852
## 2024-06-26 19:47:57.86703 INFO::Fitting model to feature number 822, F853
## 2024-06-26 19:47:57.872542 INFO::Fitting model to feature number 823, F854
## 2024-06-26 19:47:57.877994 INFO::Fitting model to feature number 824, F855
## 2024-06-26 19:47:57.883211 INFO::Fitting model to feature number 825, F856
## 2024-06-26 19:47:57.888236 INFO::Fitting model to feature number 826, F857
## 2024-06-26 19:47:57.893411 INFO::Fitting model to feature number 827, F858
## 2024-06-26 19:47:57.898429 INFO::Fitting model to feature number 828, F859
## 2024-06-26 19:47:57.903565 INFO::Fitting model to feature number 829, F860
## 2024-06-26 19:47:57.910877 INFO::Fitting model to feature number 830, F861
## 2024-06-26 19:47:57.919017 INFO::Fitting model to feature number 831, F862
## 2024-06-26 19:47:57.927226 INFO::Fitting model to feature number 832, F863
## 2024-06-26 19:47:57.934076 INFO::Fitting model to feature number 833, F864
## 2024-06-26 19:47:57.940576 INFO::Fitting model to feature number 834, F865
## 2024-06-26 19:47:57.948535 INFO::Fitting model to feature number 835, F866
## 2024-06-26 19:47:57.956896 INFO::Fitting model to feature number 836, F867
## 2024-06-26 19:47:57.964616 INFO::Fitting model to feature number 837, F868
## 2024-06-26 19:47:57.972519 INFO::Fitting model to feature number 838, F869
## 2024-06-26 19:47:57.980737 INFO::Fitting model to feature number 839, F870
## 2024-06-26 19:47:57.988716 INFO::Fitting model to feature number 840, F871
## 2024-06-26 19:47:57.996682 INFO::Fitting model to feature number 841, F872
## 2024-06-26 19:47:58.004603 INFO::Fitting model to feature number 842, F873
## 2024-06-26 19:47:58.013175 INFO::Fitting model to feature number 843, F874
## 2024-06-26 19:47:58.021251 INFO::Fitting model to feature number 844, F875
## 2024-06-26 19:47:58.029293 INFO::Fitting model to feature number 845, F876
## 2024-06-26 19:47:58.037535 INFO::Fitting model to feature number 846, F877
## 2024-06-26 19:47:58.045999 INFO::Fitting model to feature number 847, F878
## 2024-06-26 19:47:58.054805 INFO::Fitting model to feature number 848, F879
## 2024-06-26 19:47:58.063578 INFO::Fitting model to feature number 849, F880
## 2024-06-26 19:47:58.072367 INFO::Fitting model to feature number 850, F881
## 2024-06-26 19:47:58.080702 INFO::Fitting model to feature number 851, F882
## 2024-06-26 19:47:58.088663 INFO::Fitting model to feature number 852, F883
## 2024-06-26 19:47:58.096321 INFO::Fitting model to feature number 853, F884
## 2024-06-26 19:47:58.104191 INFO::Fitting model to feature number 854, F885
## 2024-06-26 19:47:58.112111 INFO::Fitting model to feature number 855, F886
## 2024-06-26 19:47:58.119984 INFO::Fitting model to feature number 856, F887
## 2024-06-26 19:47:58.127936 INFO::Fitting model to feature number 857, F888
## 2024-06-26 19:47:58.136398 INFO::Fitting model to feature number 858, F889
## 2024-06-26 19:47:58.143109 INFO::Fitting model to feature number 859, F890
## 2024-06-26 19:47:58.148654 INFO::Fitting model to feature number 860, F891
## 2024-06-26 19:47:58.153905 INFO::Fitting model to feature number 861, F892
## 2024-06-26 19:47:58.159299 INFO::Fitting model to feature number 862, F893
## 2024-06-26 19:47:58.164683 INFO::Fitting model to feature number 863, F894
## 2024-06-26 19:47:58.169794 INFO::Fitting model to feature number 864, F895
## 2024-06-26 19:47:58.17507 INFO::Fitting model to feature number 865, F896
## 2024-06-26 19:47:58.180324 INFO::Fitting model to feature number 866, F897
## 2024-06-26 19:47:58.186187 INFO::Fitting model to feature number 867, F898
## 2024-06-26 19:47:58.19117 INFO::Fitting model to feature number 868, F899
## 2024-06-26 19:47:58.196153 INFO::Fitting model to feature number 869, F900
## 2024-06-26 19:47:58.385964 INFO::Counting total values for each feature
## 2024-06-26 19:47:58.568608 INFO::Writing filtered data to file Macarron_output/maaslin2_results/features/filtered_data.tsv
## 2024-06-26 19:47:58.933197 INFO::Writing filtered, normalized data to file Macarron_output/maaslin2_results/features/filtered_data_norm.tsv
## 2024-06-26 19:47:59.219309 INFO::Writing filtered, normalized, transformed data to file Macarron_output/maaslin2_results/features/filtered_data_norm_transformed.tsv
## 2024-06-26 19:47:59.665384 INFO::Writing residuals to file Macarron_output/maaslin2_results/fits/residuals.rds
## 2024-06-26 19:47:59.718727 INFO::Writing fitted values to file Macarron_output/maaslin2_results/fits/fitted.rds
## 2024-06-26 19:48:00.033105 INFO::Writing all results to file (ordered by increasing q-values): Macarron_output/maaslin2_results/all_results.tsv
## 2024-06-26 19:48:00.129852 INFO::Writing the significant results (those which are less than or equal to the threshold of 0.250000 ) to file (ordered by increasing q-values): Macarron_output/maaslin2_results/significant_results.tsv
## 2024-06-26 19:48:00.170692 INFO::Writing association plots (one for each significant association) to output folder: Macarron_output/maaslin2_results
## 2024-06-26 19:48:00.202293 INFO::Plotting associations from most to least significant, grouped by metadata
## 2024-06-26 19:48:00.205637 INFO::Plotting data for metadata number 1, diagnosis
## 2024-06-26 19:48:00.275742 INFO::Creating boxplot for categorical data, diagnosis vs F504
## 2024-06-26 19:48:00.65912 INFO::Creating boxplot for categorical data, diagnosis vs F859
## 2024-06-26 19:48:00.995987 INFO::Creating boxplot for categorical data, diagnosis vs F533
## 2024-06-26 19:48:01.203254 INFO::Creating boxplot for categorical data, diagnosis vs F587
## 2024-06-26 19:48:01.385971 INFO::Creating boxplot for categorical data, diagnosis vs F584
## 2024-06-26 19:48:01.580293 INFO::Creating boxplot for categorical data, diagnosis vs F197
## 2024-06-26 19:48:01.755875 INFO::Creating boxplot for categorical data, diagnosis vs F380
## 2024-06-26 19:48:01.982836 INFO::Creating boxplot for categorical data, diagnosis vs F829
## 2024-06-26 19:48:02.24613 INFO::Creating boxplot for categorical data, diagnosis vs F664
## 2024-06-26 19:48:02.447384 INFO::Creating boxplot for categorical data, diagnosis vs F93
## 2024-06-26 19:48:02.731138 INFO::Creating boxplot for categorical data, diagnosis vs F15
## 2024-06-26 19:48:03.019113 INFO::Creating boxplot for categorical data, diagnosis vs F881
## 2024-06-26 19:48:03.226557 INFO::Creating boxplot for categorical data, diagnosis vs F806
## 2024-06-26 19:48:03.410828 INFO::Creating boxplot for categorical data, diagnosis vs F78
## 2024-06-26 19:48:03.585774 INFO::Creating boxplot for categorical data, diagnosis vs F189
## 2024-06-26 19:48:03.757921 INFO::Creating boxplot for categorical data, diagnosis vs F369
## 2024-06-26 19:48:03.945391 INFO::Creating boxplot for categorical data, diagnosis vs F623
## 2024-06-26 19:48:04.133332 INFO::Creating boxplot for categorical data, diagnosis vs F710
## 2024-06-26 19:48:04.326476 INFO::Creating boxplot for categorical data, diagnosis vs F851
## 2024-06-26 19:48:04.508537 INFO::Creating boxplot for categorical data, diagnosis vs F257
## 2024-06-26 19:48:04.700819 INFO::Creating boxplot for categorical data, diagnosis vs F330
## 2024-06-26 19:48:04.910994 INFO::Creating boxplot for categorical data, diagnosis vs F344
## 2024-06-26 19:48:05.206017 INFO::Creating boxplot for categorical data, diagnosis vs F696
## 2024-06-26 19:48:05.38846 INFO::Creating boxplot for categorical data, diagnosis vs F741
## 2024-06-26 19:48:05.579266 INFO::Creating boxplot for categorical data, diagnosis vs F509
## 2024-06-26 19:48:05.765132 INFO::Creating boxplot for categorical data, diagnosis vs F479
## 2024-06-26 19:48:06.030702 INFO::Creating boxplot for categorical data, diagnosis vs F550
## 2024-06-26 19:48:06.318327 INFO::Creating boxplot for categorical data, diagnosis vs F640
## 2024-06-26 19:48:06.608597 INFO::Creating boxplot for categorical data, diagnosis vs F281
## 2024-06-26 19:48:06.880124 INFO::Creating boxplot for categorical data, diagnosis vs F80
## 2024-06-26 19:48:07.135235 INFO::Creating boxplot for categorical data, diagnosis vs F285
## 2024-06-26 19:48:07.387973 INFO::Creating boxplot for categorical data, diagnosis vs F531
## 2024-06-26 19:48:07.650577 INFO::Creating boxplot for categorical data, diagnosis vs F737
## 2024-06-26 19:48:07.852751 INFO::Creating boxplot for categorical data, diagnosis vs F875
## 2024-06-26 19:48:08.06503 INFO::Creating boxplot for categorical data, diagnosis vs F864
## 2024-06-26 19:48:08.342742 INFO::Creating boxplot for categorical data, diagnosis vs F379
## 2024-06-26 19:48:08.621956 INFO::Creating boxplot for categorical data, diagnosis vs F190
## 2024-06-26 19:48:08.91495 INFO::Creating boxplot for categorical data, diagnosis vs F4
## 2024-06-26 19:48:09.175482 INFO::Creating boxplot for categorical data, diagnosis vs F591
## 2024-06-26 19:48:09.368463 INFO::Creating boxplot for categorical data, diagnosis vs F773
## 2024-06-26 19:48:09.534951 INFO::Creating boxplot for categorical data, diagnosis vs F283
## 2024-06-26 19:48:09.802359 INFO::Creating boxplot for categorical data, diagnosis vs F233
## 2024-06-26 19:48:09.998575 INFO::Creating boxplot for categorical data, diagnosis vs F420
## 2024-06-26 19:48:10.223882 INFO::Creating boxplot for categorical data, diagnosis vs F5
## 2024-06-26 19:48:10.44598 INFO::Creating boxplot for categorical data, diagnosis vs F137
## 2024-06-26 19:48:10.642421 INFO::Creating boxplot for categorical data, diagnosis vs F215
## 2024-06-26 19:48:10.825108 INFO::Creating boxplot for categorical data, diagnosis vs F489
## 2024-06-26 19:48:11.075061 INFO::Creating boxplot for categorical data, diagnosis vs F220
## 2024-06-26 19:48:11.268564 INFO::Creating boxplot for categorical data, diagnosis vs F691
## 2024-06-26 19:48:11.470097 INFO::Creating boxplot for categorical data, diagnosis vs F381
## 2024-06-26 19:48:11.672015 INFO::Creating boxplot for categorical data, diagnosis vs F539
## 2024-06-26 19:48:11.849244 INFO::Creating boxplot for categorical data, diagnosis vs F490
## 2024-06-26 19:48:12.019657 INFO::Creating boxplot for categorical data, diagnosis vs F832
## 2024-06-26 19:48:12.260281 INFO::Creating boxplot for categorical data, diagnosis vs F396
## 2024-06-26 19:48:12.531129 INFO::Creating boxplot for categorical data, diagnosis vs F528
## 2024-06-26 19:48:12.803966 INFO::Creating boxplot for categorical data, diagnosis vs F234
## 2024-06-26 19:48:13.009778 INFO::Creating boxplot for categorical data, diagnosis vs F178
## 2024-06-26 19:48:13.191073 INFO::Creating boxplot for categorical data, diagnosis vs F761
## 2024-06-26 19:48:13.464044 INFO::Creating boxplot for categorical data, diagnosis vs F2
## 2024-06-26 19:48:13.683262 INFO::Creating boxplot for categorical data, diagnosis vs F260
## 2024-06-26 19:48:13.869181 INFO::Creating boxplot for categorical data, diagnosis vs F734
## 2024-06-26 19:48:14.142355 INFO::Creating boxplot for categorical data, diagnosis vs F429
## 2024-06-26 19:48:14.333883 INFO::Creating boxplot for categorical data, diagnosis vs F630
## 2024-06-26 19:48:14.541637 INFO::Creating boxplot for categorical data, diagnosis vs F817
## 2024-06-26 19:48:14.825002 INFO::Creating boxplot for categorical data, diagnosis vs F847
## 2024-06-26 19:48:15.110429 INFO::Creating boxplot for categorical data, diagnosis vs F896
## 2024-06-26 19:48:15.291009 INFO::Creating boxplot for categorical data, diagnosis vs F81
## 2024-06-26 19:48:15.488573 INFO::Creating boxplot for categorical data, diagnosis vs F110
## 2024-06-26 19:48:15.65559 INFO::Creating boxplot for categorical data, diagnosis vs F3
## 2024-06-26 19:48:15.824957 INFO::Creating boxplot for categorical data, diagnosis vs F33
## 2024-06-26 19:48:15.998671 INFO::Creating boxplot for categorical data, diagnosis vs F270
## 2024-06-26 19:48:16.448205 INFO::Creating boxplot for categorical data, diagnosis vs F278
## 2024-06-26 19:48:16.634693 INFO::Creating boxplot for categorical data, diagnosis vs F264
## 2024-06-26 19:48:16.869327 INFO::Creating boxplot for categorical data, diagnosis vs F90
## 2024-06-26 19:48:17.092657 INFO::Creating boxplot for categorical data, diagnosis vs F403
## 2024-06-26 19:48:17.314173 INFO::Creating boxplot for categorical data, diagnosis vs F727
## 2024-06-26 19:48:17.487257 INFO::Creating boxplot for categorical data, diagnosis vs F394
## 2024-06-26 19:48:17.668349 INFO::Creating boxplot for categorical data, diagnosis vs F800
## 2024-06-26 19:48:17.851227 INFO::Creating boxplot for categorical data, diagnosis vs F439
## 2024-06-26 19:48:18.028096 INFO::Creating boxplot for categorical data, diagnosis vs F554
## 2024-06-26 19:48:18.209439 INFO::Creating boxplot for categorical data, diagnosis vs F559
## 2024-06-26 19:48:18.376997 INFO::Creating boxplot for categorical data, diagnosis vs F548
## 2024-06-26 19:48:18.648768 INFO::Creating boxplot for categorical data, diagnosis vs F794
## 2024-06-26 19:48:18.93461 INFO::Creating boxplot for categorical data, diagnosis vs F45
## 2024-06-26 19:48:19.180817 INFO::Creating boxplot for categorical data, diagnosis vs F158
## 2024-06-26 19:48:19.457954 INFO::Creating boxplot for categorical data, diagnosis vs F477
## 2024-06-26 19:48:19.636718 INFO::Creating boxplot for categorical data, diagnosis vs F1
## 2024-06-26 19:48:19.801479 INFO::Creating boxplot for categorical data, diagnosis vs F862
## 2024-06-26 19:48:20.055736 INFO::Creating boxplot for categorical data, diagnosis vs F803
## 2024-06-26 19:48:20.283886 INFO::Creating boxplot for categorical data, diagnosis vs F751
## 2024-06-26 19:48:20.568167 INFO::Creating boxplot for categorical data, diagnosis vs F98
## 2024-06-26 19:48:20.854397 INFO::Creating boxplot for categorical data, diagnosis vs F22
## 2024-06-26 19:48:21.13568 INFO::Creating boxplot for categorical data, diagnosis vs F625
## 2024-06-26 19:48:21.34258 INFO::Creating boxplot for categorical data, diagnosis vs F206
## 2024-06-26 19:48:21.551593 INFO::Creating boxplot for categorical data, diagnosis vs F779
## 2024-06-26 19:48:22.025623 INFO::Creating boxplot for categorical data, diagnosis vs F532
## 2024-06-26 19:48:22.344947 INFO::Creating boxplot for categorical data, diagnosis vs F676
## 2024-06-26 19:48:22.584278 INFO::Creating boxplot for categorical data, diagnosis vs F644
## 2024-06-26 19:48:22.798015 INFO::Creating boxplot for categorical data, diagnosis vs F7
## 2024-06-26 19:48:23.006761 INFO::Creating boxplot for categorical data, diagnosis vs F596
## 2024-06-26 19:48:23.284446 INFO::Creating boxplot for categorical data, diagnosis vs F250
## 2024-06-26 19:48:23.528492 INFO::Creating boxplot for categorical data, diagnosis vs F462
## 2024-06-26 19:48:23.701227 INFO::Creating boxplot for categorical data, diagnosis vs F516
## 2024-06-26 19:48:23.878755 INFO::Creating boxplot for categorical data, diagnosis vs F659
## 2024-06-26 19:48:24.053783 INFO::Creating boxplot for categorical data, diagnosis vs F663
## 2024-06-26 19:48:24.222653 INFO::Creating boxplot for categorical data, diagnosis vs F837
## 2024-06-26 19:48:24.410955 INFO::Creating boxplot for categorical data, diagnosis vs F138
## 2024-06-26 19:48:24.672921 INFO::Creating boxplot for categorical data, diagnosis vs F445
## 2024-06-26 19:48:24.896861 INFO::Creating boxplot for categorical data, diagnosis vs F697
## 2024-06-26 19:48:25.075793 INFO::Creating boxplot for categorical data, diagnosis vs F225
## 2024-06-26 19:48:25.249928 INFO::Creating boxplot for categorical data, diagnosis vs F148
## 2024-06-26 19:48:25.497515 INFO::Creating boxplot for categorical data, diagnosis vs F448
## 2024-06-26 19:48:25.703986 INFO::Creating boxplot for categorical data, diagnosis vs F91
## 2024-06-26 19:48:25.913041 INFO::Creating boxplot for categorical data, diagnosis vs F123
## 2024-06-26 19:48:26.169109 INFO::Creating boxplot for categorical data, diagnosis vs F665
## 2024-06-26 19:48:26.390193 INFO::Creating boxplot for categorical data, diagnosis vs F845
## 2024-06-26 19:48:26.636423 INFO::Creating boxplot for categorical data, diagnosis vs F331
## 2024-06-26 19:48:26.923814 INFO::Creating boxplot for categorical data, diagnosis vs F361
## 2024-06-26 19:48:27.105988 INFO::Creating boxplot for categorical data, diagnosis vs F421
## 2024-06-26 19:48:27.337275 INFO::Creating boxplot for categorical data, diagnosis vs F277
## 2024-06-26 19:48:27.52637 INFO::Creating boxplot for categorical data, diagnosis vs F307
## 2024-06-26 19:48:27.729073 INFO::Creating boxplot for categorical data, diagnosis vs F503
## 2024-06-26 19:48:27.928148 INFO::Creating boxplot for categorical data, diagnosis vs F34
## 2024-06-26 19:48:28.176582 INFO::Creating boxplot for categorical data, diagnosis vs F649
## 2024-06-26 19:48:28.458192 INFO::Creating boxplot for categorical data, diagnosis vs F825
## 2024-06-26 19:48:28.745082 INFO::Creating boxplot for categorical data, diagnosis vs F298
## 2024-06-26 19:48:29.011038 INFO::Creating boxplot for categorical data, diagnosis vs F461
## 2024-06-26 19:48:29.273092 INFO::Creating boxplot for categorical data, diagnosis vs F242
## 2024-06-26 19:48:29.470734 INFO::Creating boxplot for categorical data, diagnosis vs F375
## 2024-06-26 19:48:29.663291 INFO::Creating boxplot for categorical data, diagnosis vs F648
## 2024-06-26 19:48:29.832986 INFO::Creating boxplot for categorical data, diagnosis vs F724
## 2024-06-26 19:48:29.998263 INFO::Creating boxplot for categorical data, diagnosis vs F678
## 2024-06-26 19:48:30.185181 INFO::Creating boxplot for categorical data, diagnosis vs F290
## 2024-06-26 19:48:30.399326 INFO::Creating boxplot for categorical data, diagnosis vs F743
## 2024-06-26 19:48:30.655359 INFO::Creating boxplot for categorical data, diagnosis vs F495
## 2024-06-26 19:48:30.827107 INFO::Creating boxplot for categorical data, diagnosis vs F261
## 2024-06-26 19:48:31.019029 INFO::Creating boxplot for categorical data, diagnosis vs F43
## 2024-06-26 19:48:31.249393 INFO::Creating boxplot for categorical data, diagnosis vs F714
## 2024-06-26 19:48:31.486797 INFO::Creating boxplot for categorical data, diagnosis vs F131
## 2024-06-26 19:48:31.76126 INFO::Creating boxplot for categorical data, diagnosis vs F150
## 2024-06-26 19:48:31.990213 INFO::Creating boxplot for categorical data, diagnosis vs F651
## 2024-06-26 19:48:32.243681 INFO::Creating boxplot for categorical data, diagnosis vs F798
## 2024-06-26 19:48:32.487178 INFO::Creating boxplot for categorical data, diagnosis vs F289
## 2024-06-26 19:48:32.698567 INFO::Creating boxplot for categorical data, diagnosis vs F661
## 2024-06-26 19:48:32.889381 INFO::Creating boxplot for categorical data, diagnosis vs F199
## 2024-06-26 19:48:33.145539 INFO::Creating boxplot for categorical data, diagnosis vs F406
## 2024-06-26 19:48:33.330315 INFO::Creating boxplot for categorical data, diagnosis vs F139
## 2024-06-26 19:48:33.552357 INFO::Creating boxplot for categorical data, diagnosis vs F506
## 2024-06-26 19:48:33.811324 INFO::Creating boxplot for categorical data, diagnosis vs F552
## 2024-06-26 19:48:34.022698 INFO::Creating boxplot for categorical data, diagnosis vs F94
## 2024-06-26 19:48:34.208575 INFO::Creating boxplot for categorical data, diagnosis vs F430
## 2024-06-26 19:48:34.496468 INFO::Creating boxplot for categorical data, diagnosis vs F639
## 2024-06-26 19:48:34.770345 INFO::Creating boxplot for categorical data, diagnosis vs F500
## 2024-06-26 19:48:35.075313 INFO::Creating boxplot for categorical data, diagnosis vs F609
## 2024-06-26 19:48:35.338736 INFO::Creating boxplot for categorical data, diagnosis vs F306
## 2024-06-26 19:48:35.537144 INFO::Creating boxplot for categorical data, diagnosis vs F507
## 2024-06-26 19:48:35.743929 INFO::Creating boxplot for categorical data, diagnosis vs F671
## 2024-06-26 19:48:35.986952 INFO::Creating boxplot for categorical data, diagnosis vs F894
## 2024-06-26 19:48:36.249063 INFO::Creating boxplot for categorical data, diagnosis vs F345
## 2024-06-26 19:48:36.502041 INFO::Creating boxplot for categorical data, diagnosis vs F801
## 2024-06-26 19:48:36.669854 INFO::Creating boxplot for categorical data, diagnosis vs F194
## 2024-06-26 19:48:36.858979 INFO::Creating boxplot for categorical data, diagnosis vs F195
## 2024-06-26 19:48:37.094809 INFO::Creating boxplot for categorical data, diagnosis vs F119
## 2024-06-26 19:48:37.307672 INFO::Creating boxplot for categorical data, diagnosis vs F120
## 2024-06-26 19:48:37.604666 INFO::Creating boxplot for categorical data, diagnosis vs F231
## 2024-06-26 19:48:37.868687 INFO::Creating boxplot for categorical data, diagnosis vs F311
## 2024-06-26 19:48:38.039185 INFO::Creating boxplot for categorical data, diagnosis vs F646
## 2024-06-26 19:48:38.225296 INFO::Creating boxplot for categorical data, diagnosis vs F814
## 2024-06-26 19:48:38.431996 INFO::Creating boxplot for categorical data, diagnosis vs F510
## 2024-06-26 19:48:38.708656 INFO::Creating boxplot for categorical data, diagnosis vs F398
## 2024-06-26 19:48:39.004358 INFO::Creating boxplot for categorical data, diagnosis vs F60
## 2024-06-26 19:48:39.235068 INFO::Creating boxplot for categorical data, diagnosis vs F153
## 2024-06-26 19:48:39.413407 INFO::Creating boxplot for categorical data, diagnosis vs F858
## 2024-06-26 19:48:39.64606 INFO::Creating boxplot for categorical data, diagnosis vs F775
## 2024-06-26 19:48:39.824859 INFO::Creating boxplot for categorical data, diagnosis vs F684
## 2024-06-26 19:48:40.014913 INFO::Creating boxplot for categorical data, diagnosis vs F384
## 2024-06-26 19:48:40.240276 INFO::Creating boxplot for categorical data, diagnosis vs F134
## 2024-06-26 19:48:40.522354 INFO::Creating boxplot for categorical data, diagnosis vs F670
## 2024-06-26 19:48:40.741053 INFO::Creating boxplot for categorical data, diagnosis vs F632
## 2024-06-26 19:48:40.989085 INFO::Creating boxplot for categorical data, diagnosis vs F721
## 2024-06-26 19:48:41.199936 INFO::Creating boxplot for categorical data, diagnosis vs F700
## 2024-06-26 19:48:41.405708 INFO::Creating boxplot for categorical data, diagnosis vs F376
## 2024-06-26 19:48:41.584647 INFO::Creating boxplot for categorical data, diagnosis vs F301
## 2024-06-26 19:48:41.786425 INFO::Creating boxplot for categorical data, diagnosis vs F27
## 2024-06-26 19:48:42.08396 INFO::Creating boxplot for categorical data, diagnosis vs F280
## 2024-06-26 19:48:42.263872 INFO::Creating boxplot for categorical data, diagnosis vs F391
## 2024-06-26 19:48:42.430948 INFO::Creating boxplot for categorical data, diagnosis vs F725
## 2024-06-26 19:48:42.612743 INFO::Creating boxplot for categorical data, diagnosis vs F186
## 2024-06-26 19:48:42.785441 INFO::Creating boxplot for categorical data, diagnosis vs F481
## 2024-06-26 19:48:43.047468 INFO::Creating boxplot for categorical data, diagnosis vs F333
## 2024-06-26 19:48:43.358772 INFO::Creating boxplot for categorical data, diagnosis vs F720
## 2024-06-26 19:48:43.600368 INFO::Creating boxplot for categorical data, diagnosis vs F520
## 2024-06-26 19:48:43.801521 INFO::Creating boxplot for categorical data, diagnosis vs F129
## 2024-06-26 19:48:43.98803 INFO::Creating boxplot for categorical data, diagnosis vs F204
## 2024-06-26 19:48:44.170415 INFO::Creating boxplot for categorical data, diagnosis vs F259
## 2024-06-26 19:48:44.359808 INFO::Creating boxplot for categorical data, diagnosis vs F831
## 2024-06-26 19:48:44.575908 INFO::Creating boxplot for categorical data, diagnosis vs F891
## 2024-06-26 19:48:44.763701 INFO::Creating boxplot for categorical data, diagnosis vs F262
## 2024-06-26 19:48:44.941316 INFO::Creating boxplot for categorical data, diagnosis vs F592
## 2024-06-26 19:48:45.157333 INFO::Creating boxplot for categorical data, diagnosis vs F343
## 2024-06-26 19:48:45.359523 INFO::Creating boxplot for categorical data, diagnosis vs F505
## 2024-06-26 19:48:45.667495 INFO::Creating boxplot for categorical data, diagnosis vs F622
## 2024-06-26 19:48:45.85647 INFO::Creating boxplot for categorical data, diagnosis vs F348
## 2024-06-26 19:48:46.106192 INFO::Creating boxplot for categorical data, diagnosis vs F133
## 2024-06-26 19:48:46.369292 INFO::Creating boxplot for categorical data, diagnosis vs F371
## 2024-06-26 19:48:46.648377 INFO::Creating boxplot for categorical data, diagnosis vs F113
## 2024-06-26 19:48:46.845191 INFO::Creating boxplot for categorical data, diagnosis vs F336
## 2024-06-26 19:48:47.140909 INFO::Creating boxplot for categorical data, diagnosis vs F399
## 2024-06-26 19:48:47.332871 INFO::Creating boxplot for categorical data, diagnosis vs F416
## 2024-06-26 19:48:47.511301 INFO::Creating boxplot for categorical data, diagnosis vs F657
## 2024-06-26 19:48:47.678645 INFO::Creating boxplot for categorical data, diagnosis vs F241
## 2024-06-26 19:48:47.845226 INFO::Creating boxplot for categorical data, diagnosis vs F95
## 2024-06-26 19:48:48.040855 INFO::Creating boxplot for categorical data, diagnosis vs F128
## 2024-06-26 19:48:48.215964 INFO::Creating boxplot for categorical data, diagnosis vs F595
## 2024-06-26 19:48:48.389527 INFO::Creating boxplot for categorical data, diagnosis vs F428
## 2024-06-26 19:48:48.559554 INFO::Creating boxplot for categorical data, diagnosis vs F796
## 2024-06-26 19:48:48.73214 INFO::Creating boxplot for categorical data, diagnosis vs F709
## 2024-06-26 19:48:48.909488 INFO::Creating boxplot for categorical data, diagnosis vs F602
## 2024-06-26 19:48:49.190989 INFO::Creating boxplot for categorical data, diagnosis vs F293
## 2024-06-26 19:48:49.429827 INFO::Creating boxplot for categorical data, diagnosis vs F867
## 2024-06-26 19:48:49.663281 INFO::Creating boxplot for categorical data, diagnosis vs F108
## 2024-06-26 19:48:49.905662 INFO::Creating boxplot for categorical data, diagnosis vs F846
## 2024-06-26 19:48:50.141251 INFO::Creating boxplot for categorical data, diagnosis vs F633
## 2024-06-26 19:48:50.414131 INFO::Creating boxplot for categorical data, diagnosis vs F564
## 2024-06-26 19:48:50.653913 INFO::Creating boxplot for categorical data, diagnosis vs F183
## 2024-06-26 19:48:50.919919 INFO::Creating boxplot for categorical data, diagnosis vs F647
## 2024-06-26 19:48:51.237206 INFO::Creating boxplot for categorical data, diagnosis vs F288
## 2024-06-26 19:48:51.421144 INFO::Creating boxplot for categorical data, diagnosis vs F159
## 2024-06-26 19:48:51.687298 INFO::Creating boxplot for categorical data, diagnosis vs F638
## 2024-06-26 19:48:51.985854 INFO::Creating boxplot for categorical data, diagnosis vs F484
## 2024-06-26 19:48:52.212812 INFO::Creating boxplot for categorical data, diagnosis vs F20
## 2024-06-26 19:48:52.414802 INFO::Creating boxplot for categorical data, diagnosis vs F19
## 2024-06-26 19:48:52.599515 INFO::Creating boxplot for categorical data, diagnosis vs F897
## 2024-06-26 19:48:52.780215 INFO::Creating boxplot for categorical data, diagnosis vs F442
## 2024-06-26 19:48:53.005513 INFO::Creating boxplot for categorical data, diagnosis vs F372
## 2024-06-26 19:48:53.291603 INFO::Creating boxplot for categorical data, diagnosis vs F771
## 2024-06-26 19:48:53.526921 INFO::Creating boxplot for categorical data, diagnosis vs F370
## 2024-06-26 19:48:53.774341 INFO::Creating boxplot for categorical data, diagnosis vs F620
## 2024-06-26 19:48:54.014217 INFO::Creating boxplot for categorical data, diagnosis vs F753
## 2024-06-26 19:48:54.229563 INFO::Creating boxplot for categorical data, diagnosis vs F568
## 2024-06-26 19:48:54.454534 INFO::Creating boxplot for categorical data, diagnosis vs F312
## 2024-06-26 19:48:54.654567 INFO::Creating boxplot for categorical data, diagnosis vs F485
## 2024-06-26 19:48:54.843055 INFO::Creating boxplot for categorical data, diagnosis vs F627
## 2024-06-26 19:48:55.027629 INFO::Creating boxplot for categorical data, diagnosis vs F72
## 2024-06-26 19:48:55.216052 INFO::Creating boxplot for categorical data, diagnosis vs F575
## 2024-06-26 19:48:55.42435 INFO::Creating boxplot for categorical data, diagnosis vs F332
## 2024-06-26 19:48:55.65123 INFO::Creating boxplot for categorical data, diagnosis vs F674
## 2024-06-26 19:48:55.937983 INFO::Creating boxplot for categorical data, diagnosis vs F537
## 2024-06-26 19:48:56.188092 INFO::Creating boxplot for categorical data, diagnosis vs F839
## 2024-06-26 19:48:56.377544 INFO::Creating boxplot for categorical data, diagnosis vs F715
## 2024-06-26 19:48:56.571685 INFO::Creating boxplot for categorical data, diagnosis vs F768
## 2024-06-26 19:48:56.809851 INFO::Creating boxplot for categorical data, diagnosis vs F202
## 2024-06-26 19:48:57.053108 INFO::Creating boxplot for categorical data, diagnosis vs F756
## 2024-06-26 19:48:57.271697 INFO::Creating boxplot for categorical data, diagnosis vs F536
## 2024-06-26 19:48:57.466851 INFO::Creating boxplot for categorical data, diagnosis vs F677
## 2024-06-26 19:48:57.653367 INFO::Creating boxplot for categorical data, diagnosis vs F435
## 2024-06-26 19:48:57.944249 INFO::Creating boxplot for categorical data, diagnosis vs F574
## 2024-06-26 19:48:58.159084 INFO::Creating boxplot for categorical data, diagnosis vs F70
## 2024-06-26 19:48:58.343286 INFO::Creating boxplot for categorical data, diagnosis vs F146
## 2024-06-26 19:48:58.572701 INFO::Creating boxplot for categorical data, diagnosis vs F236
## 2024-06-26 19:48:58.750548 INFO::Creating boxplot for categorical data, diagnosis vs F527
## 2024-06-26 19:48:58.980584 INFO::Creating boxplot for categorical data, diagnosis vs F624
## 2024-06-26 19:48:59.200174 INFO::Creating boxplot for categorical data, diagnosis vs F426
## 2024-06-26 19:48:59.378351 INFO::Creating boxplot for categorical data, diagnosis vs F880
## 2024-06-26 19:48:59.549211 INFO::Creating boxplot for categorical data, diagnosis vs F549
## 2024-06-26 19:48:59.823826 INFO::Creating boxplot for categorical data, diagnosis vs F49
## 2024-06-26 19:49:00.101 INFO::Creating boxplot for categorical data, diagnosis vs F67
## 2024-06-26 19:49:00.349961 INFO::Creating boxplot for categorical data, diagnosis vs F491
## 2024-06-26 19:49:00.53429 INFO::Creating boxplot for categorical data, diagnosis vs F174
## 2024-06-26 19:49:00.712736 INFO::Creating boxplot for categorical data, diagnosis vs F254
## 2024-06-26 19:49:00.88862 INFO::Creating boxplot for categorical data, diagnosis vs F112
## 2024-06-26 19:49:01.065618 INFO::Creating boxplot for categorical data, diagnosis vs F235
## 2024-06-26 19:49:01.331634 INFO::Creating boxplot for categorical data, diagnosis vs F833
## 2024-06-26 19:49:01.629273 INFO::Creating boxplot for categorical data, diagnosis vs F752
## 2024-06-26 19:49:01.829192 INFO::Creating boxplot for categorical data, diagnosis vs F792
## 2024-06-26 19:49:02.003077 INFO::Creating boxplot for categorical data, diagnosis vs F422
## 2024-06-26 19:49:02.24649 INFO::Creating boxplot for categorical data, diagnosis vs F6
## 2024-06-26 19:49:02.48242 INFO::Creating boxplot for categorical data, diagnosis vs F463
## 2024-06-26 19:49:02.657431 INFO::Creating boxplot for categorical data, diagnosis vs F706
## 2024-06-26 19:49:02.860522 INFO::Creating boxplot for categorical data, diagnosis vs F642
## 2024-06-26 19:49:03.044826 INFO::Creating boxplot for categorical data, diagnosis vs F65
## 2024-06-26 19:49:03.222332 INFO::Creating boxplot for categorical data, diagnosis vs F102
## 2024-06-26 19:49:03.389162 INFO::Creating boxplot for categorical data, diagnosis vs F783
## 2024-06-26 19:49:03.558002 INFO::Creating boxplot for categorical data, diagnosis vs F478
## 2024-06-26 19:49:03.762236 INFO::Creating boxplot for categorical data, diagnosis vs F889
## 2024-06-26 19:49:03.974855 INFO::Creating boxplot for categorical data, diagnosis vs F350
## 2024-06-26 19:49:04.186738 INFO::Creating boxplot for categorical data, diagnosis vs F681
## 2024-06-26 19:49:04.35395 INFO::Creating boxplot for categorical data, diagnosis vs F748
## 2024-06-26 19:49:04.908456 INFO::Creating boxplot for categorical data, diagnosis vs F762
## 2024-06-26 19:49:05.095713 INFO::Creating boxplot for categorical data, diagnosis vs F852
## 2024-06-26 19:49:05.318344 INFO::Creating boxplot for categorical data, diagnosis vs F180
## 2024-06-26 19:49:05.524244 INFO::Creating boxplot for categorical data, diagnosis vs F248
## 2024-06-26 19:49:05.764705 INFO::Creating boxplot for categorical data, diagnosis vs F759
## 2024-06-26 19:49:05.934566 INFO::Creating boxplot for categorical data, diagnosis vs F824
## 2024-06-26 19:49:06.176014 INFO::Creating boxplot for categorical data, diagnosis vs F145
## 2024-06-26 19:49:06.415888 INFO::Creating boxplot for categorical data, diagnosis vs F16
## 2024-06-26 19:49:06.669748 INFO::Creating boxplot for categorical data, diagnosis vs F169
## 2024-06-26 19:49:06.879423 INFO::Creating boxplot for categorical data, diagnosis vs F392
## 2024-06-26 19:49:07.058057 INFO::Creating boxplot for categorical data, diagnosis vs F468
## 2024-06-26 19:49:07.281643 INFO::Creating boxplot for categorical data, diagnosis vs F476
## 2024-06-26 19:49:07.476997 INFO::Creating boxplot for categorical data, diagnosis vs F699
## 2024-06-26 19:49:07.695033 INFO::Creating boxplot for categorical data, diagnosis vs F735
## 2024-06-26 19:49:07.93607 INFO::Creating boxplot for categorical data, diagnosis vs F182
## 2024-06-26 19:49:08.127687 INFO::Creating boxplot for categorical data, diagnosis vs F64
## 2024-06-26 19:49:08.314888 INFO::Creating boxplot for categorical data, diagnosis vs F203
## 2024-06-26 19:49:08.488788 INFO::Creating boxplot for categorical data, diagnosis vs F877
## 2024-06-26 19:49:08.696205 INFO::Creating boxplot for categorical data, diagnosis vs F433
## 2024-06-26 19:49:08.898079 INFO::Creating boxplot for categorical data, diagnosis vs F739
## 2024-06-26 19:49:09.173931 INFO::Creating boxplot for categorical data, diagnosis vs F749
## 2024-06-26 19:49:09.410447 INFO::Creating boxplot for categorical data, diagnosis vs F382
## 2024-06-26 19:49:09.650503 INFO::Creating boxplot for categorical data, diagnosis vs F162
## 2024-06-26 19:49:09.847349 INFO::Creating boxplot for categorical data, diagnosis vs F438
## 2024-06-26 19:49:10.045262 INFO::Creating boxplot for categorical data, diagnosis vs F360
## 2024-06-26 19:49:10.227875 INFO::Creating boxplot for categorical data, diagnosis vs F56
## 2024-06-26 19:49:10.403908 INFO::Creating boxplot for categorical data, diagnosis vs F529
## 2024-06-26 19:49:10.581471 INFO::Creating boxplot for categorical data, diagnosis vs F48
## 2024-06-26 19:49:10.873774 INFO::Creating boxplot for categorical data, diagnosis vs F826
## 2024-06-26 19:49:11.112475 INFO::Creating boxplot for categorical data, diagnosis vs F488
## 2024-06-26 19:49:11.384596 INFO::Creating boxplot for categorical data, diagnosis vs F309
## 2024-06-26 19:49:11.629173 INFO::Creating boxplot for categorical data, diagnosis vs F834
## 2024-06-26 19:49:11.874738 INFO::Creating boxplot for categorical data, diagnosis vs F449
## 2024-06-26 19:49:12.093265 INFO::Creating boxplot for categorical data, diagnosis vs F77
## 2024-06-26 19:49:12.293499 INFO::Creating boxplot for categorical data, diagnosis vs F365
## 2024-06-26 19:49:12.497142 INFO::Creating boxplot for categorical data, diagnosis vs F346
## 2024-06-26 19:49:12.67707 INFO::Creating boxplot for categorical data, diagnosis vs F654
## 2024-06-26 19:49:12.856395 INFO::Creating boxplot for categorical data, diagnosis vs F79
## 2024-06-26 19:49:13.031937 INFO::Creating boxplot for categorical data, diagnosis vs F785
## 2024-06-26 19:49:13.232232 INFO::Creating boxplot for categorical data, diagnosis vs F415
## 2024-06-26 19:49:13.444676 INFO::Creating boxplot for categorical data, diagnosis vs F466
## 2024-06-26 19:49:13.649566 INFO::Creating boxplot for categorical data, diagnosis vs F643
## 2024-06-26 19:49:13.835322 INFO::Creating boxplot for categorical data, diagnosis vs F160
## 2024-06-26 19:49:14.010274 INFO::Creating boxplot for categorical data, diagnosis vs F69
## 2024-06-26 19:49:14.200554 INFO::Creating boxplot for categorical data, diagnosis vs F498
## 2024-06-26 19:49:14.413723 INFO::Creating boxplot for categorical data, diagnosis vs F207
## 2024-06-26 19:49:14.61375 INFO::Creating boxplot for categorical data, diagnosis vs F679
## 2024-06-26 19:49:14.839677 INFO::Creating boxplot for categorical data, diagnosis vs F618
## 2024-06-26 19:49:15.060799 INFO::Creating boxplot for categorical data, diagnosis vs F255
## 2024-06-26 19:49:15.262151 INFO::Creating boxplot for categorical data, diagnosis vs F267
## 2024-06-26 19:49:15.445017 INFO::Creating boxplot for categorical data, diagnosis vs F143
## 2024-06-26 19:49:15.625607 INFO::Creating boxplot for categorical data, diagnosis vs F286
## 2024-06-26 19:49:15.825234 INFO::Creating boxplot for categorical data, diagnosis vs F562
## 2024-06-26 19:49:16.00791 INFO::Creating boxplot for categorical data, diagnosis vs F100
## 2024-06-26 19:49:16.206906 INFO::Creating boxplot for categorical data, diagnosis vs F374
## 2024-06-26 19:49:16.397924 INFO::Creating boxplot for categorical data, diagnosis vs F535
## 2024-06-26 19:49:16.57361 INFO::Creating boxplot for categorical data, diagnosis vs F658
## 2024-06-26 19:49:16.782223 INFO::Creating boxplot for categorical data, diagnosis vs F707
## 2024-06-26 19:49:16.967415 INFO::Creating boxplot for categorical data, diagnosis vs F325
## 2024-06-26 19:49:17.151524 INFO::Creating boxplot for categorical data, diagnosis vs F89
## 2024-06-26 19:49:17.35945 INFO::Creating boxplot for categorical data, diagnosis vs F214
## 2024-06-26 19:49:17.553936 INFO::Creating boxplot for categorical data, diagnosis vs F578
## 2024-06-26 19:49:17.747442 INFO::Creating boxplot for categorical data, diagnosis vs F790
## 2024-06-26 19:49:18.042584 INFO::Creating boxplot for categorical data, diagnosis vs F265
## 2024-06-26 19:49:18.316821 INFO::Creating boxplot for categorical data, diagnosis vs F253
## 2024-06-26 19:49:18.583762 INFO::Creating boxplot for categorical data, diagnosis vs F294
## 2024-06-26 19:49:18.831794 INFO::Creating boxplot for categorical data, diagnosis vs F410
## 2024-06-26 19:49:19.025582 INFO::Creating boxplot for categorical data, diagnosis vs F614
## 2024-06-26 19:49:19.340467 INFO::Creating boxplot for categorical data, diagnosis vs F764
## 2024-06-26 19:49:19.542307 INFO::Creating boxplot for categorical data, diagnosis vs F59
## 2024-06-26 19:49:19.77646 INFO::Creating boxplot for categorical data, diagnosis vs F675
## 2024-06-26 19:49:19.955115 INFO::Creating boxplot for categorical data, diagnosis vs F441
## 2024-06-26 19:49:20.199598 INFO::Creating boxplot for categorical data, diagnosis vs F193
## 2024-06-26 19:49:20.445849 INFO::Creating boxplot for categorical data, diagnosis vs F689
## 2024-06-26 19:49:20.7346 INFO::Creating boxplot for categorical data, diagnosis vs F249
## 2024-06-26 19:49:21.020033 INFO::Creating boxplot for categorical data, diagnosis vs F821
## 2024-06-26 19:49:21.267793 INFO::Creating boxplot for categorical data, diagnosis vs F351
## 2024-06-26 19:49:21.466803 INFO::Creating boxplot for categorical data, diagnosis vs F66
## 2024-06-26 19:49:21.684729 INFO::Creating boxplot for categorical data, diagnosis vs F413
## 2024-06-26 19:49:21.917031 INFO::Creating boxplot for categorical data, diagnosis vs F172
## 2024-06-26 19:49:22.10556 INFO::Creating boxplot for categorical data, diagnosis vs F317
## 2024-06-26 19:49:22.326326 INFO::Creating boxplot for categorical data, diagnosis vs F167
## 2024-06-26 19:49:22.531533 INFO::Creating boxplot for categorical data, diagnosis vs F229
## 2024-06-26 19:49:22.797546 INFO::Creating boxplot for categorical data, diagnosis vs F243
## 2024-06-26 19:49:23.865827 INFO::Creating boxplot for categorical data, diagnosis vs F732
## 2024-06-26 19:49:24.06684 INFO::Creating boxplot for categorical data, diagnosis vs F467
## 2024-06-26 19:49:24.260875 INFO::Creating boxplot for categorical data, diagnosis vs F474
## 2024-06-26 19:49:24.503243 INFO::Creating boxplot for categorical data, diagnosis vs F156
## 2024-06-26 19:49:24.720176 INFO::Creating boxplot for categorical data, diagnosis vs F786
## 2024-06-26 19:49:24.913324 INFO::Creating boxplot for categorical data, diagnosis vs F216
## 2024-06-26 19:49:25.133928 INFO::Creating boxplot for categorical data, diagnosis vs F85
## 2024-06-26 19:49:25.380245 INFO::Creating boxplot for categorical data, diagnosis vs F621
## 2024-06-26 19:49:25.589594 INFO::Creating boxplot for categorical data, diagnosis vs F558
## 2024-06-26 19:49:25.765483 INFO::Creating boxplot for categorical data, diagnosis vs F582
## 2024-06-26 19:49:25.950605 INFO::Creating boxplot for categorical data, diagnosis vs F898
## 2024-06-26 19:49:26.13952 INFO::Creating boxplot for categorical data, diagnosis vs F402
## 2024-06-26 19:49:26.379983 INFO::Creating boxplot for categorical data, diagnosis vs F71
## 2024-06-26 19:49:26.634799 INFO::Creating boxplot for categorical data, diagnosis vs F99
## 2024-06-26 19:49:26.823686 INFO::Creating boxplot for categorical data, diagnosis vs F366
## 2024-06-26 19:49:27.06884 INFO::Creating boxplot for categorical data, diagnosis vs F778
## 2024-06-26 19:49:27.33942 INFO::Creating boxplot for categorical data, diagnosis vs F188
## 2024-06-26 19:49:27.862903 INFO::Creating boxplot for categorical data, diagnosis vs F857
## 2024-06-26 19:49:28.110672 INFO::Creating boxplot for categorical data, diagnosis vs F440
## 2024-06-26 19:49:28.307233 INFO::Creating boxplot for categorical data, diagnosis vs F799
## 2024-06-26 19:49:28.532845 INFO::Creating boxplot for categorical data, diagnosis vs F482
## 2024-06-26 19:49:28.716959 INFO::Creating boxplot for categorical data, diagnosis vs F212
## 2024-06-26 19:49:28.884661 INFO::Creating boxplot for categorical data, diagnosis vs F882
## 2024-06-26 19:49:29.079291 INFO::Creating boxplot for categorical data, diagnosis vs F599
## 2024-06-26 19:49:29.267054 INFO::Creating boxplot for categorical data, diagnosis vs F302
## 2024-06-26 19:49:29.44514 INFO::Creating boxplot for categorical data, diagnosis vs F543
## 2024-06-26 19:49:29.640949 INFO::Creating boxplot for categorical data, diagnosis vs F269
## 2024-06-26 19:49:29.849568 INFO::Creating boxplot for categorical data, diagnosis vs F650
## 2024-06-26 19:49:30.108868 INFO::Creating boxplot for categorical data, diagnosis vs F456
## 2024-06-26 19:49:30.378125 INFO::Creating boxplot for categorical data, diagnosis vs F573
## 2024-06-26 19:49:30.638056 INFO::Creating boxplot for categorical data, diagnosis vs F8
## 2024-06-26 19:49:30.883929 INFO::Creating boxplot for categorical data, diagnosis vs F810
## 2024-06-26 19:49:31.172179 INFO::Creating boxplot for categorical data, diagnosis vs F401
## 2024-06-26 19:49:31.392424 INFO::Creating boxplot for categorical data, diagnosis vs F606
## 2024-06-26 19:49:31.695391 INFO::Creating boxplot for categorical data, diagnosis vs F662
## 2024-06-26 19:49:31.952328 INFO::Creating boxplot for categorical data, diagnosis vs F765
## 2024-06-26 19:49:32.143904 INFO::Creating boxplot for categorical data, diagnosis vs F887
## 2024-06-26 19:49:32.327216 INFO::Creating boxplot for categorical data, diagnosis vs F770
## 2024-06-26 19:49:32.531062 INFO::Creating boxplot for categorical data, diagnosis vs F469
## 2024-06-26 19:49:32.726282 INFO::Creating boxplot for categorical data, diagnosis vs F86
## 2024-06-26 19:49:32.930532 INFO::Creating boxplot for categorical data, diagnosis vs F400
## 2024-06-26 19:49:33.157607 INFO::Creating boxplot for categorical data, diagnosis vs F579
## 2024-06-26 19:49:33.347733 INFO::Creating boxplot for categorical data, diagnosis vs F871
## 2024-06-26 19:49:33.588892 INFO::Creating boxplot for categorical data, diagnosis vs F37
## 2024-06-26 19:49:33.783553 INFO::Creating boxplot for categorical data, diagnosis vs F446
## 2024-06-26 19:49:34.0199 INFO::Creating boxplot for categorical data, diagnosis vs F218
## 2024-06-26 19:49:34.263026 INFO::Creating boxplot for categorical data, diagnosis vs F321
## 2024-06-26 19:49:34.546765 INFO::Creating boxplot for categorical data, diagnosis vs F487
## 2024-06-26 19:49:34.773248 INFO::Creating boxplot for categorical data, diagnosis vs F740
## 2024-06-26 19:49:35.003388 INFO::Creating boxplot for categorical data, diagnosis vs F141
## 2024-06-26 19:49:35.230022 INFO::Creating boxplot for categorical data, diagnosis vs F327
## 2024-06-26 19:49:35.474317 INFO::Creating boxplot for categorical data, diagnosis vs F196
## 2024-06-26 19:49:35.657413 INFO::Creating boxplot for categorical data, diagnosis vs F883
## 2024-06-26 19:49:35.878916 INFO::Creating boxplot for categorical data, diagnosis vs F279
## 2024-06-26 19:49:36.07076 INFO::Creating boxplot for categorical data, diagnosis vs F838
## 2024-06-26 19:49:36.273825 INFO::Creating boxplot for categorical data, diagnosis vs F451
## 2024-06-26 19:49:36.478544 INFO::Creating boxplot for categorical data, diagnosis vs F854
## 2024-06-26 19:49:36.661953 INFO::Creating boxplot for categorical data, diagnosis vs F434
## 2024-06-26 19:49:36.843114 INFO::Creating boxplot for categorical data, diagnosis vs F519
## 2024-06-26 19:49:37.014126 INFO::Creating boxplot for categorical data, diagnosis vs F694
## 2024-06-26 19:49:37.196458 INFO::Creating boxplot for categorical data, diagnosis vs F561
## 2024-06-26 19:49:37.373751 INFO::Creating boxplot for categorical data, diagnosis vs F10
## 2024-06-26 19:49:37.558774 INFO::Creating boxplot for categorical data, diagnosis vs F303
## 2024-06-26 19:49:37.803571 INFO::Creating boxplot for categorical data, diagnosis vs F512
## 2024-06-26 19:49:38.022931 INFO::Creating boxplot for categorical data, diagnosis vs F645
## 2024-06-26 19:49:38.208731 INFO::Creating boxplot for categorical data, diagnosis vs F793
## 2024-06-26 19:49:38.515253 INFO::Creating boxplot for categorical data, diagnosis vs F404
## 2024-06-26 19:49:38.795153 INFO::Creating boxplot for categorical data, diagnosis vs F362
## 2024-06-26 19:49:39.097488 INFO::Creating boxplot for categorical data, diagnosis vs F525
## 2024-06-26 19:49:39.292636 INFO::Creating boxplot for categorical data, diagnosis vs F742
## 2024-06-26 19:49:39.485633 INFO::Creating boxplot for categorical data, diagnosis vs F276
## 2024-06-26 19:49:39.661996 INFO::Creating boxplot for categorical data, diagnosis vs F499
## 2024-06-26 19:49:39.849209 INFO::Creating boxplot for categorical data, diagnosis vs F328
## 2024-06-26 19:49:40.049974 INFO::Creating boxplot for categorical data, diagnosis vs F787
## 2024-06-26 19:49:40.259515 INFO::Creating boxplot for categorical data, diagnosis vs F30
## 2024-06-26 19:49:40.446605 INFO::Creating boxplot for categorical data, diagnosis vs F122
## 2024-06-26 19:49:40.664067 INFO::Creating boxplot for categorical data, diagnosis vs F619
## 2024-06-26 19:49:40.892773 INFO::Creating boxplot for categorical data, diagnosis vs F572
## 2024-06-26 19:49:41.094731 INFO::Creating boxplot for categorical data, diagnosis vs F47
## 2024-06-26 19:49:41.296621 INFO::Creating boxplot for categorical data, diagnosis vs F570
## 2024-06-26 19:49:41.458808 INFO::Creating boxplot for categorical data, diagnosis vs F26
## 2024-06-26 19:49:41.626169 INFO::Creating boxplot for categorical data, diagnosis vs F252
## 2024-06-26 19:49:41.791361 INFO::Creating boxplot for categorical data, diagnosis vs F117
## 2024-06-26 19:49:41.96139 INFO::Creating boxplot for categorical data, diagnosis vs F683
## 2024-06-26 19:49:42.160456 INFO::Creating boxplot for categorical data, diagnosis vs F395
## 2024-06-26 19:49:42.363297 INFO::Creating boxplot for categorical data, diagnosis vs F822
## 2024-06-26 19:49:42.530545 INFO::Creating boxplot for categorical data, diagnosis vs F46
## 2024-06-26 19:49:42.707605 INFO::Creating boxplot for categorical data, diagnosis vs F154
## 2024-06-26 19:49:42.908046 INFO::Creating boxplot for categorical data, diagnosis vs F540
## 2024-06-26 19:49:43.079747 INFO::Creating boxplot for categorical data, diagnosis vs F884
## 2024-06-26 19:49:43.302538 INFO::Creating boxplot for categorical data, diagnosis vs F368
## 2024-06-26 19:49:43.495516 INFO::Creating boxplot for categorical data, diagnosis vs F607
## 2024-06-26 19:49:43.69865 INFO::Creating boxplot for categorical data, diagnosis vs F111
## 2024-06-26 19:49:43.917867 INFO::Creating boxplot for categorical data, diagnosis vs F745
## 2024-06-26 19:49:44.18526 INFO::Creating boxplot for categorical data, diagnosis vs F673
## 2024-06-26 19:49:44.386277 INFO::Creating boxplot for categorical data, diagnosis vs F92
## 2024-06-26 19:49:44.664798 INFO::Creating boxplot for categorical data, diagnosis vs F493
## 2024-06-26 19:49:44.962005 INFO::Creating boxplot for categorical data, diagnosis vs F835
## 2024-06-26 19:49:45.239626 INFO::Creating boxplot for categorical data, diagnosis vs F872
## 2024-06-26 19:49:45.45901 INFO::Creating boxplot for categorical data, diagnosis vs F879
## 2024-06-26 19:49:45.75705 INFO::Creating boxplot for categorical data, diagnosis vs F432
## 2024-06-26 19:49:46.080483 INFO::Creating boxplot for categorical data, diagnosis vs F518
## 2024-06-26 19:49:46.373947 INFO::Creating boxplot for categorical data, diagnosis vs F44
## 2024-06-26 19:49:46.647996 INFO::Creating boxplot for categorical data, diagnosis vs F240
## 2024-06-26 19:49:46.867571 INFO::Creating boxplot for categorical data, diagnosis vs F819
## 2024-06-26 19:49:47.063604 INFO::Creating boxplot for categorical data, diagnosis vs F411
## 2024-06-26 19:49:47.265912 INFO::Creating boxplot for categorical data, diagnosis vs F353
## 2024-06-26 19:49:47.485793 INFO::Creating boxplot for categorical data, diagnosis vs F763
## 2024-06-26 19:49:47.761039 INFO::Creating boxplot for categorical data, diagnosis vs F97
## 2024-06-26 19:49:47.988798 INFO::Creating boxplot for categorical data, diagnosis vs F40
## 2024-06-26 19:49:48.246534 INFO::Creating boxplot for categorical data, diagnosis vs F652
## 2024-06-26 19:49:48.474348 INFO::Creating boxplot for categorical data, diagnosis vs F789
## 2024-06-26 19:49:48.777034 INFO::Creating boxplot for categorical data, diagnosis vs F25
## 2024-06-26 19:49:49.043928 INFO::Creating boxplot for categorical data, diagnosis vs F256
## 2024-06-26 19:49:49.297212 INFO::Creating boxplot for categorical data, diagnosis vs F423
## 2024-06-26 19:49:49.496702 INFO::Creating boxplot for categorical data, diagnosis vs F594
## 2024-06-26 19:49:49.683856 INFO::Creating boxplot for categorical data, diagnosis vs F201
## 2024-06-26 19:49:50.051793 INFO::Creating boxplot for categorical data, diagnosis vs F813
## 2024-06-26 19:49:50.24308 INFO::Creating boxplot for categorical data, diagnosis vs F653
## 2024-06-26 19:49:50.420613 INFO::Creating boxplot for categorical data, diagnosis vs F524
## 2024-06-26 19:49:50.636003 INFO::Creating boxplot for categorical data, diagnosis vs F777
## 2024-06-26 19:49:50.868135 INFO::Creating boxplot for categorical data, diagnosis vs F226
## 2024-06-26 19:49:51.049841 INFO::Creating boxplot for categorical data, diagnosis vs F227
## 2024-06-26 19:49:51.301797 INFO::Creating boxplot for categorical data, diagnosis vs F521
## 2024-06-26 19:49:51.483778 INFO::Creating boxplot for categorical data, diagnosis vs F14
## 2024-06-26 19:49:51.658657 INFO::Creating boxplot for categorical data, diagnosis vs F310
## 2024-06-26 19:49:51.866514 INFO::Creating boxplot for categorical data, diagnosis vs F452
## 2024-06-26 19:49:52.142248 INFO::Creating boxplot for categorical data, diagnosis vs F52
## 2024-06-26 19:49:52.433644 INFO::Creating boxplot for categorical data, diagnosis vs F53
## 2024-06-26 19:49:53.039408 INFO::Creating boxplot for categorical data, diagnosis vs F844
## 2024-06-26 19:49:53.336082 INFO::Creating boxplot for categorical data, diagnosis vs F31
## 2024-06-26 19:49:53.59536 INFO::Creating boxplot for categorical data, diagnosis vs F795
## 2024-06-26 19:49:53.782435 INFO::Creating boxplot for categorical data, diagnosis vs F766
## 2024-06-26 19:49:54.00619 INFO::Creating boxplot for categorical data, diagnosis vs F342
## 2024-06-26 19:49:54.212656 INFO::Creating boxplot for categorical data, diagnosis vs F408
## 2024-06-26 19:49:54.526579 INFO::Creating boxplot for categorical data, diagnosis vs F282
## 2024-06-26 19:49:54.799822 INFO::Creating boxplot for categorical data, diagnosis vs F508
## 2024-06-26 19:49:55.080872 INFO::Creating boxplot for categorical data, diagnosis vs F805
## 2024-06-26 19:49:55.349211 INFO::Creating boxplot for categorical data, diagnosis vs F337
## 2024-06-26 19:49:55.648958 INFO::Creating boxplot for categorical data, diagnosis vs F820
## 2024-06-26 19:49:55.982182 INFO::Creating boxplot for categorical data, diagnosis vs F593
## 2024-06-26 19:49:56.256331 INFO::Creating boxplot for categorical data, diagnosis vs F701
## 2024-06-26 19:49:56.490377 INFO::Creating boxplot for categorical data, diagnosis vs F459
## 2024-06-26 19:49:56.789964 INFO::Creating boxplot for categorical data, diagnosis vs F305
## 2024-06-26 19:49:57.032821 INFO::Creating boxplot for categorical data, diagnosis vs F142
## 2024-06-26 19:49:57.274996 INFO::Creating boxplot for categorical data, diagnosis vs F534
## 2024-06-26 19:49:57.594836 INFO::Creating boxplot for categorical data, diagnosis vs F135
## 2024-06-26 19:49:57.809584 INFO::Creating boxplot for categorical data, diagnosis vs F702
## 2024-06-26 19:49:58.000997 INFO::Creating boxplot for categorical data, diagnosis vs F776
## 2024-06-26 19:49:58.197154 INFO::Creating boxplot for categorical data, diagnosis vs F295
## 2024-06-26 19:49:58.410802 INFO::Creating boxplot for categorical data, diagnosis vs F355
## 2024-06-26 19:49:58.666978 INFO::Creating boxplot for categorical data, diagnosis vs F797
## 2024-06-26 19:49:58.889344 INFO::Creating boxplot for categorical data, diagnosis vs F13
## 2024-06-26 19:49:59.089546 INFO::Creating boxplot for categorical data, diagnosis vs F356
## 2024-06-26 19:49:59.388908 INFO::Creating boxplot for categorical data, diagnosis vs F359
## 2024-06-26 19:49:59.679367 INFO::Creating boxplot for categorical data, diagnosis vs F121
## 2024-06-26 19:49:59.945475 INFO::Creating boxplot for categorical data, diagnosis vs F850
## 2024-06-26 19:50:00.25682 INFO::Creating boxplot for categorical data, diagnosis vs F899
## 2024-06-26 19:50:00.54297 INFO::Creating boxplot for categorical data, diagnosis vs F628
## 2024-06-26 19:50:00.821276 INFO::Creating boxplot for categorical data, diagnosis vs F843
## 2024-06-26 19:50:01.045379 INFO::Creating boxplot for categorical data, diagnosis vs F107
## 2024-06-26 19:50:01.253378 INFO::Creating boxplot for categorical data, diagnosis vs F287
## 2024-06-26 19:50:01.439725 INFO::Creating boxplot for categorical data, diagnosis vs F165
## 2024-06-26 19:50:01.649542 INFO::Creating boxplot for categorical data, diagnosis vs F557
## 2024-06-26 19:50:01.870557 INFO::Creating boxplot for categorical data, diagnosis vs F127
## 2024-06-26 19:50:02.138368 INFO::Creating boxplot for categorical data, diagnosis vs F299
## 2024-06-26 19:50:02.324806 INFO::Creating boxplot for categorical data, diagnosis vs F497
## 2024-06-26 19:50:02.499574 INFO::Creating boxplot for categorical data, diagnosis vs F711
## 2024-06-26 19:50:02.705168 INFO::Creating boxplot for categorical data, diagnosis vs F319
## 2024-06-26 19:50:03.000086 INFO::Creating boxplot for categorical data, diagnosis vs F271
## 2024-06-26 19:50:03.291995 INFO::Creating boxplot for categorical data, diagnosis vs F157
## 2024-06-26 19:50:03.497224 INFO::Creating boxplot for categorical data, diagnosis vs F560
## 2024-06-26 19:50:03.767003 INFO::Creating boxplot for categorical data, diagnosis vs F680
## 2024-06-26 19:50:04.025934 INFO::Creating boxplot for categorical data, diagnosis vs F580
## 2024-06-26 19:50:04.365906 INFO::Creating boxplot for categorical data, diagnosis vs F152
## 2024-06-26 19:50:04.627658 INFO::Creating boxplot for categorical data, diagnosis vs F12
## 2024-06-26 19:50:04.898099 INFO::Creating boxplot for categorical data, diagnosis vs F324
## 2024-06-26 19:50:05.191681 INFO::Creating boxplot for categorical data, diagnosis vs F893
## 2024-06-26 19:50:05.411807 INFO::Creating boxplot for categorical data, diagnosis vs F318
## 2024-06-26 19:50:05.619045 INFO::Creating boxplot for categorical data, diagnosis vs F784
## 2024-06-26 19:50:05.832142 INFO::Creating boxplot for categorical data, diagnosis vs F567
## 2024-06-26 19:50:06.109857 INFO::Creating boxplot for categorical data, diagnosis vs F457
## 2024-06-26 19:50:06.346572 INFO::Creating boxplot for categorical data, diagnosis vs F708
## 2024-06-26 19:50:06.643784 INFO::Creating boxplot for categorical data, diagnosis vs F669
## 2024-06-26 19:50:06.918614 INFO::Creating boxplot for categorical data, diagnosis vs F87
## 2024-06-26 19:50:09.755464 INFO::Plotting data for metadata number 2, antibiotics
## 2024-06-26 19:50:09.759825 INFO::Creating boxplot for categorical data, antibiotics vs F663
## 2024-06-26 19:50:10.052337 INFO::Creating boxplot for categorical data, antibiotics vs F838
## 2024-06-26 19:50:10.407589 INFO::Creating boxplot for categorical data, antibiotics vs F764
## 2024-06-26 19:50:10.659121 INFO::Creating boxplot for categorical data, antibiotics vs F880
## 2024-06-26 19:50:10.905853 INFO::Creating boxplot for categorical data, antibiotics vs F751
## 2024-06-26 19:50:11.149675 INFO::Creating boxplot for categorical data, antibiotics vs F288
## 2024-06-26 19:50:11.484858 INFO::Creating boxplot for categorical data, antibiotics vs F65
## 2024-06-26 19:50:11.823681 INFO::Creating boxplot for categorical data, antibiotics vs F742
## 2024-06-26 19:50:12.116255 INFO::Creating boxplot for categorical data, antibiotics vs F528
## 2024-06-26 19:50:12.420566 INFO::Creating boxplot for categorical data, antibiotics vs F790
## 2024-06-26 19:50:12.716092 INFO::Creating boxplot for categorical data, antibiotics vs F777
## 2024-06-26 19:50:12.967345 INFO::Creating boxplot for categorical data, antibiotics vs F178
## 2024-06-26 19:50:13.284277 INFO::Creating boxplot for categorical data, antibiotics vs F139
## 2024-06-26 19:50:13.601433 INFO::Creating boxplot for categorical data, antibiotics vs F202
## 2024-06-26 19:50:13.869504 INFO::Creating boxplot for categorical data, antibiotics vs F220
## 2024-06-26 19:50:14.057607 INFO::Creating boxplot for categorical data, antibiotics vs F397
## 2024-06-26 19:50:14.279295 INFO::Creating boxplot for categorical data, antibiotics vs F882
## 2024-06-26 19:50:14.530097 INFO::Creating boxplot for categorical data, antibiotics vs F446
## 2024-06-26 19:50:14.822775 INFO::Creating boxplot for categorical data, antibiotics vs F418
## 2024-06-26 19:50:15.037944 INFO::Creating boxplot for categorical data, antibiotics vs F133
## 2024-06-26 19:50:15.23823 INFO::Creating boxplot for categorical data, antibiotics vs F696
## 2024-06-26 19:50:15.422094 INFO::Creating boxplot for categorical data, antibiotics vs F548
## 2024-06-26 19:50:15.706531 INFO::Creating boxplot for categorical data, antibiotics vs F536
## 2024-06-26 19:50:16.025645 INFO::Creating boxplot for categorical data, antibiotics vs F194
## 2024-06-26 19:50:16.338329 INFO::Creating boxplot for categorical data, antibiotics vs F34
## 2024-06-26 19:50:16.607946 INFO::Creating boxplot for categorical data, antibiotics vs F153
## 2024-06-26 19:50:16.791314 INFO::Creating boxplot for categorical data, antibiotics vs F400
## 2024-06-26 19:50:17.037618 INFO::Creating boxplot for categorical data, antibiotics vs F794
## 2024-06-26 19:50:17.339677 INFO::Creating boxplot for categorical data, antibiotics vs F396
## 2024-06-26 19:50:17.564551 INFO::Creating boxplot for categorical data, antibiotics vs F182
## 2024-06-26 19:50:17.871611 INFO::Creating boxplot for categorical data, antibiotics vs F719
## 2024-06-26 19:50:18.178889 INFO::Creating boxplot for categorical data, antibiotics vs F109
## 2024-06-26 19:50:18.499116 INFO::Creating boxplot for categorical data, antibiotics vs F180
## 2024-06-26 19:50:18.852495 INFO::Creating boxplot for categorical data, antibiotics vs F552
## 2024-06-26 19:50:19.106175 INFO::Creating boxplot for categorical data, antibiotics vs F789
## 2024-06-26 19:50:19.369368 INFO::Creating boxplot for categorical data, antibiotics vs F893
## 2024-06-26 19:50:19.63263 INFO::Creating boxplot for categorical data, antibiotics vs F834
## 2024-06-26 19:50:19.93102 INFO::Creating boxplot for categorical data, antibiotics vs F889
## 2024-06-26 19:50:20.240366 INFO::Creating boxplot for categorical data, antibiotics vs F143
## 2024-06-26 19:50:20.466279 INFO::Creating boxplot for categorical data, antibiotics vs F224
## 2024-06-26 19:50:20.768319 INFO::Creating boxplot for categorical data, antibiotics vs F5
## 2024-06-26 19:50:21.089316 INFO::Creating boxplot for categorical data, antibiotics vs F873
## 2024-06-26 19:50:21.417568 INFO::Creating boxplot for categorical data, antibiotics vs F452
## 2024-06-26 19:50:21.776095 INFO::Creating boxplot for categorical data, antibiotics vs F681
## 2024-06-26 19:50:22.097317 INFO::Creating boxplot for categorical data, antibiotics vs F468
## 2024-06-26 19:50:22.305019 INFO::Creating boxplot for categorical data, antibiotics vs F731
## 2024-06-26 19:50:22.536533 INFO::Creating boxplot for categorical data, antibiotics vs F479
## 2024-06-26 19:50:22.840512 INFO::Creating boxplot for categorical data, antibiotics vs F520
## 2024-06-26 19:50:23.135004 INFO::Creating boxplot for categorical data, antibiotics vs F649
## 2024-06-26 19:50:23.364183 INFO::Creating boxplot for categorical data, antibiotics vs F259
## 2024-06-26 19:50:23.611785 INFO::Creating boxplot for categorical data, antibiotics vs F186
## 2024-06-26 19:50:23.927479 INFO::Creating boxplot for categorical data, antibiotics vs F312
## 2024-06-26 19:50:24.226219 INFO::Creating boxplot for categorical data, antibiotics vs F477
## 2024-06-26 19:50:24.413837 INFO::Creating boxplot for categorical data, antibiotics vs F4
## 2024-06-26 19:50:24.6741 INFO::Creating boxplot for categorical data, antibiotics vs F632
## 2024-06-26 19:50:24.976469 INFO::Creating boxplot for categorical data, antibiotics vs F31
## 2024-06-26 19:50:25.247648 INFO::Creating boxplot for categorical data, antibiotics vs F184
## 2024-06-26 19:50:25.460629 INFO::Creating boxplot for categorical data, antibiotics vs F7
## 2024-06-26 19:50:25.663499 INFO::Creating boxplot for categorical data, antibiotics vs F213
## 2024-06-26 19:50:25.998449 INFO::Creating boxplot for categorical data, antibiotics vs F691
## 2024-06-26 19:50:26.205024 INFO::Creating boxplot for categorical data, antibiotics vs F828
## 2024-06-26 19:50:26.522674 INFO::Creating boxplot for categorical data, antibiotics vs F831
## 2024-06-26 19:50:26.796544 INFO::Creating boxplot for categorical data, antibiotics vs F315
## 2024-06-26 19:50:27.054823 INFO::Creating boxplot for categorical data, antibiotics vs F159
## 2024-06-26 19:50:27.357397 INFO::Creating boxplot for categorical data, antibiotics vs F331
## 2024-06-26 19:50:27.682942 INFO::Creating boxplot for categorical data, antibiotics vs F757
## 2024-06-26 19:50:27.949256 INFO::Creating boxplot for categorical data, antibiotics vs F167
## 2024-06-26 19:50:28.216168 INFO::Creating boxplot for categorical data, antibiotics vs F85
## 2024-06-26 19:50:28.444988 INFO::Creating boxplot for categorical data, antibiotics vs F80
## 2024-06-26 19:50:28.677743 INFO::Creating boxplot for categorical data, antibiotics vs F105
## 2024-06-26 19:50:28.918199 INFO::Creating boxplot for categorical data, antibiotics vs F674
## 2024-06-26 19:50:29.097013 INFO::Creating boxplot for categorical data, antibiotics vs F50
## 2024-06-26 19:50:29.286363 INFO::Creating boxplot for categorical data, antibiotics vs F164
## 2024-06-26 19:50:29.469528 INFO::Creating boxplot for categorical data, antibiotics vs F840
## 2024-06-26 19:50:29.659951 INFO::Creating boxplot for categorical data, antibiotics vs F232
## 2024-06-26 19:50:29.915071 INFO::Creating boxplot for categorical data, antibiotics vs F872
## 2024-06-26 19:50:30.193134 INFO::Creating boxplot for categorical data, antibiotics vs F54
## 2024-06-26 19:50:30.464454 INFO::Creating boxplot for categorical data, antibiotics vs F365
## 2024-06-26 19:50:30.665968 INFO::Creating boxplot for categorical data, antibiotics vs F499
## 2024-06-26 19:50:30.853846 INFO::Creating boxplot for categorical data, antibiotics vs F510
## 2024-06-26 19:50:31.080085 INFO::Creating boxplot for categorical data, antibiotics vs F716
## 2024-06-26 19:50:31.318834 INFO::Creating boxplot for categorical data, antibiotics vs F454
## 2024-06-26 19:50:31.542471 INFO::Creating boxplot for categorical data, antibiotics vs F52
## 2024-06-26 19:50:31.739579 INFO::Creating boxplot for categorical data, antibiotics vs F273
## 2024-06-26 19:50:31.979685 INFO::Creating boxplot for categorical data, antibiotics vs F474
## 2024-06-26 19:50:32.229888 INFO::Creating boxplot for categorical data, antibiotics vs F267
## 2024-06-26 19:50:32.437247 INFO::Creating boxplot for categorical data, antibiotics vs F253
## 2024-06-26 19:50:32.666467 INFO::Creating boxplot for categorical data, antibiotics vs F247
## 2024-06-26 19:50:32.985604 INFO::Creating boxplot for categorical data, antibiotics vs F708
## 2024-06-26 19:50:33.287981 INFO::Creating boxplot for categorical data, antibiotics vs F438
## 2024-06-26 19:50:33.532634 INFO::Creating boxplot for categorical data, antibiotics vs F450
## 2024-06-26 19:50:33.754121 INFO::Creating boxplot for categorical data, antibiotics vs F666
## 2024-06-26 19:50:34.040368 INFO::Creating boxplot for categorical data, antibiotics vs F720
## 2024-06-26 19:50:34.322009 INFO::Creating boxplot for categorical data, antibiotics vs F48
## 2024-06-26 19:50:34.616472 INFO::Creating boxplot for categorical data, antibiotics vs F371
## 2024-06-26 19:50:34.971532 INFO::Creating boxplot for categorical data, antibiotics vs F423
## 2024-06-26 19:50:35.197482 INFO::Creating boxplot for categorical data, antibiotics vs F190
## 2024-06-26 19:50:35.507066 INFO::Creating boxplot for categorical data, antibiotics vs F351
## 2024-06-26 19:50:35.81202 INFO::Creating boxplot for categorical data, antibiotics vs F394
## 2024-06-26 19:50:36.011145 INFO::Creating boxplot for categorical data, antibiotics vs F581
## 2024-06-26 19:50:36.334 INFO::Creating boxplot for categorical data, antibiotics vs F276
## 2024-06-26 19:50:36.636469 INFO::Creating boxplot for categorical data, antibiotics vs F608
## 2024-06-26 19:50:36.9134 INFO::Creating boxplot for categorical data, antibiotics vs F28
## 2024-06-26 19:50:37.149726 INFO::Creating boxplot for categorical data, antibiotics vs F805
## 2024-06-26 19:50:37.344219 INFO::Creating boxplot for categorical data, antibiotics vs F249
## 2024-06-26 19:50:37.568083 INFO::Creating boxplot for categorical data, antibiotics vs F776
## 2024-06-26 19:50:37.843275 INFO::Creating boxplot for categorical data, antibiotics vs F755
## 2024-06-26 19:50:38.024354 INFO::Creating boxplot for categorical data, antibiotics vs F68
## 2024-06-26 19:50:38.216138 INFO::Creating boxplot for categorical data, antibiotics vs F78
## 2024-06-26 19:50:38.399931 INFO::Creating boxplot for categorical data, antibiotics vs F381
## 2024-06-26 19:50:38.672264 INFO::Creating boxplot for categorical data, antibiotics vs F644
## 2024-06-26 19:50:38.891992 INFO::Creating boxplot for categorical data, antibiotics vs F358
## 2024-06-26 19:50:39.108893 INFO::Creating boxplot for categorical data, antibiotics vs F344
## 2024-06-26 19:50:39.321418 INFO::Creating boxplot for categorical data, antibiotics vs F209
## 2024-06-26 19:50:39.525687 INFO::Creating boxplot for categorical data, antibiotics vs F898
## 2024-06-26 19:50:39.709961 INFO::Creating boxplot for categorical data, antibiotics vs F51
## 2024-06-26 19:50:39.94232 INFO::Creating boxplot for categorical data, antibiotics vs F149
## 2024-06-26 19:50:40.139404 INFO::Creating boxplot for categorical data, antibiotics vs F108
## 2024-06-26 19:50:40.394952 INFO::Creating boxplot for categorical data, antibiotics vs F255
## 2024-06-26 19:50:40.652768 INFO::Creating boxplot for categorical data, antibiotics vs F823
## 2024-06-26 19:50:40.895247 INFO::Creating boxplot for categorical data, antibiotics vs F864
## 2024-06-26 19:50:41.153022 INFO::Creating boxplot for categorical data, antibiotics vs F214
## 2024-06-26 19:50:41.391127 INFO::Creating boxplot for categorical data, antibiotics vs F76
## 2024-06-26 19:50:41.667008 INFO::Creating boxplot for categorical data, antibiotics vs F575
## 2024-06-26 19:50:41.942427 INFO::Creating boxplot for categorical data, antibiotics vs F13
## 2024-06-26 19:50:42.174141 INFO::Creating boxplot for categorical data, antibiotics vs F389
## 2024-06-26 19:50:42.519569 INFO::Creating boxplot for categorical data, antibiotics vs F556
## 2024-06-26 19:50:42.702746 INFO::Creating boxplot for categorical data, antibiotics vs F49
## 2024-06-26 19:50:42.883112 INFO::Creating boxplot for categorical data, antibiotics vs F436
## 2024-06-26 19:50:43.065957 INFO::Creating boxplot for categorical data, antibiotics vs F378
## 2024-06-26 19:50:43.256052 INFO::Creating boxplot for categorical data, antibiotics vs F682
## 2024-06-26 19:50:43.584165 INFO::Creating boxplot for categorical data, antibiotics vs F47
## 2024-06-26 19:50:43.788416 INFO::Creating boxplot for categorical data, antibiotics vs F429
## 2024-06-26 19:50:43.968099 INFO::Creating boxplot for categorical data, antibiotics vs F588
## 2024-06-26 19:50:44.172742 INFO::Creating boxplot for categorical data, antibiotics vs F616
## 2024-06-26 19:50:44.359833 INFO::Creating boxplot for categorical data, antibiotics vs F323
## 2024-06-26 19:50:44.715082 INFO::Creating boxplot for categorical data, antibiotics vs F409
## 2024-06-26 19:50:44.933258 INFO::Creating boxplot for categorical data, antibiotics vs F326
## 2024-06-26 19:50:45.15533 INFO::Creating boxplot for categorical data, antibiotics vs F698
## 2024-06-26 19:50:45.381087 INFO::Creating boxplot for categorical data, antibiotics vs F567
## 2024-06-26 19:50:45.580913 INFO::Creating boxplot for categorical data, antibiotics vs F179
## 2024-06-26 19:50:45.833691 INFO::Creating boxplot for categorical data, antibiotics vs F787
## 2024-06-26 19:50:46.028276 INFO::Creating boxplot for categorical data, antibiotics vs F79
## 2024-06-26 19:50:46.233653 INFO::Creating boxplot for categorical data, antibiotics vs F335
## 2024-06-26 19:50:46.428517 INFO::Creating boxplot for categorical data, antibiotics vs F576
## 2024-06-26 19:50:46.683035 INFO::Creating boxplot for categorical data, antibiotics vs F667
## 2024-06-26 19:50:47.053342 INFO::Creating boxplot for categorical data, antibiotics vs F694
## 2024-06-26 19:50:47.295598 INFO::Creating boxplot for categorical data, antibiotics vs F297
## 2024-06-26 19:50:47.575334 INFO::Creating boxplot for categorical data, antibiotics vs F569
## 2024-06-26 19:50:47.89256 INFO::Creating boxplot for categorical data, antibiotics vs F138
## 2024-06-26 19:50:48.08273 INFO::Creating boxplot for categorical data, antibiotics vs F611
## 2024-06-26 19:50:48.342718 INFO::Creating boxplot for categorical data, antibiotics vs F810
## 2024-06-26 19:50:48.5549 INFO::Creating boxplot for categorical data, antibiotics vs F746
## 2024-06-26 19:50:48.762881 INFO::Creating boxplot for categorical data, antibiotics vs F23
## 2024-06-26 19:50:48.987643 INFO::Creating boxplot for categorical data, antibiotics vs F135
## 2024-06-26 19:50:49.312949 INFO::Creating boxplot for categorical data, antibiotics vs F411
## 2024-06-26 19:50:49.675535 INFO::Creating boxplot for categorical data, antibiotics vs F489
## 2024-06-26 19:50:50.000166 INFO::Creating boxplot for categorical data, antibiotics vs F492
## 2024-06-26 19:50:50.249374 INFO::Creating boxplot for categorical data, antibiotics vs F844
## 2024-06-26 19:50:50.539761 INFO::Creating boxplot for categorical data, antibiotics vs F586
## 2024-06-26 19:50:50.75395 INFO::Creating boxplot for categorical data, antibiotics vs F11
## 2024-06-26 19:50:50.975092 INFO::Creating boxplot for categorical data, antibiotics vs F900
## 2024-06-26 19:50:51.216014 INFO::Creating boxplot for categorical data, antibiotics vs F21
## 2024-06-26 19:50:51.441659 INFO::Creating boxplot for categorical data, antibiotics vs F736
## 2024-06-26 19:50:51.647833 INFO::Creating boxplot for categorical data, antibiotics vs F408
## 2024-06-26 19:50:51.831161 INFO::Creating boxplot for categorical data, antibiotics vs F788
## 2024-06-26 19:50:52.017474 INFO::Creating boxplot for categorical data, antibiotics vs F66
## 2024-06-26 19:50:52.254479 INFO::Creating boxplot for categorical data, antibiotics vs F493
## 2024-06-26 19:50:52.480224 INFO::Creating boxplot for categorical data, antibiotics vs F343
## 2024-06-26 19:50:52.810758 INFO::Creating boxplot for categorical data, antibiotics vs F352
## 2024-06-26 19:50:53.040539 INFO::Creating boxplot for categorical data, antibiotics vs F677
## 2024-06-26 19:50:53.253759 INFO::Creating boxplot for categorical data, antibiotics vs F816
## 2024-06-26 19:50:53.56878 INFO::Creating boxplot for categorical data, antibiotics vs F457
## 2024-06-26 19:50:53.802287 INFO::Creating boxplot for categorical data, antibiotics vs F330
## 2024-06-26 19:50:53.990988 INFO::Creating boxplot for categorical data, antibiotics vs F293
## 2024-06-26 19:50:54.170358 INFO::Creating boxplot for categorical data, antibiotics vs F725
## 2024-06-26 19:50:54.410641 INFO::Creating boxplot for categorical data, antibiotics vs F813
## 2024-06-26 19:50:54.677568 INFO::Creating boxplot for categorical data, antibiotics vs F295
## 2024-06-26 19:50:54.872418 INFO::Creating boxplot for categorical data, antibiotics vs F656
## 2024-06-26 19:50:55.063726 INFO::Creating boxplot for categorical data, antibiotics vs F669
## 2024-06-26 19:50:55.268529 INFO::Creating boxplot for categorical data, antibiotics vs F15
## 2024-06-26 19:50:55.462273 INFO::Creating boxplot for categorical data, antibiotics vs F419
## 2024-06-26 19:50:55.674428 INFO::Creating boxplot for categorical data, antibiotics vs F701
## 2024-06-26 19:50:55.865826 INFO::Creating boxplot for categorical data, antibiotics vs F176
## 2024-06-26 19:50:56.052811 INFO::Creating boxplot for categorical data, antibiotics vs F203
## 2024-06-26 19:50:56.249369 INFO::Creating boxplot for categorical data, antibiotics vs F501
## 2024-06-26 19:50:56.436934 INFO::Creating boxplot for categorical data, antibiotics vs F772
## 2024-06-26 19:50:56.673633 INFO::Creating boxplot for categorical data, antibiotics vs F488
## 2024-06-26 19:50:56.948509 INFO::Creating boxplot for categorical data, antibiotics vs F600
## 2024-06-26 19:50:57.228542 INFO::Creating boxplot for categorical data, antibiotics vs F768
## 2024-06-26 19:50:57.516624 INFO::Creating boxplot for categorical data, antibiotics vs F432
## 2024-06-26 19:50:57.70412 INFO::Creating boxplot for categorical data, antibiotics vs F26
## 2024-06-26 19:50:57.894465 INFO::Creating boxplot for categorical data, antibiotics vs F189
## 2024-06-26 19:50:58.107723 INFO::Creating boxplot for categorical data, antibiotics vs F200
## 2024-06-26 19:50:58.342809 INFO::Creating boxplot for categorical data, antibiotics vs F121
## 2024-06-26 19:50:58.62123 INFO::Creating boxplot for categorical data, antibiotics vs F624
## 2024-06-26 19:50:58.891809 INFO::Creating boxplot for categorical data, antibiotics vs F855
## 2024-06-26 19:50:59.0733 INFO::Creating boxplot for categorical data, antibiotics vs F380
## 2024-06-26 19:50:59.287058 INFO::Creating boxplot for categorical data, antibiotics vs F734
## 2024-06-26 19:50:59.471296 INFO::Creating boxplot for categorical data, antibiotics vs F16
## 2024-06-26 19:50:59.664007 INFO::Creating boxplot for categorical data, antibiotics vs F602
## 2024-06-26 19:50:59.87767 INFO::Creating boxplot for categorical data, antibiotics vs F210
## 2024-06-26 19:51:00.19184 INFO::Creating boxplot for categorical data, antibiotics vs F217
## 2024-06-26 19:51:00.551402 INFO::Creating boxplot for categorical data, antibiotics vs F640
## 2024-06-26 19:51:00.83642 INFO::Creating boxplot for categorical data, antibiotics vs F631
## 2024-06-26 19:51:01.109519 INFO::Creating boxplot for categorical data, antibiotics vs F32
## 2024-06-26 19:51:01.298389 INFO::Creating boxplot for categorical data, antibiotics vs F322
## 2024-06-26 19:51:01.475254 INFO::Creating boxplot for categorical data, antibiotics vs F476
## 2024-06-26 19:51:01.734836 INFO::Creating boxplot for categorical data, antibiotics vs F265
## 2024-06-26 19:51:01.976542 INFO::Creating boxplot for categorical data, antibiotics vs F283
## 2024-06-26 19:51:02.263323 INFO::Creating boxplot for categorical data, antibiotics vs F316
## 2024-06-26 19:51:02.542928 INFO::Creating boxplot for categorical data, antibiotics vs F465
## 2024-06-26 19:51:02.736961 INFO::Creating boxplot for categorical data, antibiotics vs F24
## 2024-06-26 19:51:02.993575 INFO::Creating boxplot for categorical data, antibiotics vs F38
## 2024-06-26 19:51:03.320903 INFO::Creating boxplot for categorical data, antibiotics vs F82
## 2024-06-26 19:51:03.531479 INFO::Creating boxplot for categorical data, antibiotics vs F86
## 2024-06-26 19:51:03.728917 INFO::Creating boxplot for categorical data, antibiotics vs F270
## 2024-06-26 19:51:03.926172 INFO::Creating boxplot for categorical data, antibiotics vs F485
## 2024-06-26 19:51:04.15676 INFO::Creating boxplot for categorical data, antibiotics vs F486
## 2024-06-26 19:51:04.364564 INFO::Creating boxplot for categorical data, antibiotics vs F399
## 2024-06-26 19:51:04.574758 INFO::Creating boxplot for categorical data, antibiotics vs F573
## 2024-06-26 19:51:04.83783 INFO::Creating boxplot for categorical data, antibiotics vs F877
## 2024-06-26 19:51:05.073389 INFO::Creating boxplot for categorical data, antibiotics vs F709
## 2024-06-26 19:51:05.347774 INFO::Creating boxplot for categorical data, antibiotics vs F227
## 2024-06-26 19:51:05.586184 INFO::Creating boxplot for categorical data, antibiotics vs F553
## 2024-06-26 19:51:05.810551 INFO::Creating boxplot for categorical data, antibiotics vs F123
## 2024-06-26 19:51:06.022222 INFO::Creating boxplot for categorical data, antibiotics vs F118
## 2024-06-26 19:51:06.308223 INFO::Creating boxplot for categorical data, antibiotics vs F605
## 2024-06-26 19:51:06.502666 INFO::Creating boxplot for categorical data, antibiotics vs F619
## 2024-06-26 19:51:06.722532 INFO::Creating boxplot for categorical data, antibiotics vs F830
## 2024-06-26 19:51:06.971934 INFO::Creating boxplot for categorical data, antibiotics vs F837
## 2024-06-26 19:51:07.290064 INFO::Creating boxplot for categorical data, antibiotics vs F12
## 2024-06-26 19:51:07.535901 INFO::Creating boxplot for categorical data, antibiotics vs F623
## 2024-06-26 19:51:07.849708 INFO::Creating boxplot for categorical data, antibiotics vs F806
## 2024-06-26 19:51:08.129926 INFO::Creating boxplot for categorical data, antibiotics vs F353
## 2024-06-26 19:51:08.353002 INFO::Creating boxplot for categorical data, antibiotics vs F829
## 2024-06-26 19:51:08.54408 INFO::Creating boxplot for categorical data, antibiotics vs F289
## 2024-06-26 19:51:08.742459 INFO::Creating boxplot for categorical data, antibiotics vs F93
## 2024-06-26 19:51:09.040985 INFO::Creating boxplot for categorical data, antibiotics vs F379
## 2024-06-26 19:51:09.327593 INFO::Creating boxplot for categorical data, antibiotics vs F370
## 2024-06-26 19:51:09.536506 INFO::Creating boxplot for categorical data, antibiotics vs F360
## 2024-06-26 19:51:09.741683 INFO::Creating boxplot for categorical data, antibiotics vs F710
## 2024-06-26 19:51:09.938011 INFO::Creating boxplot for categorical data, antibiotics vs F388
## 2024-06-26 19:51:10.133666 INFO::Creating boxplot for categorical data, antibiotics vs F796
## 2024-06-26 19:51:10.434718 INFO::Creating boxplot for categorical data, antibiotics vs F174
## 2024-06-26 19:51:10.721725 INFO::Creating boxplot for categorical data, antibiotics vs F601
## 2024-06-26 19:51:10.962031 INFO::Creating boxplot for categorical data, antibiotics vs F775
## 2024-06-26 19:51:11.212439 INFO::Creating boxplot for categorical data, antibiotics vs F836
## 2024-06-26 19:51:11.429964 INFO::Creating boxplot for categorical data, antibiotics vs F192
## 2024-06-26 19:51:11.655575 INFO::Creating boxplot for categorical data, antibiotics vs F463
## 2024-06-26 19:51:11.946552 INFO::Creating boxplot for categorical data, antibiotics vs F57
## 2024-06-26 19:51:12.260848 INFO::Creating boxplot for categorical data, antibiotics vs F658
## 2024-06-26 19:51:12.56702 INFO::Creating boxplot for categorical data, antibiotics vs F596
## 2024-06-26 19:51:12.871767 INFO::Creating boxplot for categorical data, antibiotics vs F218
## 2024-06-26 19:51:13.21968 INFO::Creating boxplot for categorical data, antibiotics vs F104
## 2024-06-26 19:51:13.526387 INFO::Creating boxplot for categorical data, antibiotics vs F466
## 2024-06-26 19:51:13.782715 INFO::Creating boxplot for categorical data, antibiotics vs F737
## 2024-06-26 19:51:14.084532 INFO::Creating boxplot for categorical data, antibiotics vs F487
## 2024-06-26 19:51:14.372237 INFO::Creating boxplot for categorical data, antibiotics vs F369
## 2024-06-26 19:51:14.629664 INFO::Creating boxplot for categorical data, antibiotics vs F584
## 2024-06-26 19:51:14.933128 INFO::Creating boxplot for categorical data, antibiotics vs F166
## 2024-06-26 19:51:15.232842 INFO::Creating boxplot for categorical data, antibiotics vs F822
## 2024-06-26 19:51:15.520912 INFO::Creating boxplot for categorical data, antibiotics vs F416
## 2024-06-26 19:51:15.804725 INFO::Creating boxplot for categorical data, antibiotics vs F70
## 2024-06-26 19:51:16.074517 INFO::Creating boxplot for categorical data, antibiotics vs F243
## 2024-06-26 19:51:16.370897 INFO::Creating boxplot for categorical data, antibiotics vs F498
## 2024-06-26 19:51:16.701186 INFO::Creating boxplot for categorical data, antibiotics vs F272
## 2024-06-26 19:51:16.979862 INFO::Creating boxplot for categorical data, antibiotics vs F846
## 2024-06-26 19:51:17.249305 INFO::Creating boxplot for categorical data, antibiotics vs F881
## 2024-06-26 19:51:17.499213 INFO::Creating boxplot for categorical data, antibiotics vs F280
## 2024-06-26 19:51:17.845167 INFO::Creating boxplot for categorical data, antibiotics vs F761
## 2024-06-26 19:51:18.066777 INFO::Creating boxplot for categorical data, antibiotics vs F781
## 2024-06-26 19:51:18.363212 INFO::Creating boxplot for categorical data, antibiotics vs F697
## 2024-06-26 19:51:18.560307 INFO::Creating boxplot for categorical data, antibiotics vs F890
## 2024-06-26 19:51:18.766852 INFO::Creating boxplot for categorical data, antibiotics vs F197
## 2024-06-26 19:51:19.118611 INFO::Creating boxplot for categorical data, antibiotics vs F826
## 2024-06-26 19:51:19.343182 INFO::Creating boxplot for categorical data, antibiotics vs F641
## 2024-06-26 19:51:19.622147 INFO::Creating boxplot for categorical data, antibiotics vs F700
## 2024-06-26 19:51:19.905871 INFO::Creating boxplot for categorical data, antibiotics vs F531
## 2024-06-26 19:51:20.125078 INFO::Creating boxplot for categorical data, antibiotics vs F660
## 2024-06-26 19:51:20.433797 INFO::Creating boxplot for categorical data, antibiotics vs F257
## 2024-06-26 19:51:20.760384 INFO::Creating boxplot for categorical data, antibiotics vs F136
## 2024-06-26 19:51:20.966833 INFO::Creating boxplot for categorical data, antibiotics vs F875
## 2024-06-26 19:51:21.180616 INFO::Creating boxplot for categorical data, antibiotics vs F160
## 2024-06-26 19:51:21.403741 INFO::Creating boxplot for categorical data, antibiotics vs F782
## 2024-06-26 19:51:21.744291 INFO::Creating boxplot for categorical data, antibiotics vs F642
## 2024-06-26 19:51:22.052959 INFO::Creating boxplot for categorical data, antibiotics vs F730
## 2024-06-26 19:51:22.365331 INFO::Creating boxplot for categorical data, antibiotics vs F679
## 2024-06-26 19:51:22.568502 INFO::Creating boxplot for categorical data, antibiotics vs F713
## 2024-06-26 19:51:22.825972 INFO::Creating boxplot for categorical data, antibiotics vs F821
## 2024-06-26 19:51:23.13644 INFO::Creating boxplot for categorical data, antibiotics vs F443
## 2024-06-26 19:51:23.385408 INFO::Creating boxplot for categorical data, antibiotics vs F729
## 2024-06-26 19:51:23.679891 INFO::Creating boxplot for categorical data, antibiotics vs F25
## 2024-06-26 19:51:24.01752 INFO::Creating boxplot for categorical data, antibiotics vs F338
## 2024-06-26 19:51:24.329204 INFO::Creating boxplot for categorical data, antibiotics vs F647
## 2024-06-26 19:51:24.599556 INFO::Creating boxplot for categorical data, antibiotics vs F817
## 2024-06-26 19:51:24.864889 INFO::Creating boxplot for categorical data, antibiotics vs F535
## 2024-06-26 19:51:25.074745 INFO::Creating boxplot for categorical data, antibiotics vs F634
## 2024-06-26 19:51:25.323952 INFO::Creating boxplot for categorical data, antibiotics vs F533
## 2024-06-26 19:51:25.613436 INFO::Creating boxplot for categorical data, antibiotics vs F808
## 2024-06-26 19:51:25.849117 INFO::Creating boxplot for categorical data, antibiotics vs F571
## 2024-06-26 19:51:26.13157 INFO::Creating boxplot for categorical data, antibiotics vs F529
## 2024-06-26 19:51:26.43873 INFO::Creating boxplot for categorical data, antibiotics vs F827
## 2024-06-26 19:51:26.719092 INFO::Creating boxplot for categorical data, antibiotics vs F107
## 2024-06-26 19:51:27.015597 INFO::Creating boxplot for categorical data, antibiotics vs F515
## 2024-06-26 19:51:27.218337 INFO::Creating boxplot for categorical data, antibiotics vs F305
## 2024-06-26 19:51:27.496735 INFO::Creating boxplot for categorical data, antibiotics vs F662
## 2024-06-26 19:51:27.69761 INFO::Creating boxplot for categorical data, antibiotics vs F310
## 2024-06-26 19:51:27.928526 INFO::Creating boxplot for categorical data, antibiotics vs F430
## 2024-06-26 19:51:28.154521 INFO::Creating boxplot for categorical data, antibiotics vs F173
## 2024-06-26 19:51:28.3774 INFO::Creating boxplot for categorical data, antibiotics vs F820
## 2024-06-26 19:51:28.667133 INFO::Creating boxplot for categorical data, antibiotics vs F743
## 2024-06-26 19:51:28.969653 INFO::Creating boxplot for categorical data, antibiotics vs F63
## 2024-06-26 19:51:29.179527 INFO::Creating boxplot for categorical data, antibiotics vs F215
## 2024-06-26 19:51:29.361666 INFO::Creating boxplot for categorical data, antibiotics vs F216
## 2024-06-26 19:51:29.540314 INFO::Creating boxplot for categorical data, antibiotics vs F245
## 2024-06-26 19:51:29.768077 INFO::Creating boxplot for categorical data, antibiotics vs F862
## 2024-06-26 19:51:29.956903 INFO::Creating boxplot for categorical data, antibiotics vs F541
## 2024-06-26 19:51:30.149167 INFO::Creating boxplot for categorical data, antibiotics vs F558
## 2024-06-26 19:51:30.360074 INFO::Creating boxplot for categorical data, antibiotics vs F633
## 2024-06-26 19:51:30.608358 INFO::Creating boxplot for categorical data, antibiotics vs F94
## 2024-06-26 19:51:30.851403 INFO::Creating boxplot for categorical data, antibiotics vs F574
## 2024-06-26 19:51:31.041386 INFO::Creating boxplot for categorical data, antibiotics vs F238
## 2024-06-26 19:51:31.271475 INFO::Creating boxplot for categorical data, antibiotics vs F815
## 2024-06-26 19:51:31.512066 INFO::Creating boxplot for categorical data, antibiotics vs F587
## 2024-06-26 19:51:31.822607 INFO::Creating boxplot for categorical data, antibiotics vs F464
## 2024-06-26 19:51:32.137967 INFO::Creating boxplot for categorical data, antibiotics vs F590
## 2024-06-26 19:51:32.444731 INFO::Creating boxplot for categorical data, antibiotics vs F124
## 2024-06-26 19:51:32.703403 INFO::Creating boxplot for categorical data, antibiotics vs F664
## 2024-06-26 19:51:32.948749 INFO::Creating boxplot for categorical data, antibiotics vs F100
## 2024-06-26 19:51:33.181242 INFO::Creating boxplot for categorical data, antibiotics vs F744
## 2024-06-26 19:51:33.487973 INFO::Creating boxplot for categorical data, antibiotics vs F444
## 2024-06-26 19:51:33.845178 INFO::Creating boxplot for categorical data, antibiotics vs F597
## 2024-06-26 19:51:34.065134 INFO::Creating boxplot for categorical data, antibiotics vs F650
## 2024-06-26 19:51:34.302534 INFO::Creating boxplot for categorical data, antibiotics vs F147
## 2024-06-26 19:51:34.589793 INFO::Creating boxplot for categorical data, antibiotics vs F363
## 2024-06-26 19:51:34.840823 INFO::Creating boxplot for categorical data, antibiotics vs F521
## 2024-06-26 19:51:35.067388 INFO::Creating boxplot for categorical data, antibiotics vs F412
## 2024-06-26 19:51:35.27738 INFO::Creating boxplot for categorical data, antibiotics vs F279
## 2024-06-26 19:51:35.591843 INFO::Creating boxplot for categorical data, antibiotics vs F225
## 2024-06-26 19:51:35.878426 INFO::Creating boxplot for categorical data, antibiotics vs F10
## 2024-06-26 19:51:36.223336 INFO::Creating boxplot for categorical data, antibiotics vs F481
## 2024-06-26 19:51:36.561254 INFO::Creating boxplot for categorical data, antibiotics vs F861
## 2024-06-26 19:51:36.877035 INFO::Creating boxplot for categorical data, antibiotics vs F888
## 2024-06-26 19:51:37.192983 INFO::Creating boxplot for categorical data, antibiotics vs F156
## 2024-06-26 19:51:37.478415 INFO::Creating boxplot for categorical data, antibiotics vs F857
## 2024-06-26 19:51:37.769949 INFO::Creating boxplot for categorical data, antibiotics vs F509
## 2024-06-26 19:51:38.025014 INFO::Creating boxplot for categorical data, antibiotics vs F244
## 2024-06-26 19:51:38.325479 INFO::Creating boxplot for categorical data, antibiotics vs F514
## 2024-06-26 19:51:38.585037 INFO::Creating boxplot for categorical data, antibiotics vs F196
## 2024-06-26 19:51:38.773659 INFO::Creating boxplot for categorical data, antibiotics vs F304
## 2024-06-26 19:51:38.988351 INFO::Creating boxplot for categorical data, antibiotics vs F833
## 2024-06-26 19:51:39.266095 INFO::Creating boxplot for categorical data, antibiotics vs F294
## 2024-06-26 19:51:39.574967 INFO::Creating boxplot for categorical data, antibiotics vs F550
## 2024-06-26 19:51:39.879105 INFO::Creating boxplot for categorical data, antibiotics vs F869
## 2024-06-26 19:51:40.174193 INFO::Creating boxplot for categorical data, antibiotics vs F364
## 2024-06-26 19:51:40.47248 INFO::Creating boxplot for categorical data, antibiotics vs F583
## 2024-06-26 19:51:40.818827 INFO::Creating boxplot for categorical data, antibiotics vs F441
## 2024-06-26 19:51:41.040551 INFO::Creating boxplot for categorical data, antibiotics vs F595
## 2024-06-26 19:51:41.331511 INFO::Creating boxplot for categorical data, antibiotics vs F35
## 2024-06-26 19:51:41.581456 INFO::Creating boxplot for categorical data, antibiotics vs F630
## 2024-06-26 19:51:41.766579 INFO::Creating boxplot for categorical data, antibiotics vs F401
## 2024-06-26 19:51:42.107166 INFO::Creating boxplot for categorical data, antibiotics vs F287
## 2024-06-26 19:51:42.425062 INFO::Creating boxplot for categorical data, antibiotics vs F250
## 2024-06-26 19:51:42.733547 INFO::Creating boxplot for categorical data, antibiotics vs F239
## 2024-06-26 19:51:42.981577 INFO::Creating boxplot for categorical data, antibiotics vs F88
## 2024-06-26 19:51:43.16578 INFO::Creating boxplot for categorical data, antibiotics vs F752
## 2024-06-26 19:51:43.396753 INFO::Creating boxplot for categorical data, antibiotics vs F539
## 2024-06-26 19:51:43.590113 INFO::Creating boxplot for categorical data, antibiotics vs F69
## 2024-06-26 19:51:43.791471 INFO::Creating boxplot for categorical data, antibiotics vs F126
## 2024-06-26 19:51:43.992188 INFO::Creating boxplot for categorical data, antibiotics vs F362
## 2024-06-26 19:51:44.185317 INFO::Creating boxplot for categorical data, antibiotics vs F753
## 2024-06-26 19:51:44.431295 INFO::Creating boxplot for categorical data, antibiotics vs F469
## 2024-06-26 19:51:44.656126 INFO::Creating boxplot for categorical data, antibiotics vs F14
## 2024-06-26 19:51:44.870247 INFO::Creating boxplot for categorical data, antibiotics vs F803
## 2024-06-26 19:51:45.07832 INFO::Creating boxplot for categorical data, antibiotics vs F814
## 2024-06-26 19:51:45.299773 INFO::Creating boxplot for categorical data, antibiotics vs F449
## 2024-06-26 19:51:45.548728 INFO::Creating boxplot for categorical data, antibiotics vs F494
## 2024-06-26 19:51:45.749002 INFO::Creating boxplot for categorical data, antibiotics vs F439
## 2024-06-26 19:51:45.954384 INFO::Creating boxplot for categorical data, antibiotics vs F686
## 2024-06-26 19:51:46.155964 INFO::Creating boxplot for categorical data, antibiotics vs F591
## 2024-06-26 19:51:46.35898 INFO::Creating boxplot for categorical data, antibiotics vs F735
## 2024-06-26 19:51:46.543195 INFO::Creating boxplot for categorical data, antibiotics vs F111
## 2024-06-26 19:51:46.776872 INFO::Creating boxplot for categorical data, antibiotics vs F346
## 2024-06-26 19:51:46.979098 INFO::Creating boxplot for categorical data, antibiotics vs F29
## 2024-06-26 19:51:47.186729 INFO::Creating boxplot for categorical data, antibiotics vs F376
## 2024-06-26 19:51:47.384679 INFO::Creating boxplot for categorical data, antibiotics vs F414
## 2024-06-26 19:51:47.703482 INFO::Creating boxplot for categorical data, antibiotics vs F555
## 2024-06-26 19:51:48.013255 INFO::Creating boxplot for categorical data, antibiotics vs F517
## 2024-06-26 19:51:48.242713 INFO::Creating boxplot for categorical data, antibiotics vs F544
## 2024-06-26 19:51:48.445798 INFO::Creating boxplot for categorical data, antibiotics vs F339
## 2024-06-26 19:51:48.64807 INFO::Creating boxplot for categorical data, antibiotics vs F689
## 2024-06-26 19:51:48.89797 INFO::Creating boxplot for categorical data, antibiotics vs F391
## 2024-06-26 19:51:49.194199 INFO::Creating boxplot for categorical data, antibiotics vs F502
## 2024-06-26 19:51:49.397723 INFO::Creating boxplot for categorical data, antibiotics vs F298
## 2024-06-26 19:51:49.622006 INFO::Creating boxplot for categorical data, antibiotics vs F337
## 2024-06-26 19:51:49.88015 INFO::Creating boxplot for categorical data, antibiotics vs F773
## 2024-06-26 19:51:50.110334 INFO::Creating boxplot for categorical data, antibiotics vs F592
## 2024-06-26 19:51:50.391134 INFO::Creating boxplot for categorical data, antibiotics vs F307
## 2024-06-26 19:51:50.577481 INFO::Creating boxplot for categorical data, antibiotics vs F115
## 2024-06-26 19:51:50.932965 INFO::Creating boxplot for categorical data, antibiotics vs F739
## 2024-06-26 19:51:51.286516 INFO::Creating boxplot for categorical data, antibiotics vs F433
## 2024-06-26 19:51:51.62923 INFO::Creating boxplot for categorical data, antibiotics vs F384
## 2024-06-26 19:51:52.017494 INFO::Creating boxplot for categorical data, antibiotics vs F750
## 2024-06-26 19:51:52.361758 INFO::Creating boxplot for categorical data, antibiotics vs F762
## 2024-06-26 19:51:52.63194 INFO::Creating boxplot for categorical data, antibiotics vs F277
## 2024-06-26 19:51:52.826634 INFO::Creating boxplot for categorical data, antibiotics vs F871
## 2024-06-26 19:51:53.047381 INFO::Creating boxplot for categorical data, antibiotics vs F839
## 2024-06-26 19:51:53.343013 INFO::Creating boxplot for categorical data, antibiotics vs F127
## 2024-06-26 19:51:53.671296 INFO::Creating boxplot for categorical data, antibiotics vs F554
## 2024-06-26 19:51:53.994531 INFO::Creating boxplot for categorical data, antibiotics vs F676
## 2024-06-26 19:51:54.275822 INFO::Creating boxplot for categorical data, antibiotics vs F568
## 2024-06-26 19:51:54.480457 INFO::Creating boxplot for categorical data, antibiotics vs F137
## 2024-06-26 19:51:54.678128 INFO::Creating boxplot for categorical data, antibiotics vs F131
## 2024-06-26 19:51:54.937562 INFO::Creating boxplot for categorical data, antibiotics vs F60
## 2024-06-26 19:51:55.15048 INFO::Creating boxplot for categorical data, antibiotics vs F98
## 2024-06-26 19:51:55.382437 INFO::Creating boxplot for categorical data, antibiotics vs F672
## 2024-06-26 19:51:55.599582 INFO::Creating boxplot for categorical data, antibiotics vs F530
## 2024-06-26 19:51:55.847765 INFO::Creating boxplot for categorical data, antibiotics vs F809
## 2024-06-26 19:51:56.193003 INFO::Creating boxplot for categorical data, antibiotics vs F894
## 2024-06-26 19:51:56.410466 INFO::Creating boxplot for categorical data, antibiotics vs F22
## 2024-06-26 19:51:56.610325 INFO::Creating boxplot for categorical data, antibiotics vs F818
## 2024-06-26 19:51:56.811283 INFO::Creating boxplot for categorical data, antibiotics vs F559
## 2024-06-26 19:51:57.002336 INFO::Creating boxplot for categorical data, antibiotics vs F741
## 2024-06-26 19:51:57.252854 INFO::Creating boxplot for categorical data, antibiotics vs F398
## 2024-06-26 19:51:57.465456 INFO::Creating boxplot for categorical data, antibiotics vs F357
## 2024-06-26 19:51:57.670013 INFO::Creating boxplot for categorical data, antibiotics vs F119
## 2024-06-26 19:51:57.861479 INFO::Creating boxplot for categorical data, antibiotics vs F426
## 2024-06-26 19:51:58.064406 INFO::Creating boxplot for categorical data, antibiotics vs F204
## 2024-06-26 19:51:58.391898 INFO::Creating boxplot for categorical data, antibiotics vs F851
## 2024-06-26 19:51:58.611637 INFO::Creating boxplot for categorical data, antibiotics vs F657
## 2024-06-26 19:51:58.867488 INFO::Creating boxplot for categorical data, antibiotics vs F801
## 2024-06-26 19:51:59.141905 INFO::Creating boxplot for categorical data, antibiotics vs F754
## 2024-06-26 19:51:59.415734 INFO::Creating boxplot for categorical data, antibiotics vs F859
## 2024-06-26 19:51:59.7901 INFO::Creating boxplot for categorical data, antibiotics vs F480
## 2024-06-26 19:52:00.002085 INFO::Creating boxplot for categorical data, antibiotics vs F507
## 2024-06-26 19:52:00.282312 INFO::Creating boxplot for categorical data, antibiotics vs F207
## 2024-06-26 19:52:03.294113 INFO::Plotting data for metadata number 3, age
## 2024-06-26 19:52:03.299272 INFO::Creating scatter plot for continuous data, age vs F340
## `geom_smooth()` using formula = 'y ~ x'
## 2024-06-26 19:52:03.597146 INFO::Creating scatter plot for continuous data, age vs F603
## `geom_smooth()` using formula = 'y ~ x'
## 2024-06-26 19:52:04.005195 INFO::Creating scatter plot for continuous data, age vs F356
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:04.304892 INFO::Creating scatter plot for continuous data, age vs F181
## `geom_smooth()` using formula = 'y ~ x'
## 2024-06-26 19:52:04.506839 INFO::Creating scatter plot for continuous data, age vs F177
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:04.730203 INFO::Creating scatter plot for continuous data, age vs F390
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:04.979059 INFO::Creating scatter plot for continuous data, age vs F743
## `geom_smooth()` using formula = 'y ~ x'
## 2024-06-26 19:52:05.32394 INFO::Creating scatter plot for continuous data, age vs F491
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:05.555649 INFO::Creating scatter plot for continuous data, age vs F436
## `geom_smooth()` using formula = 'y ~ x'
## 2024-06-26 19:52:05.763474 INFO::Creating scatter plot for continuous data, age vs F219
## `geom_smooth()` using formula = 'y ~ x'
## 2024-06-26 19:52:05.957851 INFO::Creating scatter plot for continuous data, age vs F483
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:06.214033 INFO::Creating scatter plot for continuous data, age vs F878
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:06.477848 INFO::Creating scatter plot for continuous data, age vs F876
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:06.676456 INFO::Creating scatter plot for continuous data, age vs F211
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:06.91607 INFO::Creating scatter plot for continuous data, age vs F732
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:07.247312 INFO::Creating scatter plot for continuous data, age vs F222
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:07.538831 INFO::Creating scatter plot for continuous data, age vs F688
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:07.740271 INFO::Creating scatter plot for continuous data, age vs F170
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:08.016628 INFO::Creating scatter plot for continuous data, age vs F431
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:08.282145 INFO::Creating scatter plot for continuous data, age vs F174
## `geom_smooth()` using formula = 'y ~ x'
## 2024-06-26 19:52:09.671514 INFO::Creating scatter plot for continuous data, age vs F17
## `geom_smooth()` using formula = 'y ~ x'
## 2024-06-26 19:52:09.969377 INFO::Creating scatter plot for continuous data, age vs F334
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:10.21641 INFO::Creating scatter plot for continuous data, age vs F835
## `geom_smooth()` using formula = 'y ~ x'
## 2024-06-26 19:52:10.404798 INFO::Creating scatter plot for continuous data, age vs F223
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:10.633493 INFO::Creating scatter plot for continuous data, age vs F383
## `geom_smooth()` using formula = 'y ~ x'
## 2024-06-26 19:52:10.843425 INFO::Creating scatter plot for continuous data, age vs F623
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:11.053079 INFO::Creating scatter plot for continuous data, age vs F329
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:11.243122 INFO::Creating scatter plot for continuous data, age vs F395
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:11.512474 INFO::Creating scatter plot for continuous data, age vs F528
## `geom_smooth()` using formula = 'y ~ x'
## 2024-06-26 19:52:11.72255 INFO::Creating scatter plot for continuous data, age vs F13
## `geom_smooth()` using formula = 'y ~ x'
## 2024-06-26 19:52:11.918188 INFO::Creating scatter plot for continuous data, age vs F36
## `geom_smooth()` using formula = 'y ~ x'
## 2024-06-26 19:52:12.140047 INFO::Creating scatter plot for continuous data, age vs F285
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:12.41643 INFO::Creating scatter plot for continuous data, age vs F404
## `geom_smooth()` using formula = 'y ~ x'
## 2024-06-26 19:52:12.618482 INFO::Creating scatter plot for continuous data, age vs F894
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:12.829772 INFO::Creating scatter plot for continuous data, age vs F300
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:13.065206 INFO::Creating scatter plot for continuous data, age vs F32
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:13.318855 INFO::Creating scatter plot for continuous data, age vs F24
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:13.570483 INFO::Creating scatter plot for continuous data, age vs F97
## `geom_smooth()` using formula = 'y ~ x'
## 2024-06-26 19:52:13.784734 INFO::Creating scatter plot for continuous data, age vs F849
## `geom_smooth()` using formula = 'y ~ x'
## 2024-06-26 19:52:14.066919 INFO::Creating scatter plot for continuous data, age vs F185
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:14.287677 INFO::Creating scatter plot for continuous data, age vs F513
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:14.543545 INFO::Creating scatter plot for continuous data, age vs F296
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:14.819985 INFO::Creating scatter plot for continuous data, age vs F471
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:15.093402 INFO::Creating scatter plot for continuous data, age vs F793
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:15.38601 INFO::Creating scatter plot for continuous data, age vs F402
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:15.65691 INFO::Creating scatter plot for continuous data, age vs F541
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:15.937112 INFO::Creating scatter plot for continuous data, age vs F496
## `geom_smooth()` using formula = 'y ~ x'
## 2024-06-26 19:52:16.119605 INFO::Creating scatter plot for continuous data, age vs F386
## `geom_smooth()` using formula = 'y ~ x'
## 2024-06-26 19:52:16.359638 INFO::Creating scatter plot for continuous data, age vs F594
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:16.664432 INFO::Creating scatter plot for continuous data, age vs F704
## `geom_smooth()` using formula = 'y ~ x'
## 2024-06-26 19:52:16.909167 INFO::Creating scatter plot for continuous data, age vs F330
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:17.165082 INFO::Creating scatter plot for continuous data, age vs F197
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:17.362991 INFO::Creating scatter plot for continuous data, age vs F735
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:17.58322 INFO::Creating scatter plot for continuous data, age vs F481
## `geom_smooth()` using formula = 'y ~ x'
## 2024-06-26 19:52:17.756893 INFO::Creating scatter plot for continuous data, age vs F635
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:18.03941 INFO::Creating scatter plot for continuous data, age vs F687
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:18.351213 INFO::Creating scatter plot for continuous data, age vs F652
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:18.663259 INFO::Creating scatter plot for continuous data, age vs F651
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:18.910987 INFO::Creating scatter plot for continuous data, age vs F82
## `geom_smooth()` using formula = 'y ~ x'
## 2024-06-26 19:52:19.094038 INFO::Creating scatter plot for continuous data, age vs F7
## `geom_smooth()` using formula = 'y ~ x'
## 2024-06-26 19:52:19.283609 INFO::Creating scatter plot for continuous data, age vs F866
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:19.554015 INFO::Creating scatter plot for continuous data, age vs F593
## `geom_smooth()` using formula = 'y ~ x'
## 2024-06-26 19:52:19.819242 INFO::Creating scatter plot for continuous data, age vs F733
## `geom_smooth()` using formula = 'y ~ x'
## 2024-06-26 19:52:20.060763 INFO::Creating scatter plot for continuous data, age vs F684
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:20.325707 INFO::Creating scatter plot for continuous data, age vs F410
## `geom_smooth()` using formula = 'y ~ x'
## 2024-06-26 19:52:20.599871 INFO::Creating scatter plot for continuous data, age vs F224
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:20.919277 INFO::Creating scatter plot for continuous data, age vs F722
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:21.236962 INFO::Creating scatter plot for continuous data, age vs F856
## `geom_smooth()` using formula = 'y ~ x'
## 2024-06-26 19:52:21.517321 INFO::Creating scatter plot for continuous data, age vs F680
## `geom_smooth()` using formula = 'y ~ x'
## 2024-06-26 19:52:21.807525 INFO::Creating scatter plot for continuous data, age vs F19
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:22.122048 INFO::Creating scatter plot for continuous data, age vs F860
## `geom_smooth()` using formula = 'y ~ x'
## 2024-06-26 19:52:22.411757 INFO::Creating scatter plot for continuous data, age vs F859
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:22.73651 INFO::Creating scatter plot for continuous data, age vs F522
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:23.036299 INFO::Creating scatter plot for continuous data, age vs F372
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:23.257864 INFO::Creating scatter plot for continuous data, age vs F899
## `geom_smooth()` using formula = 'y ~ x'
## 2024-06-26 19:52:23.457617 INFO::Creating scatter plot for continuous data, age vs F782
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:23.777751 INFO::Creating scatter plot for continuous data, age vs F839
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:24.060266 INFO::Creating scatter plot for continuous data, age vs F827
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:24.346376 INFO::Creating scatter plot for continuous data, age vs F817
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:24.584069 INFO::Creating scatter plot for continuous data, age vs F345
## `geom_smooth()` using formula = 'y ~ x'
## 2024-06-26 19:52:24.791692 INFO::Creating scatter plot for continuous data, age vs F127
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:25.120555 INFO::Creating scatter plot for continuous data, age vs F749
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:25.426763 INFO::Creating scatter plot for continuous data, age vs F877
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:25.727913 INFO::Creating scatter plot for continuous data, age vs F150
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:25.961408 INFO::Creating scatter plot for continuous data, age vs F752
## `geom_smooth()` using formula = 'y ~ x'
## 2024-06-26 19:52:26.159975 INFO::Creating scatter plot for continuous data, age vs F848
## `geom_smooth()` using formula = 'y ~ x'
## 2024-06-26 19:52:26.407641 INFO::Creating scatter plot for continuous data, age vs F809
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:26.694442 INFO::Creating scatter plot for continuous data, age vs F751
## `geom_smooth()` using formula = 'y ~ x'
## 2024-06-26 19:52:26.88265 INFO::Creating scatter plot for continuous data, age vs F15
## `geom_smooth()` using formula = 'y ~ x'
## 2024-06-26 19:52:27.085962 INFO::Creating scatter plot for continuous data, age vs F521
## `geom_smooth()` using formula = 'y ~ x'
## 2024-06-26 19:52:27.311939 INFO::Creating scatter plot for continuous data, age vs F842
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:27.543532 INFO::Creating scatter plot for continuous data, age vs F319
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:27.859555 INFO::Creating scatter plot for continuous data, age vs F96
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:28.177084 INFO::Creating scatter plot for continuous data, age vs F171
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:28.396004 INFO::Creating scatter plot for continuous data, age vs F241
## `geom_smooth()` using formula = 'y ~ x'
## 2024-06-26 19:52:28.579503 INFO::Creating scatter plot for continuous data, age vs F582
## `geom_smooth()` using formula = 'y ~ x'
## 2024-06-26 19:52:28.750682 INFO::Creating scatter plot for continuous data, age vs F822
## `geom_smooth()` using formula = 'y ~ x'
## 2024-06-26 19:52:28.917278 INFO::Creating scatter plot for continuous data, age vs F748
## `geom_smooth()` using formula = 'y ~ x'
## 2024-06-26 19:52:29.099719 INFO::Creating scatter plot for continuous data, age vs F147
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:29.377685 INFO::Creating scatter plot for continuous data, age vs F16
## `geom_smooth()` using formula = 'y ~ x'
## 2024-06-26 19:52:29.673419 INFO::Creating scatter plot for continuous data, age vs F212
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:29.966606 INFO::Creating scatter plot for continuous data, age vs F718
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:30.200919 INFO::Creating scatter plot for continuous data, age vs F663
## `geom_smooth()` using formula = 'y ~ x'
## 2024-06-26 19:52:30.389734 INFO::Creating scatter plot for continuous data, age vs F690
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:30.616141 INFO::Creating scatter plot for continuous data, age vs F865
## `geom_smooth()` using formula = 'y ~ x'
## 2024-06-26 19:52:30.78848 INFO::Creating scatter plot for continuous data, age vs F421
## `geom_smooth()` using formula = 'y ~ x'
## 2024-06-26 19:52:30.971875 INFO::Creating scatter plot for continuous data, age vs F110
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:31.186047 INFO::Creating scatter plot for continuous data, age vs F857
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:31.449006 INFO::Creating scatter plot for continuous data, age vs F84
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:31.668285 INFO::Creating scatter plot for continuous data, age vs F123
## `geom_smooth()` using formula = 'y ~ x'
## 2024-06-26 19:52:31.876017 INFO::Creating scatter plot for continuous data, age vs F566
## `geom_smooth()` using formula = 'y ~ x'
## 2024-06-26 19:52:32.124431 INFO::Creating scatter plot for continuous data, age vs F370
## `geom_smooth()` using formula = 'y ~ x'
## 2024-06-26 19:52:32.396816 INFO::Creating scatter plot for continuous data, age vs F65
## `geom_smooth()` using formula = 'y ~ x'
## 2024-06-26 19:52:32.68794 INFO::Creating scatter plot for continuous data, age vs F119
## `geom_smooth()` using formula = 'y ~ x'
## 2024-06-26 19:52:32.981153 INFO::Creating scatter plot for continuous data, age vs F263
## `geom_smooth()` using formula = 'y ~ x'
## 2024-06-26 19:52:33.274858 INFO::Creating scatter plot for continuous data, age vs F630
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:33.595061 INFO::Creating scatter plot for continuous data, age vs F628
## `geom_smooth()` using formula = 'y ~ x'
## 2024-06-26 19:52:33.890491 INFO::Creating scatter plot for continuous data, age vs F711
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:34.293342 INFO::Creating scatter plot for continuous data, age vs F152
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:34.518113 INFO::Creating scatter plot for continuous data, age vs F324
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:34.836078 INFO::Creating scatter plot for continuous data, age vs F575
## `geom_smooth()` using formula = 'y ~ x'
## 2024-06-26 19:52:35.024694 INFO::Creating scatter plot for continuous data, age vs F699
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:35.247727 INFO::Creating scatter plot for continuous data, age vs F846
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:35.505089 INFO::Creating scatter plot for continuous data, age vs F380
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:35.796796 INFO::Creating scatter plot for continuous data, age vs F172
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:36.117775 INFO::Creating scatter plot for continuous data, age vs F504
## `geom_smooth()` using formula = 'y ~ x'
## 2024-06-26 19:52:36.403919 INFO::Creating scatter plot for continuous data, age vs F34
## `geom_smooth()` using formula = 'y ~ x'
## 2024-06-26 19:52:36.635472 INFO::Creating scatter plot for continuous data, age vs F199
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:36.921673 INFO::Creating scatter plot for continuous data, age vs F198
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:37.241473 INFO::Creating scatter plot for continuous data, age vs F479
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:37.511066 INFO::Creating scatter plot for continuous data, age vs F673
## `geom_smooth()` using formula = 'y ~ x'
## 2024-06-26 19:52:37.698653 INFO::Creating scatter plot for continuous data, age vs F508
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:37.93835 INFO::Creating scatter plot for continuous data, age vs F337
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:38.162507 INFO::Creating scatter plot for continuous data, age vs F737
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:38.475004 INFO::Creating scatter plot for continuous data, age vs F609
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:38.776542 INFO::Creating scatter plot for continuous data, age vs F40
## `geom_smooth()` using formula = 'y ~ x'
## 2024-06-26 19:52:38.977311 INFO::Creating scatter plot for continuous data, age vs F821
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:39.179895 INFO::Creating scatter plot for continuous data, age vs F643
## `geom_smooth()` using formula = 'y ~ x'
## 2024-06-26 19:52:39.377724 INFO::Creating scatter plot for continuous data, age vs F759
## `geom_smooth()` using formula = 'y ~ x'
## 2024-06-26 19:52:39.587774 INFO::Creating scatter plot for continuous data, age vs F417
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:39.779902 INFO::Creating scatter plot for continuous data, age vs F58
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:40.002253 INFO::Creating scatter plot for continuous data, age vs F267
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:40.204322 INFO::Creating scatter plot for continuous data, age vs F101
## `geom_smooth()` using formula = 'y ~ x'
## 2024-06-26 19:52:40.465512 INFO::Creating scatter plot for continuous data, age vs F890
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:40.719573 INFO::Creating scatter plot for continuous data, age vs F655
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:40.919125 INFO::Creating scatter plot for continuous data, age vs F95
## `geom_smooth()` using formula = 'y ~ x'
## 2024-06-26 19:52:41.226272 INFO::Creating scatter plot for continuous data, age vs F775
## `geom_smooth()` using formula = 'y ~ x'
## 2024-06-26 19:52:41.539455 INFO::Creating scatter plot for continuous data, age vs F93
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:41.830754 INFO::Creating scatter plot for continuous data, age vs F353
## `geom_smooth()` using formula = 'y ~ x'
## 2024-06-26 19:52:42.012282 INFO::Creating scatter plot for continuous data, age vs F480
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:42.307644 INFO::Creating scatter plot for continuous data, age vs F567
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:42.515461 INFO::Creating scatter plot for continuous data, age vs F871
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:42.703687 INFO::Creating scatter plot for continuous data, age vs F295
## `geom_smooth()` using formula = 'y ~ x'
## 2024-06-26 19:52:42.887776 INFO::Creating scatter plot for continuous data, age vs F459
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:43.099848 INFO::Creating scatter plot for continuous data, age vs F812
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:43.356829 INFO::Creating scatter plot for continuous data, age vs F146
## `geom_smooth()` using formula = 'y ~ x'
## 2024-06-26 19:52:43.621884 INFO::Creating scatter plot for continuous data, age vs F239
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:43.874083 INFO::Creating scatter plot for continuous data, age vs F754
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:44.105142 INFO::Creating scatter plot for continuous data, age vs F443
## `geom_smooth()` using formula = 'y ~ x'
## 2024-06-26 19:52:44.32237 INFO::Creating scatter plot for continuous data, age vs F5
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:44.589178 INFO::Creating scatter plot for continuous data, age vs F864
## `geom_smooth()` using formula = 'y ~ x'
## 2024-06-26 19:52:44.768631 INFO::Creating scatter plot for continuous data, age vs F477
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:44.964346 INFO::Creating scatter plot for continuous data, age vs F571
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-06-26 19:52:45.214516 INFO::Creating scatter plot for continuous data, age vs F715
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## `geom_smooth()` using formula = 'y ~ x'
## `geom_smooth()` using formula = 'y ~ x'
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## `geom_smooth()` using formula = 'y ~ x'
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## `geom_smooth()` using formula = 'y ~ x'
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## `geom_smooth()` using formula = 'y ~ x'
## `geom_smooth()` using formula = 'y ~ x'
## Initiating effect size calculations
##
## Calculating mean abundance in: IBD
##
## Calculating mean abundance in: Control
##
## Calculating effect size in: IBD
##
## Initiating prioritization
##
## Calculating meta-rank and prioritizing metabolic features
## 2024-06-26 19:52:48.601612 INFO::Writing all prioritized metabolites to file: Macarron_output/prioritized_metabolites_all.csv
## 2024-06-26 19:52:48.628614 INFO::Writing characterizable prioritized metabolites to file: Macarron_output/prioritized_metabolites_characterizable.csv
## 2024-06-26 19:52:48.671484 INFO::Writing highly prioritized metabolites in IBD to file: Macarron_output/highly_prioritized_per_module_in_IBD.csv
abundances_df = read.csv(file = prism_abundances, row.names = 1) # setting features as rownames
annotations_df = read.csv(file = prism_annotations, row.names = 1) # setting features as rownames
metadata_df = read.csv(file = prism_metadata, row.names = 1) # setting samples as rownames
taxonomy_df = read.csv(file = mets_taxonomy)
# Running Macarron
prism_prioritized <- Macarron::Macarron(input_abundances = abundances_df,
input_annotations = annotations_df,
input_metadata = metadata_df,
input_taxonomy = taxonomy_df)
The Macarron::Macarron()
function is a wrapper for the Macarron framework. Users can also apply individual functions on the input dataframes to achieve same results as the wrapper with the added benefit of storing output from each function for other analyses. There are seven steps:
# Step 1: Storing input data in a summarized experiment object
prism_mbx <- prepInput(input_abundances = abundances_df,
input_annotations = annotations_df,
input_metadata = metadata_df)
# Step 2: Creating a distance matrix from pairwise correlations in abundances of metabolic features
prism_w <- makeDisMat(se = prism_mbx)
# Step 3: Finding covariance modules
prism_modules <- findMacMod(se = prism_mbx,
w = prism_w,
input_taxonomy = taxonomy_df)
# The output is a list containing two dataframes- module assignments and measures of success
# if evaluateMOS=TRUE. To write modules to a separate dataframe, do:
prism_module_assignments <- prism_modules[[1]]
prism_modules_mos <- prism_modules[[2]]
# Step 4: Calculating AVA
prism_ava <- calAVA(se = prism_mbx,
mod.assn = prism_modules)
# Step 5: Calculating q-value
prism_qval <- calQval(se = prism_mbx,
mod.assn = prism_modules)
# Step 6: Calculating effect size
prism_es <- calES(se = prism_mbx,
mac.qval = prism_qval)
# Step 7: Prioritizing metabolic features
prism_prioritized <- prioritize(se = prism_mbx,
mod.assn = prism_modules,
mac.ava = prism_ava,
mac.qval = prism_qval,
mac.es = prism_es)
# The output is a list containing two dataframes- all prioritized metabolic features and
# only characterizable metabolic features.
all_prioritized <- prism_prioritized[[1]]
char_prioritized <- prism_prioritized[[2]]
# Step 8 (optional): View only the highly prioritized metabolic features in each module
prism_highly_prioritized <- showBest(prism_prioritized)
Session info from running the demo in R can be displayed with the following command.
sessionInfo()
## R version 4.4.0 (2024-04-24 ucrt)
## Platform: x86_64-w64-mingw32/x64
## Running under: Windows Server 2022 x64 (build 20348)
##
## Matrix products: default
##
##
## locale:
## [1] LC_COLLATE=C
## [2] LC_CTYPE=English_United States.utf8
## [3] LC_MONETARY=English_United States.utf8
## [4] LC_NUMERIC=C
## [5] LC_TIME=English_United States.utf8
##
## time zone: America/New_York
## tzcode source: internal
##
## attached base packages:
## [1] stats4 stats graphics grDevices utils datasets methods
## [8] base
##
## other attached packages:
## [1] Macarron_1.8.1 SummarizedExperiment_1.34.0
## [3] Biobase_2.64.0 GenomicRanges_1.56.1
## [5] GenomeInfoDb_1.40.1 IRanges_2.38.0
## [7] S4Vectors_0.42.0 BiocGenerics_0.50.0
## [9] MatrixGenerics_1.16.0 matrixStats_1.3.0
## [11] BiocStyle_2.32.1
##
## loaded via a namespace (and not attached):
## [1] mnormt_2.1.1 DBI_1.2.3 pbapply_1.7-2
## [4] gridExtra_2.3 rlang_1.1.4 magrittr_2.0.3
## [7] compiler_4.4.0 RSQLite_2.3.7 mgcv_1.9-1
## [10] png_0.1-8 vctrs_0.6.5 stringr_1.5.1
## [13] pkgconfig_2.0.3 crayon_1.5.3 fastmap_1.2.0
## [16] backports_1.5.0 XVector_0.44.0 labeling_0.4.3
## [19] utf8_1.2.4 rmarkdown_2.27 preprocessCore_1.66.0
## [22] UCSC.utils_1.0.0 bit_4.0.5 xfun_0.45
## [25] zlibbioc_1.50.0 cachem_1.1.0 jsonlite_1.8.8
## [28] blob_1.2.4 DelayedArray_0.30.1 BiocParallel_1.38.0
## [31] psych_2.4.3 Maaslin2_1.18.0 parallel_4.4.0
## [34] cluster_2.1.6 biglm_0.9-3 R6_2.5.1
## [37] RColorBrewer_1.1-3 stringi_1.8.4 bslib_0.7.0
## [40] rpart_4.1.23 jquerylib_0.1.4 Rcpp_1.0.12
## [43] bookdown_0.39 iterators_1.0.14 knitr_1.47
## [46] WGCNA_1.72-5 base64enc_0.1-3 Matrix_1.7-0
## [49] splines_4.4.0 nnet_7.3-19 tidyselect_1.2.1
## [52] rstudioapi_0.16.0 abind_1.4-5 yaml_2.3.8
## [55] doParallel_1.0.17 codetools_0.2-20 plyr_1.8.9
## [58] lattice_0.22-6 tibble_3.2.1 withr_3.0.0
## [61] KEGGREST_1.44.1 evaluate_0.24.0 foreign_0.8-87
## [64] survival_3.7-0 getopt_1.20.4 Biostrings_2.72.1
## [67] pillar_1.9.0 BiocManager_1.30.23 checkmate_2.3.1
## [70] foreach_1.5.2 pcaPP_2.0-4 generics_0.1.3
## [73] ggplot2_3.5.1 munsell_0.5.1 scales_1.3.0
## [76] glue_1.7.0 Hmisc_5.1-3 tools_4.4.0
## [79] robustbase_0.99-2 data.table_1.15.4 mvtnorm_1.2-5
## [82] fastcluster_1.2.6 grid_4.4.0 optparse_1.7.5
## [85] impute_1.78.0 AnnotationDbi_1.66.0 colorspace_2.1-0
## [88] nlme_3.1-165 GenomeInfoDbData_1.2.12 htmlTable_2.4.2
## [91] Formula_1.2-5 cli_3.6.3 fansi_1.0.6
## [94] S4Arrays_1.4.1 dplyr_1.1.4 DEoptimR_1.1-3
## [97] gtable_0.3.5 hash_2.2.6.3 logging_0.10-108
## [100] dynamicTreeCut_1.63-1 sass_0.4.9 digest_0.6.36
## [103] SparseArray_1.4.8 farver_2.1.2 htmlwidgets_1.6.4
## [106] memoise_2.0.1 htmltools_0.5.8.1 lifecycle_1.0.4
## [109] httr_1.4.7 GO.db_3.19.1 bit64_4.0.5
The input taxonomy dataframe can be generated using the input metabolic features annotation dataframe using Macarron::decorateID()
. This function annotates an HMDB ID or a PubChem CID with the chemical class and subclass of the metabolite.
taxonomy_df <- decorateID(input_annotations = annotations_df)
write.csv(taxonomy_df, file="demo_taxonomy.csv", row.names = FALSE)
A record of all chosen parameters and steps that were followed during execution.
This file provides information about the properties of covariance modules used in the analysis. By default, modules are generated using a minimum module size (MMS) (argument: min_module_size
) equal to cube root of the total number of prevalent metabolic features. Macarron evaluates 9 measures of success (MOS) that collectively capture the “correctness” and chemical homogeneity of the modules. The MOS are as follows:
This folder contains the Maaslin2 log file (maaslin2.log), significant associations found by Maaslin2 (significant_results.tsv) and the linear model residuals file (residuals.rds). For more information, see Maaslin2.
Ideally, at least 50% metabolic features must be retained after prevalence filtering. By default, Macarron uses the union of metabolic features observed (non-zero abundance) in at least 70% samples of any phenotype for further analysis. This prevalence threshold may be high for some metabolomics datasets and can be changed using the min_prevalence
argument.
prism_prioritized <- Macarron::Macarron(input_abundances = abundances_df,
input_annotations = annotations_df,
input_metadata = metadata_df,
input_taxonomy = taxonomy_df,
min_prevalence = 0.5)
# or
prism_w <- makeDisMat(se = prism_mbx,
min_prevalence = 0.5)
By default, cube root of the total number of prevalent features is used as the minimum module size (MMS) (argument: min_module_size
) for module detection and generation. We expect this to work for most real world datasets. To determine if the modules are optimal for further analysis, Macarron evaluates several measures of success (MOS) as described above. In addition to evaluating MOS for modules generated using the default MMS, Macarron also evaluates MOS for MMS values that are larger (MMS+5, MMS+10) and smaller (MMS-5, MMS-10) than the default MMS. If you find that the MOS improve with larger or smaller MMS, you may change the default accordingly. For more details about module detection, please see WGCNA
and dynamicTreeCut
.
# See MOS of modules generated using default
prism_modules <- findMacMod(se = prism_mbx,
w = prism_w,
input_taxonomy = taxonomy_df)
prism_modules_mos <- prism_modules[[2]]
View(prism_modules_mos)
# Change MMS
prism_modules <- findMacMod(se = prism_mbx,
w = prism_w,
input_taxonomy = taxonomy_df,
min_module_size = 10)
Macarron uses Maaslin2 for determining the q-value of differential abundance in a phenotype of interest. For default execution, the phenotype of interest must be a category in column 1 of the metadata dataframe e.g. IBD in diagnosis in the demo. This is also the column that is picked by the metadata_variable
argument for identifying the main phenotypes/conditions in any dataset (see Macarron.log file). Further, in the default execution, all columns in the metadata table are considered as fixed effects and the alphabetically first categorical variable in each covariate with two categories is considered as the reference. Maaslin2 requires reference categories to be explicitly defined for all categorical metadata with more than two categories.
Defaults can be changed with the arguments fixed_effects
, random_effects
and reference
. In the demo example, fixed effects
and reference
can be defined as follows:
prism_qval <- calQval(se = prism_mbx,
mod.assn = prism_modules,
metadata_variable = "diagnosis",
fixed_effects = c("diagnosis","age","antibiotics"),
reference = c("diagnosis,Control";"antibiotics,No"))
The package source contains a script MacarronCMD.R
in inst/scripts
to invoke Macarron in the command line using Rscript.
The inst/scripts
folder also contains a README file that comprehensively documents the usage of the script.